O83737 (FMT_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionyl-tRNA formyltransferase
EC=2.1.2.9

Gene names

Name:	fmt
Ordered Locus Names:	TP_0756

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP MF_00182
Catalytic activity	10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H2O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP MF_00182
Sequence similarities	Belongs to the fmt family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	methionyl-tRNA formyltransferase activity Inferred from electronic annotation. Source: EC methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Methionyl-tRNA formyltransferase HAMAP MF_00182		PRO_0000083077
Regions
	Region	116 – 119	4	Tetrahydrofolate (THF) binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83737 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 92DAEEE1ACE33D3A	FASTA	319	34,261
	10 20 30 40 50 60 MVRVFFAGTP ECAVPSLRRV ACAHRVVGVL TNPPAAVGRS GKLVHSAVAR EFFRLKASGV 70 80 90 100 110 120 LPESASLFVP GRLDRAFYDA VEALRPDVLV CFAYGKIFGP RFLALFPRGA INVHPSLLPR 130 140 150 160 170 180 WRGSTPVPAA ILAGDCETGV TLQYIGEEMD AGDILAQSRV QLDGTETTGA LLSRLSLVAA 190 200 210 220 230 240 DLVDDVLVGV ERHTLAPAAQ DHSQATFCGK LCREMGLADW SNPAVVLERK IRAFTPWPGL 250 260 270 280 290 300 FTYKDGERIA ILQARSCESS FVPLAPVGTV LAADKNGVFV QTGDGVLSLL QLQRSGKKPL 310 FWRDFLNGSP LLLTGRLGV

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000520 Genomic DNA. Translation: AAC65723.1.
PIR	G71284.
RefSeq	NP_219193.1. NC_000919.1.
3D structure databases
ProteinModelPortal	O83737.
ModBase	Search...
Protein-protein interaction databases
IntAct	O83737. 16 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2611340.
GenomeReviews	Gene locus TP_0756 in contig AE000520_GR.
KEGG	tpa:TP0756.
NMPDR	fig|243276.1.peg.752.
PATRIC	20531601. VBITrePal57110_0800.
TIGR	TP_0756.
Phylogenomic databases
HOGENOM	HBG571560.
OMA	VENEKSH.
ProtClustDB	CLSK218850.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0756-MONOMER.
Family and domain databases
HAMAP	MF_00182. Formyl_trans. [Tree]
InterPro	IPR005794. Fmt. IPR005793. Formyl_trans_C. IPR002376. Formyl_transf_N. IPR011034. Formyl_transferase_C-like. IPR015518. Met_tRNA_Form_TA-like. [Graphical view]
Gene3D	G3DSA:3.10.25.10. Formyl_trans_C. 1 hit. G3DSA:3.40.50.170. Formyl_transf_N. 1 hit.
KO	K00604.
PANTHER	PTHR11138. Met_tRNA_Form_TA-like. 1 hit.
Pfam	PF02911. Formyl_trans_C. 1 hit. PF00551. Formyl_trans_N. 1 hit. [Graphical view]
SUPFAM	SSF50486. FMT_C_like. 1 hit. SSF53328. formyl_transf. 1 hit.
TIGRFAMs	TIGR00460. Fmt. 1 hit.
PROSITE	PS00373. GART. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FMT_TREPA

Accession

Primary (citable) accession number: O83737

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program