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O83641 (MSRAB_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrB/MsrA

Including the following 2 domains:

  1. Peptide methionine sulfoxide reductase MsrB
    EC=1.8.4.12
    Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase
  2. Peptide methionine sulfoxide reductase MsrA
    Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
    Short name=Peptide Met(O) reductase
Gene names
Name:msrAB
Synonyms:msrA
Ordered Locus Names:TP_0633
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema ›

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01400

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP-Rule MF_01400

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01400

Sequence similarities

In the N-terminal section; belongs to the MsrB Met sulfoxide reductase family.

In the C-terminal section; belongs to the MsrA Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Peptide methionine sulfoxide reductase MsrB/MsrA HAMAP-Rule MF_01400
PRO_0000138525

Regions

Region1 – 124124Peptide methionine sulfoxide reductase B HAMAP-Rule MF_01400
Region127 – 284158Peptide methionine sulfoxide reductase A HAMAP-Rule MF_01400

Sites

Active site1131 By similarity
Active site1351 By similarity

Sequences

Sequence LengthMass (Da)Tools
O83641 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 3FF46CC8D37E8C15

FASTA29132,802
        10         20         30         40         50         60 
MLANLQHLSD IQYRVTQQSA TETPFKNEFW NSYQPGFYLD VVSGELLFLS EDKFDSGCGW 

        70         80         90        100        110        120 
PSFSAPAYAR AVIEKEDRTH NMLRTEVRSR NANSHLGHVF KDGPPERGGL RYCINSAALR 

       130        140        150        160        170        180 
FVAREEGTAL FAAGCFWSTE AYFRRVKGVL RVRVGYTGGT TKSPTYRNVC TGTTGHAEAV 

       190        200        210        220        230        240 
EILFDPQVIS YEDLLKHFFR MHDPTSLNKQ GGDVGTQYRS AIFYLSGTQK QQAETLMGRY 

       250        260        270        280        290 
AGAGKFTRPL VTTLEEARDF YPAEEYHQDY LTKNPGGYCH VSLHLASEPL E

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000520 Genomic DNA. Translation: AAC65608.1.
PIRG71300.
RefSeqNP_219071.1. NC_000919.1.

3D structure databases

ProteinModelPortalO83641.
SMRO83641. Positions 6-127.
ModBaseSearch...

Protein-protein interaction databases

STRING243276.TP0633.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65608; AAC65608; TP_0633.
GeneID2611495.
KEGGtpa:TP0633.
PATRIC20531339. VBITrePal57110_0677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0229.
KOK12267.
OMANLRHCVN.
ProtClustDBPRK05550.

Family and domain databases

Gene3D2.170.150.20. 1 hit.
3.30.1060.10. 1 hit.
HAMAPMF_01400. MsrB. Fused.
MF_01401. MsrA. Fused.
InterProIPR002569. Met_Sox_Rdtase_MsrA.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PfamPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
SSF51316. Mss4_like. 1 hit.
TIGRFAMsTIGR00401. msrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRAB_TREPA
AccessionPrimary (citable) accession number: O83641
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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