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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.By similarity

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei118By similarity1
Active sitei150By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA08.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidase (EC:3.4.23.36)
Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name:
SPase II
Gene namesi
Name:lspA
Synonyms:lsp
Ordered Locus Names:TP_0978
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001788291 – 186Lipoprotein signal peptidaseAdd BLAST186

Proteomic databases

PRIDEiO83943

Interactioni

Protein-protein interaction databases

IntActiO83943, 7 interactors
STRINGi243276.TP0978

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410835P Bacteria
COG0597 LUCA
KOiK03101
OMAiRAHNTGA

Family and domain databases

HAMAPiMF_00161 LspA, 1 hit
InterProiView protein in InterPro
IPR001872 Peptidase_A8
PANTHERiPTHR33695 PTHR33695, 1 hit
PfamiView protein in Pfam
PF01252 Peptidase_A8, 1 hit
PRINTSiPR00781 LIPOSIGPTASE
TIGRFAMsiTIGR00077 lspA, 1 hit
PROSITEiView protein in PROSITE
PS00855 SPASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O83943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTRIQKEK WIPLFAAGLV VVLDQCAKLL VGAYVPTNTS GVRVLGDFVR
60 70 80 90 100
IVHVYNVGAA FSIGHQLNQV LRTLVLGIVP LIIMFLIVFS YFRTDAFCPV
110 120 130 140 150
QRWAVSGIIG GGIGNLIDRF LRPNGVLDFI DVKFFGIFGF ERWPAFNIAD
160 170 180
AVIMTCGLLL IISFIKQEKE ISSQPSCNET GGVFRT
Length:186
Mass (Da):20,596
Last modified:May 29, 2007 - v2
Checksum:i39CC9B7FE8A8618E
GO

Sequence cautioni

The sequence AAC65933 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA Translation: AAC65933.1 Different initiation.
PIRiH71257

Genome annotation databases

EnsemblBacteriaiAAC65933; AAC65933; TP_0978
KEGGitpa:TP_0978

Similar proteinsi

Entry informationi

Entry nameiLSPA_TREPA
AccessioniPrimary (citable) accession number: O83943
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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