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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei198 – 1981ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Synonyms:trsA
Ordered Locus Names:TP_0632
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Tryptophan--tRNA ligasePRO_0000136701Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO83640. 2 interactions.
STRINGi243276.TP0632.

Structurei

3D structure databases

ProteinModelPortaliO83640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi10 – 189"HIGH" region
Motifi195 – 1995"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C31. Bacteria.
COG0180. LUCA.
KOiK01867.
OMAiFSMITPL.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVLTGDRP TGRLHLGHYA GSLGTRLRIQ SEHECFFIIA DLHTLTTRHG
60 70 80 90 100
RAQLAELPAL VRELVLDYLA CGIDAQRAVI YLQSAVPEVT ELAFIFANLV
110 120 130 140 150
TVPRLQRIPS LKEMAQAANL SELPFGLLGY PVLQAADILL ARAHLVPVGK
160 170 180 190 200
DNESHVELTR EVAKRFNRLY GEVFPLPRAL LSDCATLVGT DGQAKMSKSL
210 220 230 240 250
GNAIFLSDDE ETVRRKVRAM YTDPARTRAD IPGRVEGNPV FAYHDAFNPN
260 270 280 290 300
TDEVAHFKER YRAGRVGDTE VKDALARALN TFLEPIRARR AQLEQQPAYL
310 320 330
ARVLEEGCAR MRAEARKTMQ RVKEAMGLSA RPLVHLP
Length:337
Mass (Da):37,562
Last modified:November 1, 1998 - v1
Checksum:i75CE7018C14A166D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65607.1.
PIRiF71300.
RefSeqiWP_010882078.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65607; AAC65607; TP_0632.
GeneIDi2611479.
KEGGitpa:TP_0632.
PATRICi20531337. VBITrePal57110_0676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65607.1.
PIRiF71300.
RefSeqiWP_010882078.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO83640. 2 interactions.
STRINGi243276.TP0632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65607; AAC65607; TP_0632.
GeneIDi2611479.
KEGGitpa:TP_0632.
PATRICi20531337. VBITrePal57110_0676.

Phylogenomic databases

eggNOGiENOG4105C31. Bacteria.
COG0180. LUCA.
KOiK01867.
OMAiFSMITPL.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-671-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYW_TREPA
AccessioniPrimary (citable) accession number: O83640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.