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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31TyrosineUniRule annotation1
Binding sitei162TyrosineUniRule annotation1
Binding sitei166TyrosineUniRule annotation1
Binding sitei225ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-67-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:CT_062
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556511 – 412Tyrosine--tRNA ligaseAdd BLAST412

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO84065
SMRiO84065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini345 – 411S4 RNA-bindingUniRule annotationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 45"HIGH" region10
Motifi222 – 226"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DA0 Bacteria
COG0162 LUCA
InParanoidiO84065
KOiK01866
OMAiVNYMMAK

Family and domain databases

CDDicd00165 S4, 1 hit
cd00805 TyrRS_core, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02006 Tyr_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
IPR024107 Tyr-tRNA-ligase_bac_1
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF01479 S4, 1 hit
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
SMARTiView protein in SMART
SM00363 S4, 1 hit
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

O84065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQLIDNLKK RGILDNSSAG LESLTVPVSA YLGFDPTAPS LHIGHWIGIC
60 70 80 90 100
FLRRLAAYGI TPVALVGGAT GMIGDPSGKS VERSLLDQAQ VLDNSKKIAA
110 120 130 140 150
ALASYLPGIR IVNNADWLGS LSMVDFLRDV GKHFRLGSML AKDVVKQRVY
160 170 180 190 200
SEEGISYTEF SYLLLQSYDF AHLFKEHNVV LQCGGSDQWG NITSGIDYIR
210 220 230 240 250
RRGLGQAYGL TYPLLTDSKG KKIGKTESGT IWLDPALTPP YELFQYFLRL
260 270 280 290 300
PDQEISKVMR TLTLLDNEEI FALDERLTSD PQAVKKYIAE VIVKDVHGSE
310 320 330 340 350
GLAQAQAATE SFFASKGKSI TEAELVALVE SGVGVKVARA DLIGKRWLDI
360 370 380 390 400
VVELGFCSSR GQARRLIQQR GLYINQEPLA DEQSILDGTQ LCFDRYVLLS
410
QGKRKKQVID LN
Length:412
Mass (Da):45,435
Last modified:November 1, 1998 - v1
Checksum:i07EEF538F0C5A2C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67653.1
PIRiH71560
RefSeqiNP_219565.1, NC_000117.1
WP_009873530.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67653; AAC67653; CT_062
GeneIDi35550585
884058
KEGGictr:CT_062
PATRICifig|272561.5.peg.71

Similar proteinsi

Entry informationi

Entry nameiSYY_CHLTR
AccessioniPrimary (citable) accession number: O84065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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