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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).By similarity

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi263Manganese 2By similarity1
Metal bindingi268Manganese 1By similarity1
Metal bindingi268Manganese 2By similarity1
Active sitei275Sequence analysis1
Metal bindingi286Manganese 2By similarity1
Metal bindingi345Manganese 1By similarity1
Metal bindingi347Manganese 1By similarity1
Metal bindingi347Manganese 2By similarity1
Active sitei349Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-49-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:CT_045
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001657411 – 499Probable cytosol aminopeptidaseAdd BLAST499

Structurei

3D structure databases

ProteinModelPortaliO84049
SMRiO84049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

eggNOGiENOG4105BZ6 Bacteria
COG0260 LUCA
InParanoidiO84049
KOiK01255
OMAiMKNTGPR

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
IPR008283 Peptidase_M17_N
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PF02789 Peptidase_M17_N, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

Sequencei

Sequence statusi: Complete.

O84049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLYSQASW DKRSKADALV LPFWMKNSKA QEAAVVDEDY KLVYQNALSN
60 70 80 90 100
FSGKKGETAF LFGNDHTKEQ KIVLLGLGKS EEVSGTTVLE AYAQATTVLR
110 120 130 140 150
KAKCKTVNIL LPTISQLRFS VEEFLTNLAA GVLSLNYNYP TYHKVDTSLP
160 170 180 190 200
FLEKVTVMGI VSKVGDKIFR KEESLFEGVY LTRDLVNTNA DEVTPEKLAA
210 220 230 240 250
VAKDLAGEFA SLDVKILDRK AILKEKMGLL AAVAKGAAVE PRFIVLDYQG
260 270 280 290 300
KPKSKDRTVL IGKGVTFDSG GLDLKPGKAM ITMKEDMAGA ATVLGIFSAL
310 320 330 340 350
ASLELPINVT GIIPATENAI GSAAYKMGDV YVGMTGLSVE IGSTDAEGRL
360 370 380 390 400
ILADAISYAL KYCNPTRIID FATLTGAMVV SLGESVAGFF ANNDVLARDL
410 420 430 440 450
AEASSETGEA LWRMPLVEKY DQALHSDIAD MKNIGSNRAG SITAALFLQR
460 470 480 490
FLEDNPVAWA HLDIAGTAYH EKEELPYPKY ATGFGVRCLI HYMEKFLSK
Length:499
Mass (Da):54,210
Last modified:November 1, 1998 - v1
Checksum:i04F517A9E7FB8254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67636.1
PIRiC71563
RefSeqiNP_219548.1, NC_000117.1
WP_009871393.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67636; AAC67636; CT_045
GeneIDi35556167
884033
KEGGictr:CT_045
PATRICifig|272561.5.peg.51

Similar proteinsi

Entry informationi

Entry nameiAMPA_CHLTR
AccessioniPrimary (citable) accession number: O84049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health