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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei630 – 6301For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-909-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:TP_0861
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 635634Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135405Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0861.

Structurei

3D structure databases

ProteinModelPortaliO83833.
SMRiO83833. Positions 2-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini299 – 439141SIS 1UniRule annotationAdd
BLAST
Domaini472 – 625154SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O83833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGMVAG RDVSGLLLEG LRRLEYRGYD SAGIAVVGSD CALRLLRCEG
60 70 80 90 100
RVQSLCALLG QSPLCGTMGI AHTRWATHGK PCAANAHPHC SESVAIVHNG
110 120 130 140 150
IVENHRSLRE MLVTRGYFFH SQTDSEVLAH LLHWELRYTA HLLLAVKKVL
160 170 180 190 200
TQVRGTYGLL CMDAASPGRL IAARSGSPLA VGLGCGENFV TSDPLALAHV
210 220 230 240 250
TQRFLYLEEG DIADVHRDSV CVHDAQGNVV ARPVVTYQMQ LCTQDKGTHR
260 270 280 290 300
HHMHQEIWQQ PHAIRHTLNA YMSFSSSSRA QVRTFGEDRV LDGTSCKTFE
310 320 330 340 350
RLFRRITRVR IIACGTSYHA GLVARYWFEA FAGVGCQVEI ASEYRYRTSV
360 370 380 390 400
VHAREIVLTI SQSGETADTI AALRLAKTQG YLCAIAICNG ARSTLVRESD
410 420 430 440 450
AVLLTHAGSE IGVASTKSFT TQLVCLLVLT RMIAQAKKIL TQEPEDALSA
460 470 480 490 500
ALQRLPQDVE HVLECEADVA RCARHFVHAQ HALFLGRGEL YPIAIESALK
510 520 530 540 550
LKEISYIHAE AYAAGELKHG PLALVDAQMP VVAIAPASPG VLFEKMASNI
560 570 580 590 600
EEVRARGGML YIFTDVPERF GPVCTPEADA PEGACSQIVT VPSVSPLTAP
610 620 630
IFYAVPLQLL AYHIALLKGT DIDQPRNLAK SVTVE
Length:635
Mass (Da):69,181
Last modified:January 23, 2007 - v3
Checksum:iDB84874078DE6AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65824.1.
PIRiE71272.
RefSeqiWP_010882305.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65824; AAC65824; TP_0861.
GeneIDi2611074.
KEGGitpa:TP0861.
tpw:TPANIC_0861.
PATRICi20531831. VBITrePal57110_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65824.1.
PIRiE71272.
RefSeqiWP_010882305.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83833.
SMRiO83833. Positions 2-635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0861.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65824; AAC65824; TP_0861.
GeneIDi2611074.
KEGGitpa:TP0861.
tpw:TPANIC_0861.
PATRICi20531831. VBITrePal57110_0913.

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiEOG6KT2Q1.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-909-MONOMER.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiGLMS_TREPA
AccessioniPrimary (citable) accession number: O83833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.