O83982 (GATC_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit C
Short name=Glu-ADT subunit C
EC=6.3.5.-

Gene names

Name:	gatC
Ordered Locus Names:	TP_1019

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) By similarity. HAMAP MF_00122
Catalytic activity	ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. HAMAP MF_00122 ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate. HAMAP MF_00122
Subunit structure	Heterotrimer of A, B and C subunits By similarity. HAMAP MF_00122
Sequence similarities	Belongs to the GatC family.
Sequence caution	The sequence AAC65969.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ligase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 114	114	Glutamyl-tRNA(Gln) amidotransferase subunit C HAMAP MF_00122		PRO_0000105355

Sequences

	Sequence		Length	Mass (Da)
	O83982 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: F25013CFAC01C509	FASTA	114	12,559
	10 20 30 40 50 60 MAQQRITSDI FAQLLTLSHL ESSECAVGLA TQIEDIIQYF SVVEQFDPGP RDDPDTDNAQ 70 80 90 100 110 GRCSQGNKID VDCCPDWVRK DVALPGLSVH DLKRLSTEFA DGYFRAPRAL DGSA

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000520 Genomic DNA. Translation: AAC65969.1. Different initiation.
PIR	G71253.
RefSeq	NP_219456.1. NC_000919.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O83982. 65 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2610871.
GenomeReviews	Gene locus TP_1019 in contig AE000520_GR.
KEGG	tpa:TP1019.
NMPDR	fig|243276.1.peg.1014.
PATRIC	20532165. VBITrePal57110_1075.
TIGR	TP_1019.
Phylogenomic databases
HOGENOM	HBG731894.
OMA	ESSECAV.
ProtClustDB	CLSK2300352.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_1019-MONOMER.
Family and domain databases
HAMAP	MF_00122. GatC. Divergent sequence. [Tree]
KO	K02435.
ProtoNet	Search...

Entry information

Entry name

GATC_TREPA

Accession

Primary (citable) accession number: O83982

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	January 25, 2012
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program