O84191 (KTHY_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	CT_188

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Thymidylate kinase HAMAP MF_00165		PRO_0000155263
Regions
	Nucleotide binding	7 – 14	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O84191 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3DADCC3690112B7C	FASTA	203	22,473
	10 20 30 40 50 60 MFIVVEGGEG AGKTQFIQAL SKRLIEEGRE IVTTREPGGC SLGDSVRGLL LDPEQKISPY 70 80 90 100 110 120 AELLLFLAAR AQHIQEKIIP ALKSGKTVIS DRFHDSTIVY QGIAGGLGES FVTNLCYHVV 130 140 150 160 170 180 GDKPFLPDIT FLLDIPAREG LLRKARQKHL DKFEQKPQIF HRSVREGFLA LAEKAPDRYK 190 200 VLDALLPTEA SVDQALLQIR ALI

References

[1]	"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67780.1.
PIR	E71546.
RefSeq	NP_219692.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84191.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884942.
GenomeReviews	Gene locus CT_188 in contig AE001273_GR.
KEGG	ctr:CT188.
PATRIC	20379879. VBIChlTra43535_0202.
Phylogenomic databases
HOGENOM	HBG626009.
OMA	RFITFEG.
ProtClustDB	PRK00698.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_CHLTR

Accession

Primary (citable) accession number: O84191

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program