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O83779

- O83779_TREPA

UniProt

O83779 - O83779_TREPA

Protein
Submitted name:

ATP-dependent Clp protease subunit A (ClpA)

Gene

clpA2

Organism
Treponema pallidum (strain Nichols)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent peptidase activity Source: InterPro

    Keywords - Molecular functioni

    ChaperoneUniRule annotationSAAS annotation, Hydrolase, ProteaseImported

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-849-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-dependent Clp protease subunit A (ClpA)Imported
    Submitted name:
    S14 family endopeptidase ClpAImported (EC:3.4.21.92Imported)
    Gene namesi
    Name:clpA2Imported
    Ordered Locus Names:TP_0801Imported
    ORF Names:TPANIC_0801Imported
    OrganismiTreponema pallidum (strain Nichols)Imported
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi243276.TP0801.

    Structurei

    3D structure databases

    SMRiO83779. Positions 208-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the clpA/clpB family.UniRule annotation

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    KOiK03694.
    OMAiKISARTI.
    OrthoDBiEOG65F8SM.

    Family and domain databases

    Gene3Di1.10.1780.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004176. Clp_N.
    IPR013461. ClpA.
    IPR001270. ClpA/B.
    IPR018368. ClpA/B_CS1.
    IPR028299. ClpA/B_CS2.
    IPR023150. Dbl_Clp-N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11638:SF14. PTHR11638:SF14. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF02861. Clp_N. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    PRINTSiPR00300. CLPPROTEASEA.
    SMARTiSM00382. AAA. 2 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR02639. ClpA. 1 hit.
    PROSITEiPS00870. CLPAB_1. 1 hit.
    PS00871. CLPAB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIIISASVQ IILDQAFDLA RKRRHEYITA EHVLFSALAH PAALEIINLC    50
    SADIALIHSN LSEFLKTQVP VDLSHTPSQS LGFQHLLKRA VLYCEANKKS 100
    ALEVGDLLVS LLQAETNYAS YYMRMSGMST ARLIEVIARV NGIRHGDKNV 150
    SMGSNAQERY SESDDVGESA GHGPPLDGTE GDGNTADVHV HYEHCAHKRT 200
    DADTHRYTVL EKYTVNLTER ARRGELAPLI GRTQEIERTI QILCRRQKNN 250
    PVHVGEAGVG KTAITEGLAQ RIVRCDVPEA LEGVEIFSLD MTSLLAGTKF 300
    RGDFEERLKR LAEELEKKTQ AILFIDEIHT VVGTGSGGSG GLDASNLLKP 350
    LLSSGKIRCI GSTTYEEYTK HFRKDQALAR RFQKIDIEEP SEEETLRILE 400
    GIRTLYEDFH AVHYSDEALA AAVRLSVQYI QGRHLPDKAI DIIDEAGACA 450
    KLSRGKHGTE GVCSVIGESD IDEIVAKIAK IPKQRVSASE IEKLRNFERS 500
    ISEKIFGQGE AIDLVTRTLK RARVGLRVKH KPIANLLFVG ATGVGKTELA 550
    RTLAQELGIV LHRFDMSEYQ EKHTVSRLIG SPPGYVGFEE GGLLTDAVRK 600
    QPHAVLLLDE IEKAHPDIFN VLLQVMDYAT LTDNQGRKAD FRNVILIMTS 650
    NAGARNMGVS LIGFHKGQVG TAVIDEAVER IFSPEFRNRL DAVIRFDALS 700
    LETMERIARK ELALVCEQLQ KKHIRFDITD DALALLAERS HSGGSGARNV 750
    ARLVEQEVAN VLADLMLFGG VAEGDALRCT VKDRHAQCNF LRIECVQSSY 800
    SGSIQDALG 809
    Length:809
    Mass (Da):89,328
    Last modified:November 1, 1998 - v1
    Checksum:iD9C8CBEE250CAEEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65770.1.
    CP004010 Genomic DNA. Translation: AGN75973.1.
    PIRiC71279.
    RefSeqiNP_219238.1. NC_000919.1.
    YP_008091628.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65770; AAC65770; TP_0801.
    AGN75973; AGN75973; TPANIC_0801.
    GeneIDi15852092.
    2610835.
    KEGGitpa:TP0801.
    tpw:TPANIC_0801.
    PATRICi20531697. VBITrePal57110_0846.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65770.1 .
    CP004010 Genomic DNA. Translation: AGN75973.1 .
    PIRi C71279.
    RefSeqi NP_219238.1. NC_000919.1.
    YP_008091628.1. NC_021490.2.

    3D structure databases

    SMRi O83779. Positions 208-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243276.TP0801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65770 ; AAC65770 ; TP_0801 .
    AGN75973 ; AGN75973 ; TPANIC_0801 .
    GeneIDi 15852092.
    2610835.
    KEGGi tpa:TP0801.
    tpw:TPANIC_0801.
    PATRICi 20531697. VBITrePal57110_0846.

    Phylogenomic databases

    KOi K03694.
    OMAi KISARTI.
    OrthoDBi EOG65F8SM.

    Enzyme and pathway databases

    BioCyci TPAL243276:GC1H-849-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1780.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004176. Clp_N.
    IPR013461. ClpA.
    IPR001270. ClpA/B.
    IPR018368. ClpA/B_CS1.
    IPR028299. ClpA/B_CS2.
    IPR023150. Dbl_Clp-N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11638:SF14. PTHR11638:SF14. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF02861. Clp_N. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    PRINTSi PR00300. CLPPROTEASEA.
    SMARTi SM00382. AAA. 2 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR02639. ClpA. 1 hit.
    PROSITEi PS00870. CLPAB_1. 1 hit.
    PS00871. CLPAB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NicholsImported.
    2. "Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: Correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters."
      Petrosova H., Pospisilova P., Strouhal M., Cejkova D., Zobanikova M., Mikalova L., Sodergren E., Weinstock G.M., Smajs D.
      PLoS ONE 8:E74319-E74319(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NicholsImported.

    Entry informationi

    Entry nameiO83779_TREPA
    AccessioniPrimary (citable) accession number: O83779
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3