ID   O83745_TREPA            Unreviewed;       391 AA.
AC   O83745;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=HD-GYP domain-containing protein {ECO:0000259|PROSITE:PS51832};
GN   OrderedLocusNames=TP_0764 {ECO:0000313|EMBL:AAC65727.1};
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65727.1, ECO:0000313|Proteomes:UP000000811};
RN   [1] {ECO:0000313|EMBL:AAC65727.1, ECO:0000313|Proteomes:UP000000811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols {ECO:0000313|EMBL:AAC65727.1,
RC   ECO:0000313|Proteomes:UP000000811};
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA   Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA   Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA   Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA   Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA   Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
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DR   EMBL; AE000520; AAC65727.1; -; Genomic_DNA.
DR   PIR; G71285; G71285.
DR   RefSeq; WP_010882209.1; NC_021490.2.
DR   AlphaFoldDB; O83745; -.
DR   IntAct; O83745; 138.
DR   STRING; 243276.TP_0764; -.
DR   EnsemblBacteria; AAC65727; AAC65727; TP_0764.
DR   GeneID; 57879286; -.
DR   KEGG; tpa:TP_0764; -.
DR   PATRIC; fig|243276.9.peg.751; -.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_000445_92_1_12; -.
DR   OrthoDB; 9781505at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR   PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000811}.
FT   DOMAIN          134..329
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
SQ   SEQUENCE   391 AA;  43901 MW;  7A95EE5F35311FE2 CRC64;
     MNTYAIVDIP EETHFSDDVY LDDTFLVLTP AGLFDEALKS RLQEWDFTTV HTGGQLLSSE
     TTLECPLPAS GDPNAKGAPG SEALRAQRSR FHALKKQYNE FQMFVEHVFD QYRAKQSLNT
     RAVIDRAKML CELVKKHRQT LLRVLPTIPY REHYALETHA LRSTLYAVVI GLQLKMQPFK
     IIELATSCLL HEIGMARVIP KAYTTEGELD PKTQKAIFAH PIISYHILRD HSLPLPVCVG
     ALEHRERENG LGYPRRLVGE KISLYGKIIA VACSYEAATA PRSYKEMKNA AEGIVDLVRN
     ANTQYDAVIS RALLFALSFY PIGTHVHLSN GKIAQVVDVN PDDPRFPIVQ VHGEIHRNGK
     PIIHSTSADE IFITRALSVK EQRLILQEGG D
//