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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Gene

accB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Biotin

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase
Short name:
BCCP
Gene namesi
Name:accB
Ordered Locus Names:CT_123
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Biotin carboxyl carrier protein of acetyl-CoA carboxylasePRO_0000146804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281N6-biotinyllysinePROSITE-ProRule annotationBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272561.CT123.

Structurei

3D structure databases

ProteinModelPortaliO84125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 16277Biotinyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105KM4. Bacteria.
COG0511. LUCA.
InParanoidiO84125.
KOiK02160.
OMAiEVEYPCK.
OrthoDBiEOG6CVV6Z.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKQIEKLM IAMGRNKMKR IVIKREGLEL ELERDTVPSI QEPVFYDNRL
60 70 80 90 100
FAGFSQERPI PTDQNLGNPI VKESIEKKES EAPAQGDFIV SPLVGTFYGS
110 120 130 140 150
PSPEAPAFIK PGDTVSEDTV VCIVEAMKVM NEVKAGMSGR VEEILITNGD
160
PVQFGSKLFR IVKA
Length:164
Mass (Da):18,198
Last modified:November 1, 1998 - v1
Checksum:iBD0BA4CEBC2D384C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67714.1.
PIRiG71553.
RefSeqiNP_219626.1. NC_000117.1.
WP_009871470.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67714; AAC67714; CT_123.
GeneIDi884172.
KEGGictr:CT_123.
PATRICi20379737. VBIChlTra43535_0135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67714.1.
PIRiG71553.
RefSeqiNP_219626.1. NC_000117.1.
WP_009871470.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67714; AAC67714; CT_123.
GeneIDi884172.
KEGGictr:CT_123.
PATRICi20379737. VBIChlTra43535_0135.

Phylogenomic databases

eggNOGiENOG4105KM4. Bacteria.
COG0511. LUCA.
InParanoidiO84125.
KOiK02160.
OMAiEVEYPCK.
OrthoDBiEOG6CVV6Z.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.

Entry informationi

Entry nameiBCCP_CHLTR
AccessioniPrimary (citable) accession number: O84125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.