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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi406 – 4138GTPBy similarity
Nucleotide bindingi452 – 4565GTPBy similarity
Nucleotide bindingi506 – 5094GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:CT_096
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Translation initiation factor IF-2PRO_0000137191Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT096.

Structurei

3D structure databases

ProteinModelPortaliO84098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini397 – 566170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni406 – 4138G1By similarity
Regioni431 – 4355G2By similarity
Regioni452 – 4554G3By similarity
Regioni506 – 5094G4By similarity
Regioni542 – 5443G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
InParanoidiO84098.
KOiK02519.
OMAiDNRTGGY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVKLTKNL KLKIKNAQLT KAAGLDKLKQ KLAQAGSSDT KNSPASKAQT
60 70 80 90 100
KEKSSKKTAG TPAPAPEVDS GATESTARRI RAKDRSSFAA EPTVTTALPG
110 120 130 140 150
DASHLTLDAI PAMKAPEITS VTQKEQTLGE CTDTSSVQQE EKKESSEETS
160 170 180 190 200
PERVEETLII RTRTEPKSVV SIKPKFGPTG KHINHLLAKT FKAPAKETKA
210 220 230 240 250
ASTEETTQQQ PRQNDAASYN NKQQPSGTSS RPASSAPSYR RESTNNNNNA
260 270 280 290 300
KRGSERDRSK RSDESVKAFT GRDRYGLNEG SSEEDKWRKK RVHKTKKQAE
310 320 330 340 350
EHVVQCPAHI KIALPITVKD LAAEMKLKAS ELIQKLFIHG MTYVVNDVLD
360 370 380 390 400
SQTVVEYIGL EFGCTIEIDS SAKEKLCLLE NAVRDEVNAT DPEKLIIRSP
410 420 430 440 450
IVAFMGHVDH GKTTIIDALR QSNMAASEAG AITQHTGAFK CTTPVGEITV
460 470 480 490 500
LDTPGHEAFS AMRARGAEVC DIVVLVVAGD EGIKEQTIEA IEHAKGANIT
510 520 530 540 550
IVVAINKCDK PNFNVETVYR QLAELDLLPE AWGGSIATIN TSAKTGEGLQ
560 570 580 590 600
DLLEMLALQA EVLELKADPS ARARGLVIES ELHKGLGAVA TVLVQNGTLH
610 620 630 640 650
LGEALVFNDC YGKVKTMHDE HNQLLQSATP STPVLITGLS AIPKAGDPFI
660 670 680 690 700
VVKNEKVAKE IISARLAGQQ RSAALQKKRP NFDAVLQNKK TLKLIIKADV
710 720 730 740 750
QGSIEALAHS ILNIRSEKVD VEILSSEVGD ISESDIRLAS ASKATVIGFH
760 770 780 790 800
TSVESHAEPL IKNLNVKVCL FDIIYHAVDA IKEIMTGLLD PIAEEKNLGA
810 820 830 840 850
AEIKATFKSS QLGTIYGCLV TEGTIVRNQK IRIIRDKEVL WKGSLSSLKR
860 870 880 890
LKEDVKEVKK GMECGILLDN YQQAQVGDIL QCYEVIYHPQ KL
Length:892
Mass (Da):97,010
Last modified:November 1, 1998 - v1
Checksum:i9D401C079D6B1A51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67687.1.
PIRiH71558.
RefSeqiNP_219599.1. NC_000117.1.
WP_009871444.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67687; AAC67687; CT_096.
GeneIDi884165.
KEGGictr:CT_096.
PATRICi20379677. VBIChlTra43535_0105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67687.1.
PIRiH71558.
RefSeqiNP_219599.1. NC_000117.1.
WP_009871444.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67687; AAC67687; CT_096.
GeneIDi884165.
KEGGictr:CT_096.
PATRICi20379677. VBIChlTra43535_0105.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
InParanoidiO84098.
KOiK02519.
OMAiDNRTGGY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_CHLTR
AccessioniPrimary (citable) accession number: O84098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.