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O83774 (APBE_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine biosynthesis lipoprotein ApbE
Gene names
Name:apbE
Ordered Locus Names:TP_0796
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine By similarity.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Subcellular location

Cell membrane; Lipid-anchor Potential.

Sequence similarities

Belongs to the ApbE family.

Ontologies

Keywords
   Biological processThiamine biosynthesis
   Cellular componentCell membrane
Membrane
   DomainSignal
   PTMLipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processthiamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

thiamine diphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentperiplasmic space

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 362340Thiamine biosynthesis lipoprotein ApbE
PRO_0000001751

Amino acid modifications

Lipidation231N-palmitoyl cysteine Potential
Lipidation231S-diacylglycerol cysteine Potential

Secondary structure

............................................................. 362
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O83774 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: E64E2FAFD1A7041C

FASTA36239,064
        10         20         30         40         50         60 
MKSSCVYWRI GVLVCILCGV GSCGGRARVR EYSRAELVIG TLCRVRVYSK RPAAEVHAAL 

        70         80         90        100        110        120 
EEVFTLLQQQ EMVLSANRDD SALAALNAQA GSAPVVVDRS LYALLERALF FAEKSGGAFN 

       130        140        150        160        170        180 
PALGAXVKLW NIGFDRAAVP DPDALKEALT RCDFRQVHLR AGVSVGAPHT VQLAQAGMQL 

       190        200        210        220        230        240 
DLGAIAKGFL ADKIVQLLTA HALDSALVDL GGNIFALGLK YGDVRSAAAQ RLEWNVGIRD 

       250        260        270        280        290        300 
PHGTGQKPAL VVSVRDCSVV TSGAYERFFE RDGVRYHHII DPVTGFPAHT DVDSVSIFAP 

       310        320        330        340        350        360 
RSTDADALAT ACFVLGYEKS CALLREFPGV DALFIFPDKR VRASAGIVDR VRVLDARFVL 


ER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65759.1.
PIRC71281.
RefSeqNP_219233.1. NC_000919.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFUX-ray1.83A23-362[»]
4IFWX-ray2.30A23-362[»]
4IFXX-ray1.45A23-362[»]
4IFZX-ray1.90A23-362[»]
4IG1X-ray1.43A23-362[»]
ProteinModelPortalO83774.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243276.TP0796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65759; AAC65759; TP_0796.
GeneID2610802.
KEGGtpa:TP0796.
PATRIC20531687. VBITrePal57110_0841.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1477.
KOK03734.
OMAELMAINH.
OrthoDBEOG6CGCF7.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-844-MONOMER.
UniPathwayUPA00060.

Family and domain databases

InterProIPR003374. ApbE.
IPR024932. Thiamine_synth_ApbE.
[Graphical view]
PfamPF02424. ApbE. 1 hit.
[Graphical view]
PIRSFPIRSF006268. ApbE. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPBE_TREPA
AccessionPrimary (citable) accession number: O83774
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways