Reviewed,
UniProtKB/Swiss-Prot O83641 (MSRAB_TREPA)
Last modified
November 4, 2008.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peptide methionine sulfoxide reductase msrB/msrA Including the following 2 domains: 1- Recommended name: Peptide methionine sulfoxide reductase msrB EC=1.8.4.12 Alternative name(s): Peptide-methionine (R)-S-oxide reductase 2- Recommended name: Peptide methionine sulfoxide reductase msrA Short name=Protein-methionine-S-oxide reductase EC=1.8.4.11 Alternative name(s): Peptide-methionine (S)-S-oxide reductase Short name=Peptide Met(O) reductase | ||||||
| Gene names |
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| Organism | Treponema pallidum [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 160 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema |
Protein attributes
| Sequence length | 291 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. |
| Catalytic activity | Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin. Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin. |
| Sequence similarities | In the N-terminal section; belongs to the msrB Met sulfoxide reductase family. In the C-terminal section; belongs to the msrA Met sulfoxide reductase family. |
Ontologies
Keywords | |
|---|---|
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Multifunctional enzyme |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification processInferred from electronic annotation. Source: HAMAP |
| Molecular function | peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 291 | 291 | Peptide methionine sulfoxide reductase msrB/msrA | PRO_0000138525 | |||||
Regions | |||||||||
| Region | 1 – 124 | 124 | Peptide methionine sulfoxide reductase B | ||||||
| Region | 127 – 284 | 158 | Peptide methionine sulfoxide reductase A | ||||||
Sites | |||||||||
| Active site | 113 | 1 | By similarity | ||||||
| Active site | 135 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. Venter J.C.Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
Cross-references
Sequence databases | |
|---|---|
| AE000520 Genomic DNA. Translation: AAC65608.1. | |
| PIR | G71300. |
| RefSeq | NP_219071.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1L1D based on UniProtKB P14930. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2611495. |
| GenomeReviews | Gene locus TP_0633 in contig AE000520_GR. |
| KEGG | tpa:TP0633. |
| NMPDR | fig|243276.1.peg.630. |
| TIGR | TP_0633. |
Phylogenomic databases | |
| HOGENOM | O83641. |
Enzyme and pathway databases | |
| BioCyc | TPAL243276:TP_0633-MON. |
Family and domain databases | |
| HAMAP | MF_01400. Fused. [Tree] MF_01401. Fused. [Tree] |
| InterPro | IPR002569. MsrA. IPR002579. MsrB. [Graphical view] |
| Gene3D | G3DSA:3.30.1060.10. MsrA. 1 hit. |
| Pfam | PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view] |
| ProDom | PD004057. DUF25. 1 hit. PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MSRAB_TREPA | ||||||||
| Accession | Primary (citable) accession number: O83641 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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