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O83668

- ALF_TREPA

UniProt

O83668 - ALF_TREPA

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561Glyceraldehyde 3-phosphateBy similarity
    Active sitei93 – 931Proton donorBy similarity
    Metal bindingi94 – 941Zinc 1; catalyticBy similarity
    Metal bindingi115 – 1151Zinc 2By similarity
    Metal bindingi147 – 1471Zinc 2By similarity
    Metal bindingi191 – 1911Zinc 1; catalyticBy similarity
    Binding sitei192 – 1921Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi234 – 2341Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fructose 1,6-bisphosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-703-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Synonyms:fda
    Ordered Locus Names:TP_0662
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Fructose-bisphosphate aldolasePRO_0000178753Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiO83668. 4 interactions.
    STRINGi243276.TP0662.

    Structurei

    3D structure databases

    ProteinModelPortaliO83668.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni235 – 2373Dihydroxyacetone phosphate bindingBy similarity
    Regioni277 – 2804Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    KOiK01624.
    OMAiGKMKETY.
    OrthoDBiEOG6HXJ7B.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR011289. Fruc_bis_ald_class-2.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01859. fruc_bis_ald_. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83668-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSYKALGLV NTKDLFAKAV KGGYAIPAYN FNNLEQLQAI IQACVETRSP    50
    VILQVSSGAR KYANATLLRN MARGAVEYAH ELGVDIPIVL HLDHGDSLEL 100
    CIDCIESGFS SVMIDGSALP YDENVALSRK VCEYAHARAD YVTVEGELGV 150
    LAGVEDDVVA EKSHYTMPDE VEDFVKKTGV DSLAISIGTS HGRAKFTPEQ 200
    CTRNADGVLI PPPLRFDILA EIEKRIPGFP IVLHGASSVP VEYVREVERY 250
    GGNLPDSVGI PEEQLRKAAK SAVCKVNIDS DGRLAMTAAI RRVLTTKVDE 300
    FDPRKYLGPA RDELKKLYMH KNKEVLGSAG RA 332
    Length:332
    Mass (Da):36,189
    Last modified:November 1, 1998 - v1
    Checksum:iB6D8D56BF99B52EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65635.1.
    PIRiG71297.
    RefSeqiNP_219099.1. NC_000919.1.
    YP_008091495.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65635; AAC65635; TP_0662.
    GeneIDi15851952.
    2611197.
    KEGGitpa:TP0662.
    tpw:TPANIC_0662.
    PATRICi20531397. VBITrePal57110_0703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65635.1 .
    PIRi G71297.
    RefSeqi NP_219099.1. NC_000919.1.
    YP_008091495.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83668.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O83668. 4 interactions.
    STRINGi 243276.TP0662.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65635 ; AAC65635 ; TP_0662 .
    GeneIDi 15851952.
    2611197.
    KEGGi tpa:TP0662.
    tpw:TPANIC_0662.
    PATRICi 20531397. VBITrePal57110_0703.

    Phylogenomic databases

    eggNOGi COG0191.
    KOi K01624.
    OMAi GKMKETY.
    OrthoDBi EOG6HXJ7B.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci TPAL243276:GC1H-703-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR011289. Fruc_bis_ald_class-2.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01859. fruc_bis_ald_. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiALF_TREPA
    AccessioniPrimary (citable) accession number: O83668
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3