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O83676 (DDL_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:TP_0670
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177898

Regions

Domain141 – 347207ATP-grasp
Nucleotide binding174 – 22956ATP By similarity

Sites

Metal binding3011Magnesium or manganese 1 By similarity
Metal binding3141Magnesium or manganese 1 By similarity
Metal binding3141Magnesium or manganese 2 By similarity
Metal binding3161Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O83676 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: FB5829335B6111A5

FASTA39642,728
        10         20         30         40         50         60 
MVHVTLLYGG RSAEHDVSVR SARFVARTLC LQHTVMLIGI TRRGVWYAQP ACALEQLCTG 

        70         80         90        100        110        120 
TVALSIQEDE KRRVCLVPGG GTAGAFVIAG MPCVTDVVFP VLHGSYGEDG TVQGLLEMLQ 

       130        140        150        160        170        180 
VPYVGCGVCA SALAMDKVKA KMLWQAAGLP VLPFVFFRKD AWRMHMQEFV AQLETRLGYP 

       190        200        210        220        230        240 
LFVKPAQAGS SVGASAVQTR APLIPAIEAA FQWDEVVLVE RYVRAREIEC ALSGNGPYTV 

       250        260        270        280        290        300 
HGAGEVIAQG AFYDYEEKYA DASVARVLVT APLETAQYEQ ITTLALRAYE ALGLTGLARV 

       310        320        330        340        350        360 
DFFLLETGEV YVNEVNTMPG FTSISLFPQI CQAAGVAPQD LMAQLLSCAR ERFAARAALS 

       370        380        390 
TDLHAHVCAP SVTAAHDPDA QGDDWDQRDS NPLPTA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC26568.1.
PIRA71296.
RefSeqNP_219107.1. NC_000919.1.
YP_008091503.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83676.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83676. 2 interactions.
STRING243276.TP0670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC26568; AAC26568; TP_0670.
GeneID15851962.
2611545.
KEGGtpa:TP0670.
tpw:TPANIC_0670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-713-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_TREPA
AccessionPrimary (citable) accession number: O83676
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways