Reviewed, UniProtKB/Swiss-Prot O84188 (G6PD_CHLTR)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	CT_185

Organism

Chlamydia trachomatis [Complete proteome] [HAMAP]

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068117
Sites
	Active site	192	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	130	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O84188-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E091DE335A4D1189	FASTA	439	51,063
	10 20 30 40 50 60 MKLAVQHFSH SSEIDIRVWE SLENRIFYHQ ANFSDAEGYS VLKAYLEQLD QQYGTQGNRL 70 80 90 100 110 120 FYLSTPPDYF QEIIRNLNRH QLFYHEQGAQ QPWSRLIIEK PFGVNLETAR ELQQCIDANI 130 140 150 160 170 180 DEESVYRIDH YLGKETVQNI LTIRFANTLF ESCWNSQYID HVQISVSESI GIGSRGNFFE 190 200 210 220 230 240 KSGMLRDMVQ NHLTQLLCLL TMEPPSEFFS EEIKKEKIKI LKKILPIREE DAVRGQYGEG 250 260 270 280 290 300 IVQDVSVLGY REEENVDPNS SVETYVALKL FIDNPRWKGV PFYLQAGKRL PKRTTDIAVI 310 320 330 340 350 360 FKKSSYNLFN AENCPLCPLE NDLLIIRIQP DEGVALQFNC KVPGTNKLVR PVKMDFRYDS 370 380 390 400 410 420 YFNTVTPEAY ERLLCDCILG DRTLFTSNEE VLASWELFSP LLEKWSQVRP IFPNYMAGSL 430 RPQEADELLS RDGKAWRPY

References

[1]

"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001273 Genomic DNA. Translation: AAC67777.1.
PIR	B71546.
RefSeq	NP_219689.2.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
2-D gel databases
PHCI-2DPAGE	O84188.
Genome annotation databases
GeneID	884944.
GenomeReviews	Gene locus CT_185 in contig AE001273_GR.
KEGG	ctr:CT185.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O84188.
OMA	O84188. QRADNIE.
Enzyme and pathway databases
BioCyc	CTRA315277:CT185-MON.
BRENDA	1.1.1.49. 108.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_CHLTR

Accession

Primary (citable) accession number: O84188

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)