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Protein

ATP-dependent Clp protease proteolytic subunit 2

Gene

clpP2

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophileUniRule annotation
Active sitei123 – 1231UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-1096-MONOMER.
BRENDAi3.4.21.92. 6429.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 2UniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 2UniRule annotation
Gene namesi
Name:clpP2UniRule annotation
Synonyms:clpP-2
Ordered Locus Names:TP_1041
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199ATP-dependent Clp protease proteolytic subunit 2PRO_0000179705Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP1041.

Structurei

3D structure databases

ProteinModelPortaliO84003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108S10. Bacteria.
COG0740. LUCA.
KOiK01358.
OMAiNMIRFVK.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

O84003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCDATQEKR AHSESGESVF FQKFLETRQI LLSGEISKDL AEGIVRQLFV
60 70 80 90 100
LESLSVSKPI YMYVDSPGGD VDAGYAIFDV IRFVKTPVYT IGMGLVASAG
110 120 130 140 150
VLVLLAAKKD CRFGLRNSRY LIHQPLSGMR GVATDIEIHA RELEKTRSKL
160 170 180 190
NALIASETGV SLDKVAQDTN RDYWLDASQA LEYGLISNLI EKRADLPKK
Length:199
Mass (Da):22,086
Last modified:September 26, 2001 - v2
Checksum:iCC5025ACD9AB63AE
GO

Sequence cautioni

The sequence AAC26595.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC26595.1. Different initiation.
PIRiH71250.
RefSeqiWP_014342706.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC26595; AAC26595; TP_1041.
GeneIDi2611349.
KEGGitpa:TP_1041.
PATRICi20532213. VBITrePal57110_1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC26595.1. Different initiation.
PIRiH71250.
RefSeqiWP_014342706.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO84003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP1041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC26595; AAC26595; TP_1041.
GeneIDi2611349.
KEGGitpa:TP_1041.
PATRICi20532213. VBITrePal57110_1099.

Phylogenomic databases

eggNOGiENOG4108S10. Bacteria.
COG0740. LUCA.
KOiK01358.
OMAiNMIRFVK.
OrthoDBiEOG6Z3KQ0.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-1096-MONOMER.
BRENDAi3.4.21.92. 6429.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiCLPP2_TREPA
AccessioniPrimary (citable) accession number: O84003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: December 9, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.