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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

  1. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-type (EC:2.4.2.1)
Short name:
PNP
Gene namesi
Name:deoD
Ordered Locus Names:TP_0734
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Purine nucleoside phosphorylase DeoD-typePRO_0000063168Add
BLAST

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi243276.TP0734.

Structurei

3D structure databases

ProteinModelPortaliO83716.
SMRiO83716. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiCOG0813.
KOiK03784.
OMAiIRNDWPQ.
OrthoDBiEOG6BKJC5.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHLGAKGE DIAPRVLLPG DPLRARFVAE RFFHNAYCYN EVRGMLGFTG
60 70 80 90 100
TYKGVRVSVQ GTGMGLPSHS IYVTELFQDY GVQKAIRVGT AGGLQEEVAL
110 120 130 140 150
KSVVCALGAA TDSAINARRF SGMHFAPTAS WSLLRTAVSV ADEMGTGVQV
160 170 180 190 200
GNVISSDVFY DESGSWRLWA RYGVLAVEME TAELYTLAAK FRREALSILT
210 220 230
ISDHLVTGAV TSAQERERSF TQMIEIALEA IIQ
Length:233
Mass (Da):25,318
Last modified:October 31, 1998 - v1
Checksum:iD1A94487B7434A23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65702.1.
PIRiC71288.
RefSeqiNP_219171.1. NC_000919.1.
YP_008091563.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65702; AAC65702; TP_0734.
KEGGitpa:TP0734.
tpw:TPANIC_0734.
PATRICi20531559. VBITrePal57110_0779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65702.1.
PIRiC71288.
RefSeqiNP_219171.1. NC_000919.1.
YP_008091563.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83716.
SMRiO83716. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65702; AAC65702; TP_0734.
KEGGitpa:TP0734.
tpw:TPANIC_0734.
PATRICi20531559. VBITrePal57110_0779.

Phylogenomic databases

eggNOGiCOG0813.
KOiK03784.
OMAiIRNDWPQ.
OrthoDBiEOG6BKJC5.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-780-MONOMER.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01627. Pur_nucleosid_phosp.
InterProiIPR004402. DeoD-type.
IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR00107. deoD. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiDEOD_TREPA
AccessioniPrimary (citable) accession number: O83716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 31, 1998
Last modified: March 31, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.