O83790 (TRXB_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	TP_0814

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Thioredoxin reductase		PRO_0000166754
Regions
	Nucleotide binding	34 – 41	8	FAD By similarity
	Nucleotide binding	275 – 284	10	FAD By similarity
Amino acid modifications
	Disulfide bond	134 ↔ 137		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83790 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 2519A5BA3BB4E012	FASTA	307	32,868
	10 20 30 40 50 60 METDYDVIIV GAGAAGLSAA QYACRANLRT LVIESKAHGG QALLIDSLEN YPGYATPISG 70 80 90 100 110 120 FEYAENMKKQ AVAFGAQIAY EEVTTIGKRD SVFHITTGTG AYTAMSVILA TGAEHRKMGI 130 140 150 160 170 180 PGESEFLGRG VSYCATCDGP FFRNKHVVVI GGGDAACDES LVLSRLTDRV TMIHRRDTLR 190 200 210 220 230 240 AQKAIAERTL KNPHIAVQWN TTLEAVRGET KVSSVLLKDV KTGETRELAC DAVFFFIGMV 250 260 270 280 290 300 PITGLLPDAE KDSTGYIVTD DEMRTSVEGI FAAGDVRAKS FRQVITATSD GALAAHAAAS YIDTLQN

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000520 Genomic DNA. Translation: AAC65780.1.
PIR	C71278.
RefSeq	NP_219250.1. NC_000919.1.
3D structure databases
ProteinModelPortal	O83790.
ModBase	Search...
Protein-protein interaction databases
IntAct	O83790. 9 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2610892.
GenomeReviews	Gene locus TP_0814 in contig AE000520_GR.
KEGG	tpa:TP0814.
NMPDR	fig|243276.1.peg.809.
PATRIC	20531727. VBITrePal57110_0861.
TIGR	TP_0814.
Phylogenomic databases
HOGENOM	HBG669726.
OMA	GGQMLMT.
ProtClustDB	CLSK2300308.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0814-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_TREPA

Accession

Primary (citable) accession number: O83790

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program