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Protein

Putative KHG/KDPG aldolase

Gene

eda

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411PROSITE-ProRule annotation
Active sitei45 – 451PROSITE-ProRule annotation
Active sitei129 – 1291Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-602-MONOMER.
UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Ordered Locus Names:TP_0568
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Putative KHG/KDPG aldolasePRO_0000201043Add
BLAST

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi243276.TP0568.

Structurei

3D structure databases

ProteinModelPortaliO83578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

eggNOGiCOG0800.
KOiK01625.
OMAiMALPNVM.
OrthoDBiEOG67DPKT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83578-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITIFEALER VRVIPVVTLE RVEDAVPLAR ALITGGIRCM EVTFRTLVAA
60 70 80 90 100
EAIAAIRQEC ADVLLGAGTV LTVEQAQQAQ AAGAQFVVSP GFNPRVVAHC
110 120 130 140 150
LGHGVPIIPG IASATEIERA LEFGISVVKF FPAELLGGTA MMSALARPYT
160 170 180 190 200
AVRFVPTGGI HLNNLAEYVA HPRVLACGGS WMVPAQSIAA GDFSQVTALS
210
QQTLQIVGVM
Length:210
Mass (Da):22,074
Last modified:November 1, 1998 - v1
Checksum:i7DC3408B01C244E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65542.1.
PIRiF71308.
RefSeqiNP_219007.1. NC_000919.1.
YP_008091410.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65542; AAC65542; TP_0568.
GeneIDi15851859.
2611476.
KEGGitpa:TP0568.
tpw:TPANIC_0568.
PATRICi20531189. VBITrePal57110_0607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65542.1.
PIRiF71308.
RefSeqiNP_219007.1. NC_000919.1.
YP_008091410.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65542; AAC65542; TP_0568.
GeneIDi15851859.
2611476.
KEGGitpa:TP0568.
tpw:TPANIC_0568.
PATRICi20531189. VBITrePal57110_0607.

Phylogenomic databases

eggNOGiCOG0800.
KOiK01625.
OMAiMALPNVM.
OrthoDBiEOG67DPKT.

Enzyme and pathway databases

UniPathwayiUPA00227.
UPA00856; UER00829.
BioCyciTPAL243276:GC1H-602-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiALKH_TREPA
AccessioniPrimary (citable) accession number: O83578
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.