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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei603 – 6031ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CT_209
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligasePRO_0000152000Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT209.

Structurei

3D structure databases

ProteinModelPortaliO84211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi600 – 6045"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
InParanoidiO84211.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDPGLIEE KWQKFWENEQ VFKAEEDETK TKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HLIGYTATDI VARYKRAQGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT
110 120 130 140 150
EKNIANFKKQ LTAMGFSYDE SREFATSDPE YYKWTQKLFL ILYEKGLAYM
160 170 180 190 200
ADMAVNYCPE LGTVLSNEEI ENGFSVDGGY PVERRMLRQW VLRITAFADQ
210 220 230 240 250
LLEGLDELDW PESVKQLQKN WIGKSSGASV NFATEHGVIE VFTTRPDTLI
260 270 280 290 300
GVSFLALAPE HPLVDLLTSD EQKAVVAQYI KETQSKSERD RISEMKTKSG
310 320 330 340 350
VFTGSYAKHP VTHKLIPIWI ADYVLIGFGS GAVMGVPAHD ERDLLFAEQF
360 370 380 390 400
NLPVVSVLNK EGVCINSCCE GFHLDGLSGE EAKQYVINFL EENHLGAAKI
410 420 430 440 450
AYKLRDWLFS RQRYWGEPIP IIHFEDGSCR PLRDYELPLL PPEIQDYRPE
460 470 480 490 500
GVGQGPLAKV REWVQVFDTE TQRAGKRETH TMPQWAGSCW YYLRFCDAHN
510 520 530 540 550
SAAPWAKEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF YEAGIVSTPE
560 570 580 590 600
PFKKLVNQGL VLATSYRIPG KGYIYPEIAK EENGKWVAPS GEELDVRQEK
610 620 630 640 650
MSKSKLNGVD PQILIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF
660 670 680 690 700
LNRFYEMVSS DRVKEDNNFE GLSLAHKLVQ RVTDAIEKLS LNTIPSSFME
710 720 730 740 750
FINDFVKLAV YPKSAVEMAV RALAPIAPHI SEELWVLLGN SPGVQKSGWP
760 770 780 790 800
SVLPEYLEGQ TVTIVVQVNG KLRARLDIMK DASKEEVLAL ARESASKYLE
810
GCEVKKAIFV PARLVNFVV
Length:819
Mass (Da):92,903
Last modified:November 1, 1998 - v1
Checksum:i82412A659AFAFECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67801.1.
PIRiC71544.
RefSeqiNP_219713.1. NC_000117.1.
WP_010725124.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67801; AAC67801; CT_209.
GeneIDi884917.
KEGGictr:CT_209.
PATRICi20379927. VBIChlTra43535_0224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67801.1.
PIRiC71544.
RefSeqiNP_219713.1. NC_000117.1.
WP_010725124.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67801; AAC67801; CT_209.
GeneIDi884917.
KEGGictr:CT_209.
PATRICi20379927. VBIChlTra43535_0224.

Phylogenomic databases

eggNOGiCOG0495.
InParanoidiO84211.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiSYL_CHLTR
AccessioniPrimary (citable) accession number: O84211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.