Reviewed,
UniProtKB/Swiss-Prot O83972 (RIR1_TREPA)
Last modified
November 3, 2009.
Version 64.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Ribonucleoside-diphosphate reductase subunit alpha EC=1.17.4.1 Alternative name(s): Ribonucleotide reductase | ||||
| Gene names |
| ||||
| Organism | Treponema pallidum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 160 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema |
Protein attributes
| Sequence length | 845 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. |
| Catalytic activity | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. |
| Pathway | |
| Subunit structure | Tetramer of two alpha and two beta subunits By similarity. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 ATP-cone domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Oxidoreductase |
| Technical term | Allosteric enzyme Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro ribonucleoside-diphosphate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 845 | 845 | Ribonucleoside-diphosphate reductase subunit alpha | PRO_0000187223 | |||||
Regions | |||||||||
| Domain | 1 – 98 | 98 | ATP-cone | ||||||
Sites | |||||||||
| Active site | 319 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 534 | 1 | Proton acceptor By similarity | ||||||
| Active site | 536 | 1 | Proton acceptor By similarity | ||||||
| Active site | 538 | 1 | Proton acceptor By similarity | ||||||
| Active site | 574 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 828 | 1 | Electron transfer By similarity | ||||||
| Active site | 829 | 1 | Electron transfer By similarity | ||||||
| Site | 326 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 356 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 840 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
| Site | 843 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K.  Venter J.C.Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
Cross-references
Sequence databases | |
|---|---|
| AE000520 Genomic DNA. Translation: AAC65956.1. | |
| PIR | B71255. |
| RefSeq | NP_219445.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O83972. 2 interactions. |
Genome annotation databases | |
| GeneID | 2610819. |
| GenomeReviews | Gene locus TP_1008 in contig AE000520_GR. |
| KEGG | tpa:TP1008. |
| NMPDR | fig|243276.1.peg.1003. |
| TIGR | TP_1008. |
Phylogenomic databases | |
| HOGENOM | O83972. |
| OMA | RHVDQSI. |
Enzyme and pathway databases | |
| BioCyc | TPAL243276:TP_1008-MON. |
| BRENDA | 1.17.4.1. 142600. |
Family and domain databases | |
| InterPro | IPR005144. ATP-cone. IPR013346. NrdE_NrdA. IPR013509. Ribncl_Rdtase_lsu_N. IPR000788. Ribncl_red_lg_C. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF03477. ATP-cone. 1 hit. PF02867. Ribonuc_red_lgC. 1 hit. PF00317. Ribonuc_red_lgN. 1 hit. [Graphical view] |
| PRINTS | PR01183. RIBORDTASEM1. |
| TIGRFAMs | TIGR02506. NrdE_NrdA. 1 hit. |
| PROSITE | PS51161. ATP_CONE. 1 hit. PS00089. RIBORED_LARGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIR1_TREPA | ||||||||
| Accession | Primary (citable) accession number: O83972 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
