O83814 (AMPM_TREPA) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Methionine aminopeptidase Short name=MAP EC=3.4.11.18 Alternative name(s): Peptidase M | ||||
| Gene names |
| ||||
| Organism | Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 243276 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema › ![]() |
Protein attributes
| Sequence length | 255 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Removes the N-terminal methionine from nascent proteins. |
| Catalytic activity | Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. |
| Cofactor | Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity. |
| Sequence similarities | Belongs to the peptidase M24A family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Cobalt Metal-binding |
| Molecular function | Aminopeptidase Hydrolase Protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | cellular process Inferred from electronic annotation. Source: InterPro proteolysisInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular_function | aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 255 | 255 | Methionine aminopeptidase | PRO_0000148966 | |||||
Sites | |||||||||
| Metal binding | 93 | 1 | Cobalt 1 By similarity | ||||||
| Metal binding | 104 | 1 | Cobalt 1 By similarity | ||||||
| Metal binding | 104 | 1 | Cobalt 2 By similarity | ||||||
| Metal binding | 167 | 1 | Cobalt 2 By similarity | ||||||
| Metal binding | 201 | 1 | Cobalt 2 By similarity | ||||||
| Metal binding | 232 | 1 | Cobalt 1 By similarity | ||||||
| Metal binding | 232 | 1 | Cobalt 2 By similarity | ||||||
| Binding site | 76 | 1 | Substrate By similarity | ||||||
| Binding site | 174 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. Venter J.C.Science 281:375-388(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000520 Genomic DNA. Translation: AAC65810.1. |
| PIR | B71273. |
| RefSeq | NP_219278.1. NC_000919.1. |
3D structure databases | |
| ProteinModelPortal | O83814. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O83814. 7 interactions. |
| STRING | 243276.TP0842. |
Protein family/group databases | |
| MEROPS | M24.001. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAC65810; AAC65810; TP_0842. |
| GeneID | 2611002. |
| KEGG | tpa:TP0842. |
| PATRIC | 20531791. VBITrePal57110_0893. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0024. |
| KO | K01265. |
| OMA | IETETRA. |
| ProtClustDB | CLSK218891. |
Family and domain databases | |
| Gene3D | 3.90.230.10. 1 hit. |
| InterPro | IPR001714. Pept_M24_MAP. IPR000994. Pept_M24_structural-domain. IPR002467. Pept_M24A_MAP1. [Graphical view] |
| Pfam | PF00557. Peptidase_M24. 1 hit. [Graphical view] |
| PRINTS | PR00599. MAPEPTIDASE. |
| SUPFAM | SSF55920. Peptidase_M24_cat_core. 1 hit. |
| TIGRFAMs | TIGR00500. met_pdase_I. 1 hit. |
| PROSITE | PS00680. MAP_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AMPM_TREPA | ||||||||
| Accession | Primary (citable) accession number: O83814 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with
