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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137L-tryptophanUniRule annotation1
Binding sitei187ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi149 – 151ATPUniRule annotation3
Nucleotide bindingi195 – 199ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Synonyms:trsA
Ordered Locus Names:TP_0632
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367011 – 337Tryptophan--tRNA ligaseAdd BLAST337

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiO83640, 2 interactors
STRINGi243276.TP0632

Structurei

3D structure databases

ProteinModelPortaliO83640
SMRiO83640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi195 – 199"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

O83640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVLTGDRP TGRLHLGHYA GSLGTRLRIQ SEHECFFIIA DLHTLTTRHG
60 70 80 90 100
RAQLAELPAL VRELVLDYLA CGIDAQRAVI YLQSAVPEVT ELAFIFANLV
110 120 130 140 150
TVPRLQRIPS LKEMAQAANL SELPFGLLGY PVLQAADILL ARAHLVPVGK
160 170 180 190 200
DNESHVELTR EVAKRFNRLY GEVFPLPRAL LSDCATLVGT DGQAKMSKSL
210 220 230 240 250
GNAIFLSDDE ETVRRKVRAM YTDPARTRAD IPGRVEGNPV FAYHDAFNPN
260 270 280 290 300
TDEVAHFKER YRAGRVGDTE VKDALARALN TFLEPIRARR AQLEQQPAYL
310 320 330
ARVLEEGCAR MRAEARKTMQ RVKEAMGLSA RPLVHLP
Length:337
Mass (Da):37,562
Last modified:November 1, 1998 - v1
Checksum:i75CE7018C14A166D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA Translation: AAC65607.1
PIRiF71300
RefSeqiWP_010882078.1, NC_021490.2

Genome annotation databases

EnsemblBacteriaiAAC65607; AAC65607; TP_0632
GeneIDi34331625
KEGGitpa:TP_0632

Similar proteinsi

Entry informationi

Entry nameiSYW_TREPA
AccessioniPrimary (citable) accession number: O83640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health