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Protein

GTPase Obg

Gene

obg

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175MagnesiumUniRule annotation1
Metal bindingi195MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 175GTPUniRule annotation8
Nucleotide bindingi193 – 197GTPUniRule annotation5
Nucleotide bindingi215 – 218GTPUniRule annotation4
Nucleotide bindingi282 – 285GTPUniRule annotation4
Nucleotide bindingi309 – 311GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:TP_0742
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003863661 – 376GTPase ObgAdd BLAST376

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0742.

Structurei

3D structure databases

ProteinModelPortaliO83724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 328OBG-type GUniRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
OMAiMNFASST.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFVDEVLI RVSSGRGGNG CVAFRREKYV PRGGPAGGDG GRGGDVVFQV
60 70 80 90 100
RRNMRTLVHL RYGRVFRAKN GQDGEGARRF GAKGHDCVIP LPPGCLLRDA
110 120 130 140 150
QTHEVLHDFG HAHEGCVTLL SGGRGGWGNY HFRGPVQQAP QRAHSGQPGQ
160 170 180 190 200
ERVVHVELRI VADVGFVGLP NAGKSSLLNF FTHARSRVAP YPFTTRIPYL
210 220 230 240 250
GVLRTGDGRD VILADVPGIL ERASQGVGLG LRFLKHLTRC AGLAFLIDLA
260 270 280 290 300
DERALHTYDL LCKELYAFSP VFETKARVLV GTKLDLPNAR ECLQQLRAQH
310 320 330 340 350
PSTEVCGVSV HNRWGLDELQ EAFVRLSDAG AGALRSPVWR NQAPSFMYAQ
360 370
LEDPVCQVRD DFGATVSLSR KRKVRG
Length:376
Mass (Da):41,145
Last modified:November 1, 1998 - v1
Checksum:iF6F91264FB46578B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65711.1.
PIRiC71286.
RefSeqiWP_010882187.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65711; AAC65711; TP_0742.
GeneIDi2611092.
KEGGitpa:TP_0742.
PATRICi20531575. VBITrePal57110_0787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65711.1.
PIRiC71286.
RefSeqiWP_010882187.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65711; AAC65711; TP_0742.
GeneIDi2611092.
KEGGitpa:TP_0742.
PATRICi20531575. VBITrePal57110_0787.

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
OMAiMNFASST.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOBG_TREPA
AccessioniPrimary (citable) accession number: O83724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.