ID   O83826_TREPA            Unreviewed;      1533 AA.
AC   O83826;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=HAMP domain-containing protein {ECO:0000259|PROSITE:PS50885};
GN   OrderedLocusNames=TP_0854 {ECO:0000313|EMBL:AAC65822.1};
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65822.1, ECO:0000313|Proteomes:UP000000811};
RN   [1] {ECO:0000313|EMBL:AAC65822.1, ECO:0000313|Proteomes:UP000000811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols {ECO:0000313|EMBL:AAC65822.1,
RC   ECO:0000313|Proteomes:UP000000811};
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA   Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA   Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA   Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA   Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA   Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
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DR   EMBL; AE000520; AAC65822.1; -; Genomic_DNA.
DR   PIR; F71274; F71274.
DR   RefSeq; WP_010882298.1; NC_021490.2.
DR   STRING; 243276.TP_0854; -.
DR   EnsemblBacteria; AAC65822; AAC65822; TP_0854.
DR   KEGG; tpa:TP_0854; -.
DR   PATRIC; fig|243276.5.peg.905; -.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_243603_0_0_12; -.
DR   OrthoDB; 9763484at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..1533
FT                   /note="HAMP domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007697228"
FT   TRANSMEM        755..775
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        823..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        858..877
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1083..1107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1104..1161
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
SQ   SEQUENCE   1533 AA;  172871 MW;  2B077356F059EAD0 CRC64;
     MNARLCFFSR LIFCVLSICA LPLVAQEDKL YWEDPWALST ERAAFVKVAY SHDVVAVVWQ
     EVTPKNATSG EIRLSASFYD GSTWHTVRTF SPPLLYNHRS PSLASVAVNR KNEIFVAAAF
     DAHTITVFKT TDFGKSFTHT VLRSQGSDIV APYVSVASDD SLLLFASHGS EDHFSILLCR
     SEDGERWTPF QEFLSTEFSR RLFLPSHVST QAQEIVVFQA HHQEGERASY QLYSTVSFDQ
     GNTWSAPVPV TQPDEYHNQR PFLDRLSDDR FAVTWERSER TSTRYEMCYA ELDRYGRKIG
     TTLRLAEPSD RLITPNFVHI DGTTFCVWAG ESAGLNTIFL AQKKEGAWST TAVRSSEDAL
     LFPHAVRVDN HLEVFWQEGE GARARVMRLR PDQSVQPPTL IAENFSPNAV RKGTRARVRI
     VFPRDSSGIA GYNYAWQCGV QPAAPPDYVA HFPDKPQIEL EATQDGTWFL AVTVWDFAGN
     KSAPAYLSYT RGTTPAARPQ LQTPLLENTH ALKSNTFTLS WNQPSTDAQG NEERDHTSFL
     WSLQQVAPLS ALTSLRVDTD VRTFEEFQQR CVRAFPIPVD VHGTRSRQSS VSFTNKENGI
     YRFSVYALDR SGNVSEPAVV FFALRHFVPY TAIRYVDVKK DPAGSLQMSI VGNGFRAQGT
     VSQVYIDRDR KAPYDLVLHA QEFAVGSDNL ISDIHIDNLK KGSYHVGVWH PARGVHFAES
     RVTVSEMGTV KFGAYDYEHQ VRWSIPHTGG LRVNFVSLFM LIALFLAGVV FAASLTRIGD
     IVGEAFVLKK QVEALMIGEL MPSEKRRKAM ALKTHGAGLR VKFILFALTL VISVIFIVSV
     PLGVRFSKTQ KDLLAKNLFS RVQVLLESLV AAGKVYLPAK NKLELGFLPN QTTALHEARY
     AVITGESEEP HEEGIDFVWA TNFSDIETVL NEPEYRQGNS RFVDKRIAQI LPAMEDLNRQ
     VKKDAEKIAK GIADLTQEAV ALALRTDQGS VRRRDDIQSI TRQMDQRLLE IFSTFSNNAV
     GSYPEYRVDN LSKRHSSYLF YKPILYRQRG HADSFVHGVV FVEVSTQELL EHIEGLQRDL
     IKMVFYVSLI ALACGVFGAW ILASIIIKPI RRLASHVAMI RDTEKKEELE GKLIAIKGQD
     EIALLGRTIN DMTEGLIKAA LASKDLTVGK EIQKMFIPLD TNTEGRKLTS GYTCDDHVEF
     FGYYEGALGV SGDYFDYIKL DDQHYAIIKC DVAGKGVPAA LIMVEVATLF QNFFKDWNIQ
     SHGINLSDIV SRINDLIEAR GFKGRFAAFT LCIFNTVSGT VHFCNAGDNI IHIYDAQQRK
     MKRITLAQTS AAGVFPSFMI DMKGGFGVET LTLRTGDVLF LYTDGIEEAK RLFRNKRFEL
     VLCQEQGLAH DAPHETHTVG QAGEELGAER VSSIIESVFL RKGFSLQKWH NPVEGEKFEF
     DFSSCEGNLD EAVLALVAVE QVFRMYKHPR ATNLDKIRVD KKVDMFLARY FVQYPEYCAR
     KEVNSEYEEY LYYTFIKEDD QYDDLTILGI RKR
//