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O84188 (G6PD_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:CT_185
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068117

Sites

Active site1921Proton acceptor By similarity
Binding site1001NADP By similarity
Binding site1301Substrate By similarity
Binding site1341Substrate By similarity
Binding site1681Substrate By similarity
Binding site1871Substrate By similarity
Binding site2881Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O84188 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: E091DE335A4D1189

FASTA43951,063
        10         20         30         40         50         60 
MKLAVQHFSH SSEIDIRVWE SLENRIFYHQ ANFSDAEGYS VLKAYLEQLD QQYGTQGNRL 

        70         80         90        100        110        120 
FYLSTPPDYF QEIIRNLNRH QLFYHEQGAQ QPWSRLIIEK PFGVNLETAR ELQQCIDANI 

       130        140        150        160        170        180 
DEESVYRIDH YLGKETVQNI LTIRFANTLF ESCWNSQYID HVQISVSESI GIGSRGNFFE 

       190        200        210        220        230        240 
KSGMLRDMVQ NHLTQLLCLL TMEPPSEFFS EEIKKEKIKI LKKILPIREE DAVRGQYGEG 

       250        260        270        280        290        300 
IVQDVSVLGY REEENVDPNS SVETYVALKL FIDNPRWKGV PFYLQAGKRL PKRTTDIAVI 

       310        320        330        340        350        360 
FKKSSYNLFN AENCPLCPLE NDLLIIRIQP DEGVALQFNC KVPGTNKLVR PVKMDFRYDS 

       370        380        390        400        410        420 
YFNTVTPEAY ERLLCDCILG DRTLFTSNEE VLASWELFSP LLEKWSQVRP IFPNYMAGSL 

       430 
RPQEADELLS RDGKAWRPY 

« Hide

References

[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC67777.1.
PIRB71546.
RefSeqNP_219689.3. NC_000117.1.

3D structure databases

ProteinModelPortalO84188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC67777; AAC67777; CT_185.
GeneID884944.
PATRIC20379873. VBIChlTra43535_0199.

Phylogenomic databases

eggNOGCOG0364.
OMAAVVFKRA.
OrthoDBEOG61308Z.
ProtClustDBPRK05722.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_CHLTR
AccessionPrimary (citable) accession number: O84188
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways