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Protein

Chromosomal replication initiator protein DnaA 1

Gene

dnaA1

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1548ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA 1
Gene namesi
Name:dnaA1
Ordered Locus Names:CT_250
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Chromosomal replication initiator protein DnaA 1PRO_0000114162Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT250.

Structurei

3D structure databases

ProteinModelPortaliO84252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
InParanoidiO84252.
KOiK02313.
OMAiKIEENSH.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAWEEFLLL QEKEIGVDTV NKWLRSLKVL CFDACNLYLE AKDSFQVTWF
60 70 80 90 100
EEHIRHKVKA SLINNNGKPI RVRVTSLDKS TPFKETQIQQ EKTAYFTMKY
110 120 130 140 150
GDIDPNMSFA NFLVTPENDL PVRILQEFAK VSEQGKGFPF NPIYLFGPES
160 170 180 190 200
SGKTHLMQAA VGGLREAGVK TLYVTSELFT EHLVSAIRSG EMQRFRAFYR
210 220 230 240 250
NVEALFIEDI EVLSGKGATQ EEFFHTFNSL HTEGKLIVIS STFAPGDLKA
260 270 280 290 300
MEERLISRFE WGISIPVSPL IREGLKSFLE RRTEKLNIRI EETALDFLIQ
310 320 330 340 350
ALSSHVKSLL HALTTLAKRV AYKKLSHQML YQGDIEALLH DVLQAAESIR
360 370 380 390 400
LTPSGIVRAT AQYYGVSPES VLGRSQSREY VLPRQVAMFL CRQKLSLSYV
410 420 430 440 450
KIGEVFSRDH STVISSIRAI SQKLEEDDRE CDVSRAIQEL TKRLSSAYQS

LDFIED
Length:456
Mass (Da):51,996
Last modified:November 1, 1998 - v1
Checksum:i50C7E6FD28B47DFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67843.1.
PIRiD71537.
RefSeqiNP_219755.1. NC_000117.1.
WP_009871597.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67843; AAC67843; CT_250.
GeneIDi884874.
KEGGictr:CT_250.
PATRICi20380017. VBIChlTra43535_0267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67843.1.
PIRiD71537.
RefSeqiNP_219755.1. NC_000117.1.
WP_009871597.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67843; AAC67843; CT_250.
GeneIDi884874.
KEGGictr:CT_250.
PATRICi20380017. VBIChlTra43535_0267.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
InParanoidiO84252.
KOiK02313.
OMAiKIEENSH.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA1_CHLTR
AccessioniPrimary (citable) accession number: O84252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.