O84172 (TRPB_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan synthase beta chain
EC=4.2.1.20

Gene names

Name:	trpB
Ordered Locus Names:	CT_170

Organism

Chlamydia trachomatis

Taxonomic identifier

813 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. HAMAP MF_00133
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP MF_00133
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00133
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP MF_00133
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Sequence similarities	Belongs to the TrpB family.
Caution	This TrpB is highly divergent compared to other bacterial TrpB. As C.trachomatis seems to have lost part of the Trp biosynthetic operon, it is possible that this protein is not active.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro tryptophan synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Tryptophan synthase beta chain HAMAP MF_00133		PRO_0000098941
Amino acid modifications
	Modified residue	84	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O84172 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3340FECFFF9880BF	FASTA	392	42,618
	10 20 30 40 50 60 MFKHKHPFGG AFLPEELLAP IQNLKAEWEI LKTQQSFLSE LDCILKNYAG RQTPLTEVKN 70 80 90 100 110 120 FARAIDGPRV FLKREDLLHT GAHKLNNALG QCLLAKYLGK TRVVAETGAG QHGVATATAC 130 140 150 160 170 180 AYLGLDCVVY MGAKDVERQK PNVEKMRFLG AEVVSVTKGS CGLKDAVNQA LQDWATTHSF 190 200 210 220 230 240 THYCLGSALG PLPYPDIVRF FQSVISAEVK EQIHAVAGRD PDILIACIGG GSNAIGFFHH 250 260 270 280 290 300 FIPNPKVQLI GVEGGGLGIS SGKHAARFAT GRPGVFHGFY SYLLQDDDGQ VLQTHSISAG 310 320 330 340 350 360 LDYPSVGPDH AEMHESGRAF YTLATDEEAL RAFFLLTRNE GIIPALESSH ALAHLVSIAP 370 380 390 SLPKEQIVIV NLSGRGDKDL PQIIRRNRGI YE

References

[1]	"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis." Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W. Science 282:754-759(1998) [PubMed: 9784136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D/UW-3/Cx.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001273 Genomic DNA. Translation: AAC67761.1.
PIR	A71547.
RefSeq	NP_219673.1. NC_000117.1.
3D structure databases
ProteinModelPortal	O84172.
SMR	O84172. Positions 7-385.
ModBase	Search...
2D gel databases
PHCI-2DPAGE	O84172.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	884961.
GenomeReviews	Gene locus CT_170 in contig AE001273_GR.
KEGG	ctr:CT170.
PATRIC	20379837. VBIChlTra43535_0183.
Phylogenomic databases
HOGENOM	HBG303148.
OMA	AGSINTK.
ProtClustDB	PRK04346.
Family and domain databases
HAMAP	MF_00133. Trp_synth_beta. Divergent sequence. [Tree]
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR006653. Trp_synth_b_CS. IPR006654. Trp_synth_beta. IPR023026. Trp_synth_beta/beta-like. [Graphical view]
KO	K01696.
PANTHER	PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00263. TrpB. 1 hit.
PROSITE	PS00168. TRP_SYNTHASE_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPB_CHLTR

Accession

Primary (citable) accession number: O84172

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program