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O83774

- APBE_TREPA

UniProt

O83774 - APBE_TREPA

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Protein
Thiamine biosynthesis lipoprotein ApbE
Gene
apbE, TP_0796
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine By similarity.

Pathwayi

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Thiamine biosynthesis

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-844-MONOMER.
UniPathwayiUPA00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine biosynthesis lipoprotein ApbE
Gene namesi
Name:apbE
Ordered Locus Names:TP_0796
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cell membrane; Lipid-anchor Reviewed prediction

GO - Cellular componenti

  1. periplasmic space Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 362340Thiamine biosynthesis lipoprotein ApbE
PRO_0000001751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi23 – 231N-palmitoyl cysteine Reviewed prediction
Lipidationi23 – 231S-diacylglycerol cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0796.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 389
Beta strandi41 – 499
Helixi53 – 7422
Beta strandi79 – 813
Helixi82 – 887
Turni89 – 913
Beta strandi95 – 973
Helixi99 – 11416
Turni115 – 1173
Helixi124 – 13512
Helixi142 – 1498
Helixi154 – 1563
Beta strandi157 – 1615
Beta strandi169 – 1735
Turni183 – 1853
Helixi186 – 20015
Beta strandi206 – 2105
Beta strandi213 – 2186
Beta strandi234 – 2385
Beta strandi245 – 2473
Beta strandi249 – 26315
Beta strandi266 – 2716
Beta strandi274 – 2785
Turni282 – 2843
Beta strandi285 – 2873
Beta strandi293 – 3008
Helixi302 – 31514
Helixi317 – 3248
Beta strandi331 – 3355
Beta strandi339 – 3435
Turni345 – 3473
Helixi348 – 3503
Beta strandi351 – 3533
Beta strandi358 – 3603

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFUX-ray1.83A23-362[»]
4IFWX-ray2.30A23-362[»]
4IFXX-ray1.45A23-362[»]
4IFZX-ray1.90A23-362[»]
4IG1X-ray1.43A23-362[»]
ProteinModelPortaliO83774.

Family & Domainsi

Sequence similaritiesi

Belongs to the ApbE family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1477.
KOiK03734.
OMAiELMAINH.
OrthoDBiEOG6CGCF7.

Family and domain databases

InterProiIPR003374. ApbE.
IPR024932. Thiamine_synth_ApbE.
[Graphical view]
PfamiPF02424. ApbE. 1 hit.
[Graphical view]
PIRSFiPIRSF006268. ApbE. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O83774-1 [UniParc]FASTAAdd to Basket

« Hide

MKSSCVYWRI GVLVCILCGV GSCGGRARVR EYSRAELVIG TLCRVRVYSK    50
RPAAEVHAAL EEVFTLLQQQ EMVLSANRDD SALAALNAQA GSAPVVVDRS 100
LYALLERALF FAEKSGGAFN PALGAXVKLW NIGFDRAAVP DPDALKEALT 150
RCDFRQVHLR AGVSVGAPHT VQLAQAGMQL DLGAIAKGFL ADKIVQLLTA 200
HALDSALVDL GGNIFALGLK YGDVRSAAAQ RLEWNVGIRD PHGTGQKPAL 250
VVSVRDCSVV TSGAYERFFE RDGVRYHHII DPVTGFPAHT DVDSVSIFAP 300
RSTDADALAT ACFVLGYEKS CALLREFPGV DALFIFPDKR VRASAGIVDR 350
VRVLDARFVL ER 362
Length:362
Mass (Da):39,064
Last modified:November 1, 1998 - v1
Checksum:iE64E2FAFD1A7041C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65759.1.
PIRiC71281.
RefSeqiNP_219233.1. NC_000919.1.

Genome annotation databases

EnsemblBacteriaiAAC65759; AAC65759; TP_0796.
GeneIDi2610802.
KEGGitpa:TP0796.
PATRICi20531687. VBITrePal57110_0841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65759.1 .
PIRi C71281.
RefSeqi NP_219233.1. NC_000919.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IFU X-ray 1.83 A 23-362 [» ]
4IFW X-ray 2.30 A 23-362 [» ]
4IFX X-ray 1.45 A 23-362 [» ]
4IFZ X-ray 1.90 A 23-362 [» ]
4IG1 X-ray 1.43 A 23-362 [» ]
ProteinModelPortali O83774.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243276.TP0796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65759 ; AAC65759 ; TP_0796 .
GeneIDi 2610802.
KEGGi tpa:TP0796.
PATRICi 20531687. VBITrePal57110_0841.

Phylogenomic databases

eggNOGi COG1477.
KOi K03734.
OMAi ELMAINH.
OrthoDBi EOG6CGCF7.

Enzyme and pathway databases

UniPathwayi UPA00060 .
BioCyci TPAL243276:GC1H-844-MONOMER.

Family and domain databases

InterProi IPR003374. ApbE.
IPR024932. Thiamine_synth_ApbE.
[Graphical view ]
Pfami PF02424. ApbE. 1 hit.
[Graphical view ]
PIRSFi PIRSF006268. ApbE. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiAPBE_TREPA
AccessioniPrimary (citable) accession number: O83774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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