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O83668

- ALF_TREPA

UniProt

O83668 - ALF_TREPA

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Glyceraldehyde 3-phosphateBy similarity
Active sitei93 – 931Proton donorBy similarity
Metal bindingi94 – 941Zinc 1; catalyticBy similarity
Metal bindingi115 – 1151Zinc 2By similarity
Metal bindingi147 – 1471Zinc 2By similarity
Metal bindingi191 – 1911Zinc 1; catalyticBy similarity
Binding sitei192 – 1921Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi234 – 2341Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-703-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fda
Ordered Locus Names:TP_0662
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Fructose-bisphosphate aldolasePRO_0000178753Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO83668. 4 interactions.
STRINGi243276.TP0662.

Structurei

3D structure databases

ProteinModelPortaliO83668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 2373Dihydroxyacetone phosphate bindingBy similarity
Regioni277 – 2804Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiGKMKETY.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83668-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSYKALGLV NTKDLFAKAV KGGYAIPAYN FNNLEQLQAI IQACVETRSP
60 70 80 90 100
VILQVSSGAR KYANATLLRN MARGAVEYAH ELGVDIPIVL HLDHGDSLEL
110 120 130 140 150
CIDCIESGFS SVMIDGSALP YDENVALSRK VCEYAHARAD YVTVEGELGV
160 170 180 190 200
LAGVEDDVVA EKSHYTMPDE VEDFVKKTGV DSLAISIGTS HGRAKFTPEQ
210 220 230 240 250
CTRNADGVLI PPPLRFDILA EIEKRIPGFP IVLHGASSVP VEYVREVERY
260 270 280 290 300
GGNLPDSVGI PEEQLRKAAK SAVCKVNIDS DGRLAMTAAI RRVLTTKVDE
310 320 330
FDPRKYLGPA RDELKKLYMH KNKEVLGSAG RA
Length:332
Mass (Da):36,189
Last modified:November 1, 1998 - v1
Checksum:iB6D8D56BF99B52EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65635.1.
PIRiG71297.
RefSeqiNP_219099.1. NC_000919.1.
YP_008091495.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65635; AAC65635; TP_0662.
GeneIDi15851952.
2611197.
KEGGitpa:TP0662.
tpw:TPANIC_0662.
PATRICi20531397. VBITrePal57110_0703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65635.1 .
PIRi G71297.
RefSeqi NP_219099.1. NC_000919.1.
YP_008091495.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83668. 4 interactions.
STRINGi 243276.TP0662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65635 ; AAC65635 ; TP_0662 .
GeneIDi 15851952.
2611197.
KEGGi tpa:TP0662.
tpw:TPANIC_0662.
PATRICi 20531397. VBITrePal57110_0703.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi GKMKETY.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci TPAL243276:GC1H-703-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiALF_TREPA
AccessioniPrimary (citable) accession number: O83668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3