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O83738

- DEF_TREPA

UniProt

O83738 - DEF_TREPA

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Protein

Peptide deformylase

Gene

def

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861IronBy similarity
Metal bindingi128 – 1281IronBy similarity
Active sitei129 – 1291By similarity
Metal bindingi132 – 1321IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:TP_0757
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Peptide deformylasePRO_0000082869Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TP_0961O839272EBI-1199001,EBI-1198947

Protein-protein interaction databases

IntActiO83738. 40 interactions.
MINTiMINT-6481412.
STRINGi243276.TP0757.

Structurei

3D structure databases

ProteinModelPortaliO83738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiVEYLSPF.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

O83738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELKFLGEPC LTTVSEPVSE VDEQLRAFIS GMFRVMRGAG GVGLAAPQVG
60 70 80 90 100
RTVRVFVVDV EHHVRAFINP QITAASEEQS SYEEGCLSIP HIYERVLRPR
110 120 130 140 150
RVSVQYLDEN GKRCAVDADG ILARVIQHEY DHLDGILFLD RIDEKRRDDA
160
LRRYAALRGT IR
Length:162
Mass (Da):18,323
Last modified:November 1, 1998 - v1
Checksum:i15AEA6C940819CC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65724.1.
PIRiH71284.
RefSeqiNP_219194.1. NC_000919.1.
YP_008091586.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65724; AAC65724; TP_0757.
GeneIDi15852048.
2611341.
KEGGitpa:TP0757.
tpw:TPANIC_0757.
PATRICi20531603. VBITrePal57110_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65724.1 .
PIRi H71284.
RefSeqi NP_219194.1. NC_000919.1.
YP_008091586.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83738. 40 interactions.
MINTi MINT-6481412.
STRINGi 243276.TP0757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65724 ; AAC65724 ; TP_0757 .
GeneIDi 15852048.
2611341.
KEGGi tpa:TP0757.
tpw:TPANIC_0757.
PATRICi 20531603. VBITrePal57110_0801.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi VEYLSPF.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-803-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiDEF_TREPA
AccessioniPrimary (citable) accession number: O83738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3