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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:TP_0831
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516301 – 589Arginine--tRNA ligaseAdd BLAST589

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiO83803. 4 interactors.
STRINGi243276.TP0831.

Structurei

3D structure databases

ProteinModelPortaliO83803.
SMRiO83803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 142"HIGH" regionAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
KOiK01887.
OMAiNKPLHLG.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

O83803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDLCEMWRH AVARVLSQLQ GPAVEPVEGA QLVMEEPPEP GMGDIAFPLF
60 70 80 90 100
LFAKRVRRSP AQLAQQLCTL LEEDTSMCAY GTPQARGPYL NVFLNKECVA
110 120 130 140 150
AHTLDAIFAQ GERYGHTQYL QGKRIMVEFS SPNTNKPLHV GHLRNNAIGE
160 170 180 190 200
SLSRIIAFCG ADVFKVNIIN DRGVHICKSM CAYQKFAHGK TPAHTGIKSD
210 220 230 240 250
RFVGDWYVQF NRYAQQYPEE AEHDVRDLLQ RWESADPHVR ALWRTMNEWA
260 270 280 290 300
LRGIKQTYER TGISFDKLYF ESETYTKGRE EVRRGLACGV FYQMEDNSIW
310 320 330 340 350
VDLSSLGLDK KALLRSDGTT MYITQDIGTA IFRAQDWPFD QLLYVVGNEQ
360 370 380 390 400
NYHFKVLFFV LRLLGYPWAQ QLHHVSYGMV NLPHGRMKSR EGTVVDADDI
410 420 430 440 450
LDRLHSAAEE EIAKKGRENA LKHAQCIAEN VAIAALHYFL LQVSPQKDMV
460 470 480 490 500
FHPEESLSFN GNTGPYLQYM GARISSLLKK VQEDVEQKGP REVRCDPALL
510 520 530 540 550
THEAEWELVK ALARFPACVT RAAQGHDPSV ITGYLYTLSK SFSRFYHDCP
560 570 580
ILCEARPDYA CARLELVRAV RIVLRTAMRL VLIPFLEEM
Length:589
Mass (Da):67,132
Last modified:November 1, 1998 - v1
Checksum:iFA6156A69F4568E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65797.1.
PIRiA71277.
RefSeqiWP_010882275.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65797; AAC65797; TP_0831.
GeneIDi2610958.
KEGGitpa:TP_0831.

Similar proteinsi

Entry informationi

Entry nameiSYR_TREPA
AccessioniPrimary (citable) accession number: O83803
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families