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O83855

- DUT_TREPA

UniProt

O83855 - DUT_TREPA

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, TP_0885
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781Substrate By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-933-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:TP_0885
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000182913Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0885.

Structurei

3D structure databases

ProteinModelPortaliO83855.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 673Substrate binding By similarity
Regioni82 – 843Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
KOiK01520.
OMAiGETTANT.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

O83855-1 [UniParc]FASTAAdd to Basket

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MIRVRAVVYP GASFPEYQTL GSSGADLRAF LPGGPLEVHP LGRVLVPTGV    50
CVELPVGLEM QIRPRSGLAL EYGVTVLNSP GTIDADYRGE IRVLLVNLGL 100
AAFVVSHGDR IAQAVISSVL RVEYVRSGSI SLTERGKGGY GSTGVL 146
Length:146
Mass (Da):15,376
Last modified:November 1, 1998 - v1
Checksum:i561451F2BE54DE11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC26575.1.
PIRiB71269.
RefSeqiNP_219320.1. NC_000919.1.
YP_008091709.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC26575; AAC26575; TP_0885.
GeneIDi15852174.
2611438.
KEGGitpa:TP0885.
tpw:TPANIC_0885.
PATRICi20531879. VBITrePal57110_0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC26575.1 .
PIRi B71269.
RefSeqi NP_219320.1. NC_000919.1.
YP_008091709.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83855.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243276.TP0885.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC26575 ; AAC26575 ; TP_0885 .
GeneIDi 15852174.
2611438.
KEGGi tpa:TP0885.
tpw:TPANIC_0885.
PATRICi 20531879. VBITrePal57110_0937.

Phylogenomic databases

eggNOGi COG0756.
KOi K01520.
OMAi GETTANT.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci TPAL243276:GC1H-933-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiDUT_TREPA
AccessioniPrimary (citable) accession number: O83855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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