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O83774

- APBE_TREPA

UniProt

O83774 - APBE_TREPA

Protein

Thiamine biosynthesis lipoprotein ApbE

Gene

apbE

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine.By similarity

    Pathwayi

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Thiamine biosynthesis

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-844-MONOMER.
    UniPathwayiUPA00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamine biosynthesis lipoprotein ApbE
    Gene namesi
    Name:apbE
    Ordered Locus Names:TP_0796
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Subcellular locationi

    Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. periplasmic space Source: InterPro
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222PROSITE-ProRule annotationAdd
    BLAST
    Chaini23 – 362340Thiamine biosynthesis lipoprotein ApbEPRO_0000001751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi23 – 231N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi23 – 231S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi243276.TP0796.

    Structurei

    Secondary structure

    1
    362
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 389
    Beta strandi41 – 499
    Helixi53 – 7422
    Beta strandi79 – 813
    Helixi82 – 887
    Turni89 – 913
    Beta strandi95 – 973
    Helixi99 – 11416
    Turni115 – 1173
    Helixi124 – 13512
    Helixi142 – 1498
    Helixi154 – 1563
    Beta strandi157 – 1615
    Beta strandi169 – 1735
    Turni183 – 1853
    Helixi186 – 20015
    Beta strandi206 – 2105
    Beta strandi213 – 2186
    Beta strandi234 – 2385
    Beta strandi245 – 2473
    Beta strandi249 – 26315
    Beta strandi266 – 2716
    Beta strandi274 – 2785
    Turni282 – 2843
    Beta strandi285 – 2873
    Beta strandi293 – 3008
    Helixi302 – 31514
    Helixi317 – 3248
    Beta strandi331 – 3355
    Beta strandi339 – 3435
    Turni345 – 3473
    Helixi348 – 3503
    Beta strandi351 – 3533
    Beta strandi358 – 3603

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IFUX-ray1.83A23-362[»]
    4IFWX-ray2.30A23-362[»]
    4IFXX-ray1.45A23-362[»]
    4IFZX-ray1.90A23-362[»]
    4IG1X-ray1.43A23-362[»]
    ProteinModelPortaliO83774.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ApbE family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1477.
    KOiK03734.
    OMAiELMAINH.
    OrthoDBiEOG6CGCF7.

    Family and domain databases

    InterProiIPR003374. ApbE.
    IPR024932. Thiamine_synth_ApbE.
    [Graphical view]
    PfamiPF02424. ApbE. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006268. ApbE. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O83774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSSCVYWRI GVLVCILCGV GSCGGRARVR EYSRAELVIG TLCRVRVYSK    50
    RPAAEVHAAL EEVFTLLQQQ EMVLSANRDD SALAALNAQA GSAPVVVDRS 100
    LYALLERALF FAEKSGGAFN PALGAXVKLW NIGFDRAAVP DPDALKEALT 150
    RCDFRQVHLR AGVSVGAPHT VQLAQAGMQL DLGAIAKGFL ADKIVQLLTA 200
    HALDSALVDL GGNIFALGLK YGDVRSAAAQ RLEWNVGIRD PHGTGQKPAL 250
    VVSVRDCSVV TSGAYERFFE RDGVRYHHII DPVTGFPAHT DVDSVSIFAP 300
    RSTDADALAT ACFVLGYEKS CALLREFPGV DALFIFPDKR VRASAGIVDR 350
    VRVLDARFVL ER 362
    Length:362
    Mass (Da):39,064
    Last modified:November 1, 1998 - v1
    Checksum:iE64E2FAFD1A7041C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65759.1.
    PIRiC71281.
    RefSeqiNP_219233.1. NC_000919.1.

    Genome annotation databases

    EnsemblBacteriaiAAC65759; AAC65759; TP_0796.
    GeneIDi2610802.
    KEGGitpa:TP0796.
    PATRICi20531687. VBITrePal57110_0841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65759.1 .
    PIRi C71281.
    RefSeqi NP_219233.1. NC_000919.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IFU X-ray 1.83 A 23-362 [» ]
    4IFW X-ray 2.30 A 23-362 [» ]
    4IFX X-ray 1.45 A 23-362 [» ]
    4IFZ X-ray 1.90 A 23-362 [» ]
    4IG1 X-ray 1.43 A 23-362 [» ]
    ProteinModelPortali O83774.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243276.TP0796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65759 ; AAC65759 ; TP_0796 .
    GeneIDi 2610802.
    KEGGi tpa:TP0796.
    PATRICi 20531687. VBITrePal57110_0841.

    Phylogenomic databases

    eggNOGi COG1477.
    KOi K03734.
    OMAi ELMAINH.
    OrthoDBi EOG6CGCF7.

    Enzyme and pathway databases

    UniPathwayi UPA00060 .
    BioCyci TPAL243276:GC1H-844-MONOMER.

    Family and domain databases

    InterProi IPR003374. ApbE.
    IPR024932. Thiamine_synth_ApbE.
    [Graphical view ]
    Pfami PF02424. ApbE. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006268. ApbE. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiAPBE_TREPA
    AccessioniPrimary (citable) accession number: O83774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3