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Reviewed, UniProtKB/Swiss-Prot O84242 (FABH_CHLTR)

Last modified November 3, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3
    EC=2.3.1.180
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase III
    Beta-ketoacyl-ACP synthase III
      Short name=KAS III
Gene names
Name: fabH
Ordered Locus Names: CT_239
OrganismChlamydia trachomatis [Complete proteome] [HAMAP]
Taxonomic identifier813 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

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Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity.

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH By similarity.

Sequence similarities

Belongs to the fabH family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3273273-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_0000110416

Regions

Region254 – 2585ACP-binding By similarity

Sites

Active site1121 By similarity
Active site2531 By similarity
Active site2831 By similarity

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Sequences

Sequence LengthMass (Da)Tools
O84242-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 6D92252184B44A38

FASTA32735,327
        10         20         30         40         50         60 
MRASIWGTGS YLPKKILTNA DLEKIVETSD EWISTRTGIK ERRIASAEEF SSFMGAKAAE 

        70         80         90        100        110        120 
KAIEAAKISK SQVDCIVFST AAPDYIFPSS AALAQAYLGI KEIPAFDCLA ACTGFLYGLS 

       130        140        150        160        170        180 
IAKAYVESGM YQCVLVIAAD KLSSFVNYQD RNTCVLFGDG GSACIVGHSR PGALEISKVN 

       190        200        210        220        230        240 
LGADGKQGDL LRLPAGGSRC PASQDTVQNH QHFITMEGKE VFKHAVRRME FAAKTCITEA 

       250        260        270        280        290        300 
GLQEKDIDWL VPHQANERII DAIAKRFAVK DSRVFKTLAK YGNTAASSVG IALDELLRTH 

       310        320 
DIHVAERLLL VAFGGGLSWG AVILQQV

« Hide

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References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed: 9784136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

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Cross-references

Sequence databases

AE001273 Genomic DNA. Translation: AAC67832.1.
PIRH71538.
RefSeqNP_219744.1.

3D structure databases

HSSPHSSP built from PDB template 1HNK based on UniProtKB P24249.
ModBaseSearch...

Genome annotation databases

GeneID884881.
GenomeReviewsGene locus CT_239 in contig AE001273_GR.
KEGGctr:CT239.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO84242.
OMAYSRITGT.

Enzyme and pathway databases

BioCycCTRA315277:CT239-MON.
BRENDA2.3.1.180. 108.

Family and domain databases

HAMAPMF_01815.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00747. fabH. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameFABH_CHLTR
AccessionPrimary (citable) accession number: O84242
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents