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Protein

GTPase Obg

Gene

obg

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175MagnesiumUniRule annotation1
Metal bindingi195MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 175GTPUniRule annotation8
Nucleotide bindingi193 – 197GTPUniRule annotation5
Nucleotide bindingi215 – 218GTPUniRule annotation4
Nucleotide bindingi282 – 285GTPUniRule annotation4
Nucleotide bindingi309 – 311GTPUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:TP_0742
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003863661 – 376GTPase ObgAdd BLAST376

Proteomic databases

PRIDEiO83724

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0742

Structurei

3D structure databases

ProteinModelPortaliO83724
SMRiO83724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 328OBG-type GUniRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R Bacteria
COG0536 LUCA
OMAiPHVGIVH

Family and domain databases

CDDicd01898 Obg, 1 hit
Gene3Di2.70.210.12, 1 hit
HAMAPiMF_01454 GTPase_Obg, 1 hit
InterProiView protein in InterPro
IPR031167 G_OBG
IPR035101 GTP-bd_Obg
IPR014100 GTP-bd_Obg/CgtA
IPR006169 GTP1_OBG_dom
IPR036726 GTP1_OBG_dom_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01018 GTP1_OBG, 1 hit
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF002401 GTP_bd_Obg/CgtA, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF82051 SSF82051, 1 hit
TIGRFAMsiTIGR02729 Obg_CgtA, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

O83724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFVDEVLI RVSSGRGGNG CVAFRREKYV PRGGPAGGDG GRGGDVVFQV
60 70 80 90 100
RRNMRTLVHL RYGRVFRAKN GQDGEGARRF GAKGHDCVIP LPPGCLLRDA
110 120 130 140 150
QTHEVLHDFG HAHEGCVTLL SGGRGGWGNY HFRGPVQQAP QRAHSGQPGQ
160 170 180 190 200
ERVVHVELRI VADVGFVGLP NAGKSSLLNF FTHARSRVAP YPFTTRIPYL
210 220 230 240 250
GVLRTGDGRD VILADVPGIL ERASQGVGLG LRFLKHLTRC AGLAFLIDLA
260 270 280 290 300
DERALHTYDL LCKELYAFSP VFETKARVLV GTKLDLPNAR ECLQQLRAQH
310 320 330 340 350
PSTEVCGVSV HNRWGLDELQ EAFVRLSDAG AGALRSPVWR NQAPSFMYAQ
360 370
LEDPVCQVRD DFGATVSLSR KRKVRG
Length:376
Mass (Da):41,145
Last modified:November 1, 1998 - v1
Checksum:iF6F91264FB46578B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA Translation: AAC65711.1
PIRiC71286
RefSeqiWP_010882187.1, NC_021490.2

Genome annotation databases

EnsemblBacteriaiAAC65711; AAC65711; TP_0742
GeneIDi34331938
KEGGitpa:TP_0742

Similar proteinsi

Entry informationi

Entry nameiOBG_TREPA
AccessioniPrimary (citable) accession number: O83724
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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