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O83971 (THYX_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase thyX
Short name=TS
Short name=TSase
EC=2.1.1.148
Gene names
Name:thyX
Ordered Locus Names:TP_1007
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate By similarity. HAMAP MF_01408

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP+. HAMAP MF_01408

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_01408

Subunit structure

Homotetramer By similarity. HAMAP MF_01408

Sequence similarities

Belongs to the thymidylate synthase thyX family.

Contains 1 thyX (flavin-dependent thymidylate synthase) domain.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandFAD
Flavoprotein
NADP
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionflavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

thymidylate synthase (FAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Thymidylate synthase thyX HAMAP MF_01408
PRO_0000175583

Regions

Domain50 – 261212ThyX
Motif119 – 12911ThyX motif HAMAP MF_01408

Sequences

Sequence LengthMass (Da)Tools
O83971 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 6562EA1814B5D9FB

FASTA30534,186
        10         20         30         40         50         60 
MTLRTLQAGV AVSIALDRVC FFCYNGAVAH CVVEAAEDIL DRRFSVLDKG FVRLIDYLGG 

        70         80         90        100        110        120 
DARIVQAARV SYGAGTRTAR DDAALIDFLL RNKHTSPFEQ VVLTFHVRAP IFVARQWMRH 

       130        140        150        160        170        180 
RTARISEVSS RYSLLSHDCY VPQETSVAVQ STRNKQGRAS EGISPEQQQE VRAAFEAQQK 

       190        200        210        220        230        240 
AACAAYDALI QKNIARELAR INVPLSLYTE WYWQIDLHNL FHFLRLRASA HAQAEIRAYA 

       250        260        270        280        290        300 
EVIIEITRAV APCATASFEN HEKDGVQFSG REFAALKALL AGEGLSLEGK ERARFEEKLR 


SGLQQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000520 Genomic DNA. Translation: AAC65955.1.
PIRA71255.
RefSeqNP_219444.1. NC_000919.1.

3D structure databases

ProteinModelPortalO83971.
ModBaseSearch...

Protein-protein interaction databases

IntActO83971. 6 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2610808.
GenomeReviewsGene locus TP_1007 in contig AE000520_GR.
KEGGtpa:TP1007.
NMPDRfig|243276.1.peg.1002.
PATRIC20532139. VBITrePal57110_1062.
TIGRTP_1007.

Phylogenomic databases

HOGENOMHBG353106.
OMADHGFIRV.
ProtClustDBPRK00847.

Enzyme and pathway databases

BioCycTPAL243276:TP_1007-MONOMER.

Family and domain databases

HAMAPMF_01408. ThyX.
[Tree]
InterProIPR003669. Thymidylate_synthase_ThyX.
[Graphical view]
KOK03465.
PfamPF02511. Thy1. 1 hit.
[Graphical view]
SUPFAMSSF69796. Thy1. 1 hit.
TIGRFAMsTIGR02170. ThyX. 1 hit.
PROSITEPS51331. THYX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHYX_TREPA
AccessionPrimary (citable) accession number: O83971
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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