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O83737 (FMT_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase

EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:TP_0756
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_0000083077

Regions

Region116 – 1194Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
O83737 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 92DAEEE1ACE33D3A

FASTA31934,261
        10         20         30         40         50         60 
MVRVFFAGTP ECAVPSLRRV ACAHRVVGVL TNPPAAVGRS GKLVHSAVAR EFFRLKASGV 

        70         80         90        100        110        120 
LPESASLFVP GRLDRAFYDA VEALRPDVLV CFAYGKIFGP RFLALFPRGA INVHPSLLPR 

       130        140        150        160        170        180 
WRGSTPVPAA ILAGDCETGV TLQYIGEEMD AGDILAQSRV QLDGTETTGA LLSRLSLVAA 

       190        200        210        220        230        240 
DLVDDVLVGV ERHTLAPAAQ DHSQATFCGK LCREMGLADW SNPAVVLERK IRAFTPWPGL 

       250        260        270        280        290        300 
FTYKDGERIA ILQARSCESS FVPLAPVGTV LAADKNGVFV QTGDGVLSLL QLQRSGKKPL 

       310 
FWRDFLNGSP LLLTGRLGV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65723.1.
PIRG71284.
RefSeqNP_219193.1. NC_000919.1.
YP_008091585.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83737.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83737. 16 interactions.
STRING243276.TP0756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65723; AAC65723; TP_0756.
GeneID15852047.
2611340.
KEGGtpa:TP0756.
tpw:TPANIC_0756.
PATRIC20531601. VBITrePal57110_0800.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0223.
KOK00604.
OMASTMLMDV.
OrthoDBEOG6B09WV.
ProtClustDBCLSK218850.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-802-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFMT_TREPA
AccessionPrimary (citable) accession number: O83737
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families