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O83790 (TRXB_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thioredoxin reductase

Short name=TRXR
EC=1.8.1.9
Gene names
Name:trxB
Ordered Locus Names:TP_0814
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processremoval of superoxide radicals

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionflavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

thioredoxin-disulfide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Thioredoxin reductase
PRO_0000166754

Regions

Nucleotide binding34 – 418FAD By similarity
Nucleotide binding275 – 28410FAD By similarity

Amino acid modifications

Disulfide bond134 ↔ 137Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
O83790 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 2519A5BA3BB4E012

FASTA30732,868
        10         20         30         40         50         60 
METDYDVIIV GAGAAGLSAA QYACRANLRT LVIESKAHGG QALLIDSLEN YPGYATPISG 

        70         80         90        100        110        120 
FEYAENMKKQ AVAFGAQIAY EEVTTIGKRD SVFHITTGTG AYTAMSVILA TGAEHRKMGI 

       130        140        150        160        170        180 
PGESEFLGRG VSYCATCDGP FFRNKHVVVI GGGDAACDES LVLSRLTDRV TMIHRRDTLR 

       190        200        210        220        230        240 
AQKAIAERTL KNPHIAVQWN TTLEAVRGET KVSSVLLKDV KTGETRELAC DAVFFFIGMV 

       250        260        270        280        290        300 
PITGLLPDAE KDSTGYIVTD DEMRTSVEGI FAAGDVRAKS FRQVITATSD GALAAHAAAS 


YIDTLQN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65780.1.
PIRC71278.
RefSeqNP_219250.1. NC_000919.1.

3D structure databases

ProteinModelPortalO83790.
ModBaseSearch...

Protein-protein interaction databases

IntActO83790. 9 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2610892.
GenomeReviewsGene locus TP_0814 in contig AE000520_GR.
KEGGtpa:TP0814.
NMPDRfig|243276.1.peg.809.
PATRIC20531727. VBITrePal57110_0861.
TIGRTP_0814.

Phylogenomic databases

HOGENOMHBG669726.
OMAGGQMLMT.
ProtClustDBCLSK2300308.

Enzyme and pathway databases

BioCycTPAL243276:TP_0814-MONOMER.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
KOK00384.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
TIGRFAMsTIGR01292. TRX_reduct. 1 hit.
PROSITEPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRXB_TREPA
AccessionPrimary (citable) accession number: O83790
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families