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O83856

- PNP_TREPA

UniProt

O83856 - PNP_TREPA

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, TP_0886
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841Magnesium By similarity
Metal bindingi490 – 4901Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-934-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:TP_0886
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329921Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0886.

Structurei

3D structure databases

ProteinModelPortaliO83856.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KH
Add
BLAST
Domaini620 – 68869S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83856-1 [UniParc]FASTAAdd to Basket

« Hide

MKHSITGTIG DHPLLLESGY LARQANGSVY LQCEGTAILA TVCSSAQRQE    50
GLDYVPLTVD FNEKYYAVGK MPGGFIKREG RPKDREILIS RLIDRPMRPL 100
FEKEFGRDIH VVPTCISSDM VHPHDVLAIV ASSAAVTLSD IPFHGPVAAV 150
RVAYLNGSYV INPTFSQIDA ASMEVVVAGT RQGITMVEGG AREVSEDLML 200
GALEQAQEHI KALCDMQERL RGLCGKEKQT VIPSSAQLVG RDRIYELAYP 250
RLAQALYAQG KGERRSACDA VKRDVAQQYA AQLENDVQRR LFDALFHEME 300
YEILRLNILD RGLRIDGRAI DAIRPIACEV GVLPRPHGSA VFTRGETQSL 350
AVVTLGAMSD GQVYDDIEGD RRENFILHYN FPPFSVGEIG RMGVGRREIG 400
HGCLAHRSLS AVIPDPEQFP YTVRVVSEIL ESNGSSSMAT VCSGTLSLLH 450
AGVPIKKPVA GIAMGLITDG VRYAILSDIL GEEDHLGDMD FKVAGTCDGI 500
TGFQMDVKVE AVSASLMKEA LQQARVGRLH ILSVMNQTIS APSVHISRYA 550
PHIESFKIAV EKIGALIGPG GKTVKSLSDQ YRVTINTDSD GTVTVSGRDA 600
QSVFDAKVAV VGLTEDPRVG RVYQGVVKRI VEFGAFVEIF PGKEGLCHVS 650
KLSRSRVSKV SDVLQEGQRI CVKLIDIDRM GRLNLSYIDA LEGKSGGLDT 700
TK 702
Length:702
Mass (Da):76,332
Last modified:November 1, 1998 - v1
Checksum:iBBE97F7E822B2960
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC26576.1.
PIRiC71269.
RefSeqiNP_219321.1. NC_000919.1.
YP_008091710.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC26576; AAC26576; TP_0886.
GeneIDi15852175.
2611780.
KEGGitpa:TP0886.
tpw:TPANIC_0886.
PATRICi20531881. VBITrePal57110_0938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC26576.1 .
PIRi C71269.
RefSeqi NP_219321.1. NC_000919.1.
YP_008091710.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83856.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243276.TP0886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC26576 ; AAC26576 ; TP_0886 .
GeneIDi 15852175.
2611780.
KEGGi tpa:TP0886.
tpw:TPANIC_0886.
PATRICi 20531881. VBITrePal57110_0938.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-934-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiPNP_TREPA
AccessioniPrimary (citable) accession number: O83856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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