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O83990 (UDP_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine phosphorylase

Short name=UPase
Short name=UrdPase
EC=2.4.2.3
Gene names
Name:udp
Ordered Locus Names:TP_1027
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activity

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processUMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

nucleotide catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuridine phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Uridine phosphorylase
PRO_0000063190

Sequences

Sequence LengthMass (Da)Tools
O83990 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 247ABA619316D72D

FASTA25827,920
        10         20         30         40         50         60 
MKLVYSTDCE YHIGLKASDI GHYVILPGDP ARSEKIAQHF SHPHKVGHNR EYVTYTGTLC 

        70         80         90        100        110        120 
ETPVSVMSTG IGGPSTAIGV EELIHLGAHT FIRVGTSGGM QPDILAGTVV IATGAIRFEG 

       130        140        150        160        170        180 
TSKEYAPVEF PAVPDFTVTA ALKHAAEDVQ VRHALGVVQC KDNFYGQHSP HTMPVHAELT 

       190        200        210        220        230        240 
QKWHAWIACN TLASEMESAA LFVLGSVRRV RTGAVLLVIG NQTRRAQGLE DIQVHDTENA 

       250 
IRVAVEAVKL LITQDSPR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65977.1.
PIRF71251.
RefSeqNP_219464.1. NC_000919.1.
YP_008091846.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83990.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243276.TP1027.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65977; AAC65977; TP_1027.
GeneID15852317.
2610897.
KEGGtpa:TP1027.
tpw:TPANIC_1027.
PATRIC20532183. VBITrePal57110_1084.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2820.
KOK00757.
OMAVVANQER.
OrthoDBEOG676Z3T.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-1082-MONOMER.
UniPathwayUPA00574; UER00633.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010058. Uridine_phosphorylase.
[Graphical view]
PANTHERPTHR21234. PTHR21234. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01718. Uridine-psphlse. 1 hit.
PROSITEPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDP_TREPA
AccessionPrimary (citable) accession number: O83990
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways