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O83754 (END3_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease III

EC=4.2.99.18
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyase
Gene names
Name:nth
Ordered Locus Names:TP_0775
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity. HAMAP-Rule MF_00942

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00942

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP-Rule MF_00942

Sequence similarities

Belongs to the Nth/MutY family.

Contains 1 HhH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Endonuclease III HAMAP-Rule MF_00942
PRO_0000102225

Regions

Domain111 – 13020HhH

Sites

Metal binding1901Iron-sulfur (4Fe-4S) By similarity
Metal binding1971Iron-sulfur (4Fe-4S) By similarity
Metal binding2001Iron-sulfur (4Fe-4S) By similarity
Metal binding2061Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
O83754 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: E6CA4C35DA370BAD

FASTA21123,419
        10         20         30         40         50         60 
MRLLDSKGVH AVFEQLHAAN PQPQGELHWR NTFTLLVAVL LSAQATDKSV NKATAALFDV 

        70         80         90        100        110        120 
ADTPQAMLAL GEERLCSYIR TINLYPTKAR RIIALSAELI ERFAAQVPCD AHALESLPGV 

       130        140        150        160        170        180 
GHKTANVVLN MGFGIPTIAV DTHILRTAPR IGLSSGRTPR AVERDLLVVT PREFRMHAHH 

       190        200        210 
WILLHGRYTC TARRPRCTEC CLRDLCCKNN I 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65744.1.
PIRH71281.
RefSeqNP_219212.1. NC_000919.1.
YP_008091603.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83754.
SMRO83754. Positions 7-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243276.TP0775.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65744; AAC65744; TP_0775.
GeneID15852067.
2611450.
KEGGtpa:TP0775.
tpw:TPANIC_0775.
PATRIC20531643. VBITrePal57110_0819.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0177.
KOK10773.
OMARSPACER.
OrthoDBEOG6H4KC5.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-823-MONOMER.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPMF_00942. Nth.
InterProIPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF001435. Nth. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
TIGRFAMsTIGR01083. nth. 1 hit.
PROSITEPS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEND3_TREPA
AccessionPrimary (citable) accession number: O83754
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families