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O84147

- PKN1_CHLTR

UniProt

O84147 - PKN1_CHLTR

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Protein
Serine/threonine-protein kinase pkn1
Gene
pkn1, CT_145
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth. Phosphorylates IncG, a inclusion-membrane protein required for the modification of the nascent chlamydial inclusion.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pkn1 (EC:2.7.11.1)
Gene namesi
Name:pkn1
Ordered Locus Names:CT_145
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000431: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi42 – 421K → A: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Serine/threonine-protein kinase pkn1
PRO_0000171189Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

PhosSiteiP0501121.

Expressioni

Developmental stagei

Expressed at early mid-phase of the developmental cycle.

Interactioni

Protein-protein interaction databases

STRINGi272561.CT145.

Structurei

3D structure databases

ProteinModelPortaliO84147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 276264Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
OMAiFIRYLEC.
OrthoDBiEOG622PMB.

Family and domain databases

Gene3Di3.90.1580.10. 1 hit.
InterProiIPR016187. C-type_lectin_fold.
IPR005532. FGE_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF03781. FGE-sulfatase. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84147-1 [UniParc]FASTAAdd to Basket

« Hide

MEERAAVEYW GDYKVIAELG HGLWSRDVLA EHRFIKKRYI LKILPSELSS    50
SENFMRVFQE VIVQLAAIRH ASLVAIENVS REGDRYFVVT EENGGTISLA 100
QYLSGRKLSE EEVVHLIQQL CDALELVHSI GLAHGQIHLH SVHVSFFNGI 150
ANIYLPEVGF ASLLRERMFS TIMQSGSARE SITRIRDLLM FEAPEEQEVF 200
GREADVYSVG VLAYYLLVGS FPWGSFPKPS LCMPDSWYDW DGFILSCLQQ 250
QREVRPKCLR EALRRKTSGE QLQVTLDSCR EPLREMEIED TPTELGPPSA 300
LIREGERLCE VKEEQHAFVL VEAKSIDEVM VTTVDSEEEL ESSEGYANPL 350
QSLLAREPVV SRYVEVEREE IKPQPLLTEM IFIEGGEFSR GSGDGQRDEL 400
PVHNITLPGF FLDIHPVTNE QFVRFLECVG SEQDEHYNEL IRLKDSRIQR 450
RSGRLIIEPG YAKHPVVGVT WYGASSYACW IGKRLPSEAE WEVAASGGKL 500
GLRYPTGEEI DKSKANFFSS DTTPVMSYPS SILGLYDMAG NVYEWCQDWY 550
SYDFYESSAL EPDAPLGPPQ GVYRVLRGGC WKSLKDDLRC AHRHRNNPGA 600
INSTYGFRCA KDVK 614
Length:614
Mass (Da):69,694
Last modified:November 1, 1998 - v1
Checksum:i28BEC559CD694001
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21E → D in AAN71625. 1 Publication
Sequence conflicti14 – 141K → R in AAN71625. 1 Publication
Sequence conflicti32 – 321H → R in AAN71625. 1 Publication
Sequence conflicti105 – 1051G → R in AAN71625. 1 Publication
Sequence conflicti254 – 2541V → A in AAN71625. 1 Publication
Sequence conflicti329 – 3291V → A in AAN71625. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC67736.1.
AY148435 Genomic DNA. Translation: AAN71625.1.
PIRiB71551.
RefSeqiNP_219648.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67736; AAC67736; CT_145.
GeneIDi884193.
KEGGictr:CT_145.
PATRICi20379787. VBIChlTra43535_0158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001273 Genomic DNA. Translation: AAC67736.1 .
AY148435 Genomic DNA. Translation: AAN71625.1 .
PIRi B71551.
RefSeqi NP_219648.1. NC_000117.1.

3D structure databases

ProteinModelPortali O84147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272561.CT145.

PTM databases

PhosSitei P0501121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC67736 ; AAC67736 ; CT_145 .
GeneIDi 884193.
KEGGi ctr:CT_145.
PATRICi 20379787. VBIChlTra43535_0158.

Phylogenomic databases

eggNOGi COG0515.
OMAi FIRYLEC.
OrthoDBi EOG622PMB.

Family and domain databases

Gene3Di 3.90.1580.10. 1 hit.
InterProi IPR016187. C-type_lectin_fold.
IPR005532. FGE_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF03781. FGE-sulfatase. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.
  2. "Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1."
    Verma A., Maurelli A.T.
    Infect. Immun. 71:5772-5784(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, INTERACTION WITH PKND, PHOSPHORYLATION OF INCG, MUTAGENESIS OF LYS-42.
    Strain: L2.

Entry informationi

Entry nameiPKN1_CHLTR
AccessioniPrimary (citable) accession number: O84147
Secondary accession number(s): Q8GDH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Gln-136 is present instead of the conserved Asp which is expected to be an active site residue.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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