Reviewed, UniProtKB/Swiss-Prot O83641 (MSRAB_TREPA)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB/msrA
Including the following 2 domains:
    1- Recommended name:
            Peptide methionine sulfoxide reductase msrB
              EC=1.8.4.12
        Alternative name(s):
            Peptide-methionine (R)-S-oxide reductase
    2- Recommended name:
            Peptide methionine sulfoxide reductase msrA
                Short name=Protein-methionine-S-oxide reductase
              EC=1.8.4.11
        Alternative name(s):
            Peptide-methionine (S)-S-oxide reductase
              Short name=Peptide Met(O) reductase

Gene names

Name:	msrAB
Synonyms:	msrA
Ordered Locus Names:	TP_0633

Organism

Treponema pallidum [Complete proteome] [HAMAP]

Taxonomic identifier

160 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin. Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
Sequence similarities	In the N-terminal section; belongs to the msrB Met sulfoxide reductase family. In the C-terminal section; belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Peptide methionine sulfoxide reductase msrB/msrA		PRO_0000138525
Regions
	Region	1 – 124	124	Peptide methionine sulfoxide reductase B
	Region	127 – 284	158	Peptide methionine sulfoxide reductase A
Sites
	Active site	113	1	By similarity
	Active site	135	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83641-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3FF46CC8D37E8C15	FASTA	291	32,802
	10 20 30 40 50 60 MLANLQHLSD IQYRVTQQSA TETPFKNEFW NSYQPGFYLD VVSGELLFLS EDKFDSGCGW 70 80 90 100 110 120 PSFSAPAYAR AVIEKEDRTH NMLRTEVRSR NANSHLGHVF KDGPPERGGL RYCINSAALR 130 140 150 160 170 180 FVAREEGTAL FAAGCFWSTE AYFRRVKGVL RVRVGYTGGT TKSPTYRNVC TGTTGHAEAV 190 200 210 220 230 240 EILFDPQVIS YEDLLKHFFR MHDPTSLNKQ GGDVGTQYRS AIFYLSGTQK QQAETLMGRY 250 260 270 280 290 AGAGKFTRPL VTTLEEARDF YPAEEYHQDY LTKNPGGYCH VSLHLASEPL E

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000520 Genomic DNA. Translation: AAC65608.1.
PIR	G71300.
RefSeq	NP_219071.1.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Genome annotation databases
GeneID	2611495.
GenomeReviews	Gene locus TP_0633 in contig AE000520_GR.
KEGG	tpa:TP0633.
NMPDR	fig|243276.1.peg.630.
TIGR	TP_0633.
Phylogenomic databases
HOGENOM	O83641.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0633-MON.
Family and domain databases
HAMAP	MF_01400. Fused. [Tree] MF_01401. Fused. [Tree]
InterPro	IPR002569. MsrA. IPR002579. MsrB. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRAB_TREPA

Accession

Primary (citable) accession number: O83641

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1998
Last modified:	November 4, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)