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O83738

- DEF_TREPA

UniProt

O83738 - DEF_TREPA

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Protein
Peptide deformylase
Gene
def, TP_0757
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron By similarity
Metal bindingi128 – 1281Iron By similarity
Active sitei129 – 1291 By similarity
Metal bindingi132 – 1321Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:TP_0757
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Peptide deformylaseUniRule annotation
PRO_0000082869Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TP_0961O839272EBI-1199001,EBI-1198947

Protein-protein interaction databases

IntActiO83738. 40 interactions.
MINTiMINT-6481412.
STRINGi243276.TP0757.

Structurei

3D structure databases

ProteinModelPortaliO83738.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiVEYLSPF.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

O83738-1 [UniParc]FASTAAdd to Basket

« Hide

MELKFLGEPC LTTVSEPVSE VDEQLRAFIS GMFRVMRGAG GVGLAAPQVG    50
RTVRVFVVDV EHHVRAFINP QITAASEEQS SYEEGCLSIP HIYERVLRPR 100
RVSVQYLDEN GKRCAVDADG ILARVIQHEY DHLDGILFLD RIDEKRRDDA 150
LRRYAALRGT IR 162
Length:162
Mass (Da):18,323
Last modified:November 1, 1998 - v1
Checksum:i15AEA6C940819CC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65724.1.
PIRiH71284.
RefSeqiNP_219194.1. NC_000919.1.
YP_008091586.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65724; AAC65724; TP_0757.
GeneIDi15852048.
2611341.
KEGGitpa:TP0757.
tpw:TPANIC_0757.
PATRICi20531603. VBITrePal57110_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65724.1 .
PIRi H71284.
RefSeqi NP_219194.1. NC_000919.1.
YP_008091586.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83738.
ModBasei Search...

Protein-protein interaction databases

IntActi O83738. 40 interactions.
MINTi MINT-6481412.
STRINGi 243276.TP0757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65724 ; AAC65724 ; TP_0757 .
GeneIDi 15852048.
2611341.
KEGGi tpa:TP0757.
tpw:TPANIC_0757.
PATRICi 20531603. VBITrePal57110_0801.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi VEYLSPF.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-803-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiDEF_TREPA
AccessioniPrimary (citable) accession number: O83738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi