Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O84147

- PKN1_CHLTR

UniProt

O84147 - PKN1_CHLTR

Protein

Serine/threonine-protein kinase pkn1

Gene

pkn1

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth. Phosphorylates IncG, a inclusion-membrane protein required for the modification of the nascent chlamydial inclusion.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase pkn1 (EC:2.7.11.1)
    Gene namesi
    Name:pkn1
    Ordered Locus Names:CT_145
    OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
    Taxonomic identifieri272561 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000431: Chromosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi42 – 421K → A: Loss of activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Serine/threonine-protein kinase pkn1PRO_0000171189Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues.1 Publication

    Keywords - PTMi

    Phosphoprotein

    PTM databases

    PhosSiteiP0501121.

    Expressioni

    Developmental stagei

    Expressed at early mid-phase of the developmental cycle.

    Interactioni

    Protein-protein interaction databases

    STRINGi272561.CT145.

    Structurei

    3D structure databases

    ProteinModelPortaliO84147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 276264Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OMAiFIRYLEC.
    OrthoDBiEOG622PMB.

    Family and domain databases

    Gene3Di3.90.1580.10. 1 hit.
    InterProiIPR016187. C-type_lectin_fold.
    IPR005532. FGE_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF03781. FGE-sulfatase. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O84147-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEERAAVEYW GDYKVIAELG HGLWSRDVLA EHRFIKKRYI LKILPSELSS    50
    SENFMRVFQE VIVQLAAIRH ASLVAIENVS REGDRYFVVT EENGGTISLA 100
    QYLSGRKLSE EEVVHLIQQL CDALELVHSI GLAHGQIHLH SVHVSFFNGI 150
    ANIYLPEVGF ASLLRERMFS TIMQSGSARE SITRIRDLLM FEAPEEQEVF 200
    GREADVYSVG VLAYYLLVGS FPWGSFPKPS LCMPDSWYDW DGFILSCLQQ 250
    QREVRPKCLR EALRRKTSGE QLQVTLDSCR EPLREMEIED TPTELGPPSA 300
    LIREGERLCE VKEEQHAFVL VEAKSIDEVM VTTVDSEEEL ESSEGYANPL 350
    QSLLAREPVV SRYVEVEREE IKPQPLLTEM IFIEGGEFSR GSGDGQRDEL 400
    PVHNITLPGF FLDIHPVTNE QFVRFLECVG SEQDEHYNEL IRLKDSRIQR 450
    RSGRLIIEPG YAKHPVVGVT WYGASSYACW IGKRLPSEAE WEVAASGGKL 500
    GLRYPTGEEI DKSKANFFSS DTTPVMSYPS SILGLYDMAG NVYEWCQDWY 550
    SYDFYESSAL EPDAPLGPPQ GVYRVLRGGC WKSLKDDLRC AHRHRNNPGA 600
    INSTYGFRCA KDVK 614
    Length:614
    Mass (Da):69,694
    Last modified:November 1, 1998 - v1
    Checksum:i28BEC559CD694001
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21E → D in AAN71625. (PubMed:14500499)Curated
    Sequence conflicti14 – 141K → R in AAN71625. (PubMed:14500499)Curated
    Sequence conflicti32 – 321H → R in AAN71625. (PubMed:14500499)Curated
    Sequence conflicti105 – 1051G → R in AAN71625. (PubMed:14500499)Curated
    Sequence conflicti254 – 2541V → A in AAN71625. (PubMed:14500499)Curated
    Sequence conflicti329 – 3291V → A in AAN71625. (PubMed:14500499)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC67736.1.
    AY148435 Genomic DNA. Translation: AAN71625.1.
    PIRiB71551.
    RefSeqiNP_219648.1. NC_000117.1.

    Genome annotation databases

    EnsemblBacteriaiAAC67736; AAC67736; CT_145.
    GeneIDi884193.
    KEGGictr:CT_145.
    PATRICi20379787. VBIChlTra43535_0158.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001273 Genomic DNA. Translation: AAC67736.1 .
    AY148435 Genomic DNA. Translation: AAN71625.1 .
    PIRi B71551.
    RefSeqi NP_219648.1. NC_000117.1.

    3D structure databases

    ProteinModelPortali O84147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272561.CT145.

    PTM databases

    PhosSitei P0501121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC67736 ; AAC67736 ; CT_145 .
    GeneIDi 884193.
    KEGGi ctr:CT_145.
    PATRICi 20379787. VBIChlTra43535_0158.

    Phylogenomic databases

    eggNOGi COG0515.
    OMAi FIRYLEC.
    OrthoDBi EOG622PMB.

    Family and domain databases

    Gene3Di 3.90.1580.10. 1 hit.
    InterProi IPR016187. C-type_lectin_fold.
    IPR005532. FGE_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF03781. FGE-sulfatase. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
      Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
      Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D/UW-3/Cx.
    2. "Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1."
      Verma A., Maurelli A.T.
      Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKND, PHOSPHORYLATION OF INCG, MUTAGENESIS OF LYS-42.
      Strain: L2.

    Entry informationi

    Entry nameiPKN1_CHLTR
    AccessioniPrimary (citable) accession number: O84147
    Secondary accession number(s): Q8GDH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Gln-136 is present instead of the conserved Asp which is expected to be an active site residue.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3