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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).By similarity

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi263 – 2631Manganese 2By similarity
Metal bindingi268 – 2681Manganese 1By similarity
Metal bindingi268 – 2681Manganese 2By similarity
Active sitei275 – 2751Sequence analysis
Metal bindingi286 – 2861Manganese 2By similarity
Metal bindingi345 – 3451Manganese 1By similarity
Metal bindingi347 – 3471Manganese 1By similarity
Metal bindingi347 – 3471Manganese 2By similarity
Active sitei349 – 3491Sequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:CT_045
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Probable cytosol aminopeptidasePRO_0000165741Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272561.CT045.

Structurei

3D structure databases

ProteinModelPortaliO84049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

eggNOGiENOG4105BZ6. Bacteria.
COG0260. LUCA.
InParanoidiO84049.
KOiK01255.
OMAiGIVGMKS.

Family and domain databases

CDDicd00433. Peptidase_M17. 1 hit.
HAMAPiMF_00181. Cytosol_peptidase_M17. 1 hit.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERiPTHR11963. PTHR11963. 1 hit.
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O84049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLYSQASW DKRSKADALV LPFWMKNSKA QEAAVVDEDY KLVYQNALSN
60 70 80 90 100
FSGKKGETAF LFGNDHTKEQ KIVLLGLGKS EEVSGTTVLE AYAQATTVLR
110 120 130 140 150
KAKCKTVNIL LPTISQLRFS VEEFLTNLAA GVLSLNYNYP TYHKVDTSLP
160 170 180 190 200
FLEKVTVMGI VSKVGDKIFR KEESLFEGVY LTRDLVNTNA DEVTPEKLAA
210 220 230 240 250
VAKDLAGEFA SLDVKILDRK AILKEKMGLL AAVAKGAAVE PRFIVLDYQG
260 270 280 290 300
KPKSKDRTVL IGKGVTFDSG GLDLKPGKAM ITMKEDMAGA ATVLGIFSAL
310 320 330 340 350
ASLELPINVT GIIPATENAI GSAAYKMGDV YVGMTGLSVE IGSTDAEGRL
360 370 380 390 400
ILADAISYAL KYCNPTRIID FATLTGAMVV SLGESVAGFF ANNDVLARDL
410 420 430 440 450
AEASSETGEA LWRMPLVEKY DQALHSDIAD MKNIGSNRAG SITAALFLQR
460 470 480 490
FLEDNPVAWA HLDIAGTAYH EKEELPYPKY ATGFGVRCLI HYMEKFLSK
Length:499
Mass (Da):54,210
Last modified:November 1, 1998 - v1
Checksum:i04F517A9E7FB8254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67636.1.
PIRiC71563.
RefSeqiNP_219548.1. NC_000117.1.
WP_009871393.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67636; AAC67636; CT_045.
GeneIDi884033.
KEGGictr:CT_045.
PATRICi20379567. VBIChlTra43535_0051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA. Translation: AAC67636.1.
PIRiC71563.
RefSeqiNP_219548.1. NC_000117.1.
WP_009871393.1. NC_000117.1.

3D structure databases

ProteinModelPortaliO84049.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT045.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67636; AAC67636; CT_045.
GeneIDi884033.
KEGGictr:CT_045.
PATRICi20379567. VBIChlTra43535_0051.

Phylogenomic databases

eggNOGiENOG4105BZ6. Bacteria.
COG0260. LUCA.
InParanoidiO84049.
KOiK01255.
OMAiGIVGMKS.

Family and domain databases

CDDicd00433. Peptidase_M17. 1 hit.
HAMAPiMF_00181. Cytosol_peptidase_M17. 1 hit.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERiPTHR11963. PTHR11963. 1 hit.
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMPA_CHLTR
AccessioniPrimary (citable) accession number: O84049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.