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O83578 (ALKH_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative KHG/KDPG aldolase

Including the following 2 domains:

  1. 4-hydroxy-2-oxoglutarate aldolase
    EC=4.1.3.16
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name=KHG-aldolase
  2. 2-dehydro-3-deoxy-phosphogluconate aldolase
    EC=4.1.2.14
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name=KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
Gene names
Name:eda
Ordered Locus Names:TP_0568
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D-gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2.

Carbohydrate metabolism; glyoxylate and dicarboxylate metabolism.

Subunit structure

Homotrimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the KHG/KDPG aldolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydro-3-deoxy-phosphogluconate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

4-hydroxy-2-oxoglutarate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Putative KHG/KDPG aldolase
PRO_0000201043

Sites

Active site411 By similarity
Active site451 By similarity
Active site1291Schiff-base intermediate with KHG or pyruvate By similarity

Sequences

Sequence LengthMass (Da)Tools
O83578 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7DC3408B01C244E7

FASTA21022,074
        10         20         30         40         50         60 
MITIFEALER VRVIPVVTLE RVEDAVPLAR ALITGGIRCM EVTFRTLVAA EAIAAIRQEC 

        70         80         90        100        110        120 
ADVLLGAGTV LTVEQAQQAQ AAGAQFVVSP GFNPRVVAHC LGHGVPIIPG IASATEIERA 

       130        140        150        160        170        180 
LEFGISVVKF FPAELLGGTA MMSALARPYT AVRFVPTGGI HLNNLAEYVA HPRVLACGGS 

       190        200        210 
WMVPAQSIAA GDFSQVTALS QQTLQIVGVM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65542.1.
PIRF71308.
RefSeqNP_219007.1. NC_000919.1.
YP_008091410.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83578.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243276.TP0568.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65542; AAC65542; TP_0568.
GeneID15851859.
2611476.
KEGGtpa:TP0568.
tpw:TPANIC_0568.
PATRIC20531189. VBITrePal57110_0607.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0800.
KOK01625.
OMAKFFPAEY.
OrthoDBEOG67DPKT.
ProtClustDBCLSK2300246.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-602-MONOMER.
UniPathwayUPA00227.
UPA00856; UER00829.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01182. eda. 1 hit.
PROSITEPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALKH_TREPA
AccessionPrimary (citable) accession number: O83578
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: January 22, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways