O84192 (GYRA_CHLTR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 71.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA gyrase subunit A EC=5.99.1.3 | ||||
| Gene names |
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| Organism | Chlamydia trachomatis | ||||
| Taxonomic identifier | 813 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia |
Protein attributes
| Sequence length | 836 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. HAMAP MF_01897 |
| Catalytic activity | ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897 |
| Subunit structure | Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer. |
| Subcellular location | Cytoplasm Potential HAMAP MF_01897. |
| Sequence similarities | Belongs to the topoisomerase GyrA/ParC subunit family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Isomerase Topoisomerase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | DNA topological change Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependentInferred from electronic annotation. Source: InterPro |
| Cellular component | chromosome Inferred from electronic annotation. Source: InterPro cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 836 | 836 | DNA gyrase subunit A HAMAP MF_01897 | PRO_0000145230 | |||||
Sites | |||||||||
| Active site | 122 | 1 | O-(5'-phospho-DNA)-tyrosine intermediate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx. |
| [2] | "Sequencing of gyrase and topoisomerase IV QRDRs of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained in vitro." Dessus-Babus S., Bebear C.M., Charron A., Bebear C., de Barbeyrac B. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-179. Strain: L2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001273 Genomic DNA. Translation: AAC67781.1. AF044267 Genomic DNA. Translation: AAC33552.1. |
| PIR | F71546. |
| RefSeq | NP_219693.1. NC_000117.1. |
3D structure databases | |
| ProteinModelPortal | O84192. |
| ModBase | Search... |
2D gel databases | |
| PHCI-2DPAGE | O84192. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 884941. |
| GenomeReviews | Gene locus CT_189 in contig AE001273_GR. |
| KEGG | ctr:CT189. |
| PATRIC | 20379881. VBIChlTra43535_0203. |
Phylogenomic databases | |
| HOGENOM | HBG635183. |
| OMA | TGRGRIY. |
| ProtClustDB | PRK05560. |
Family and domain databases | |
| HAMAP | MF_01897. GyrA. [Tree] |
| InterPro | IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view] |
| Gene3D | G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit. |
| KO | K02469. |
| Pfam | PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view] |
| SMART | SM00434. TOP4c. 1 hit. [Graphical view] |
| SUPFAM | SSF56719. Topo_IIA_cen. 1 hit. |
| TIGRFAMs | TIGR01063. GyrA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GYRA_CHLTR | ||||||||
| Accession | Primary (citable) accession number: O84192 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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