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O83595 (SYL_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:TP_0586
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length878 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 878878Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152109

Regions

Motif43 – 5412"HIGH" region HAMAP-Rule MF_00049
Motif634 – 6385"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O83595 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: DCD74E2DC3652B74

FASTA87898,991
        10         20         30         40         50         60 
MGYPFRALEK KWQAYWRDKR VFCVSEDERF PPERRAYVLD MFPYPSAQGL HVGHPEGYTA 

        70         80         90        100        110        120 
TDIYCRYLRM GGYNVLHPMG FDAFGLPAEN FALKTGTHPR VSTSANCDTF RRQIQSFGFS 

       130        140        150        160        170        180 
YDWEREISTA DPEYYRWTQW LFLKLYEKGL AYEATAPINW CPSCKTGLAN EEVRDACCER 

       190        200        210        220        230        240 
CGAEVTRRGV RQWMVRITAY AERLLSDLDE LDWPESVKQM QRNWIGKSCG AEIDFPVDAP 

       250        260        270        280        290        300 
ACSVHDKLPQ TIRVYTTRAD TLFGVTYLVL APEHEAVTAL TTHAQRAAVQ AYVQRAAKKN 

       310        320        330        340        350        360 
DLERTDLAKE KTGVFTGAYV RNPINDMRIP VWVGDYVLVS YGTGAVMAVP AHDQRDWDFA 

       370        380        390        400        410        420 
TRFGLPKLTV VSADYTATVP NSNSPQGAVL QRCVSDEGFV VNSGAFNGLA SADARERIVA 

       430        440        450        460        470        480 
HLEMRGAGAR RVTYRLRDWV FSRQRYWGEP IPLVHCPSCG VVPLPESALP LLLPETADFT 

       490        500        510        520        530        540 
PTEDGQGPLA RARTWLRVPC PQCASDAVRE TNTMPQWAGS CWYYLRYMDP RNKTAFCAPE 

       550        560        570        580        590        600 
KERYWAPVAL YVGGAEHAVL HLLYARFWHK VLYDLGLVST KEPFARLVNQ GMITSYAYRR 

       610        620        630        640        650        660 
KNGALVPHDE VHTNAQGTYV HARTGEKLEC VVAKMSKALK NVVNPDDMIA AYGADACRVY 

       670        680        690        700        710        720 
EMFMGPLEAS KPWNTQGLVG VFRFLEKIWV LAGRVAAANG IPQDSRAEPP GDLHAQKKSC 

       730        740        750        760        770        780 
SMYALETLLH RTIQKVTDDT SALSFNTAIS QMMIFVNEAT RVARRMPLPS KMWEMFVKIL 

       790        800        810        820        830        840 
SPYAPHLAEE LWEMCGHTHT IAYEPWPQVD PARVAPHVCS VVVQVNGKVR DTFSVAPNAP 

       850        860        870 
NEELEQKARE TAGARKFLGT QQPKRVVIVP NKLVNFVL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65562.1.
PIRC71305.
RefSeqNP_219024.1. NC_000919.1.
YP_008091426.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83595.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83595. 24 interactions.
MINTMINT-6479611.
STRING243276.TP0586.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65562; AAC65562; TP_0586.
GeneID15851875.
2611793.
KEGGtpa:TP0586.
tpw:TPANIC_0586.
PATRIC20531227. VBITrePal57110_0626.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-620-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_TREPA
AccessionPrimary (citable) accession number: O83595
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries