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O83833

- GLMS_TREPA

UniProt

O83833 - GLMS_TREPA

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, TP_0861
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei630 – 6301For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-909-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:TP_0861
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 635634Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135405Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0861.

Structurei

3D structure databases

ProteinModelPortaliO83833.
SMRiO83833. Positions 2-635.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2Add
BLAST
Domaini299 – 439141SIS 1Add
BLAST
Domaini472 – 625154SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiRIIICAC.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O83833-1 [UniParc]FASTAAdd to Basket

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MCGIVGMVAG RDVSGLLLEG LRRLEYRGYD SAGIAVVGSD CALRLLRCEG    50
RVQSLCALLG QSPLCGTMGI AHTRWATHGK PCAANAHPHC SESVAIVHNG 100
IVENHRSLRE MLVTRGYFFH SQTDSEVLAH LLHWELRYTA HLLLAVKKVL 150
TQVRGTYGLL CMDAASPGRL IAARSGSPLA VGLGCGENFV TSDPLALAHV 200
TQRFLYLEEG DIADVHRDSV CVHDAQGNVV ARPVVTYQMQ LCTQDKGTHR 250
HHMHQEIWQQ PHAIRHTLNA YMSFSSSSRA QVRTFGEDRV LDGTSCKTFE 300
RLFRRITRVR IIACGTSYHA GLVARYWFEA FAGVGCQVEI ASEYRYRTSV 350
VHAREIVLTI SQSGETADTI AALRLAKTQG YLCAIAICNG ARSTLVRESD 400
AVLLTHAGSE IGVASTKSFT TQLVCLLVLT RMIAQAKKIL TQEPEDALSA 450
ALQRLPQDVE HVLECEADVA RCARHFVHAQ HALFLGRGEL YPIAIESALK 500
LKEISYIHAE AYAAGELKHG PLALVDAQMP VVAIAPASPG VLFEKMASNI 550
EEVRARGGML YIFTDVPERF GPVCTPEADA PEGACSQIVT VPSVSPLTAP 600
IFYAVPLQLL AYHIALLKGT DIDQPRNLAK SVTVE 635
Length:635
Mass (Da):69,181
Last modified:January 23, 2007 - v3
Checksum:iDB84874078DE6AF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65824.1.
PIRiE71272.
RefSeqiNP_219297.1. NC_000919.1.
YP_008091685.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65824; AAC65824; TP_0861.
GeneIDi15852150.
2611074.
KEGGitpa:TP0861.
tpw:TPANIC_0861.
PATRICi20531831. VBITrePal57110_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65824.1 .
PIRi E71272.
RefSeqi NP_219297.1. NC_000919.1.
YP_008091685.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83833.
SMRi O83833. Positions 2-635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243276.TP0861.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65824 ; AAC65824 ; TP_0861 .
GeneIDi 15852150.
2611074.
KEGGi tpa:TP0861.
tpw:TPANIC_0861.
PATRICi 20531831. VBITrePal57110_0913.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi RIIICAC.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-909-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiGLMS_TREPA
AccessioniPrimary (citable) accession number: O83833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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