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O83578

- ALKH_TREPA

UniProt

O83578 - ALKH_TREPA

Protein

Putative KHG/KDPG aldolase

Gene

eda

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
    2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411PROSITE-ProRule annotation
    Active sitei45 – 451PROSITE-ProRule annotation
    Active sitei129 – 1291Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
    2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-602-MONOMER.
    UniPathwayiUPA00227.
    UPA00856; UER00829.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative KHG/KDPG aldolase
    Including the following 2 domains:
    4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name:
    KHG-aldolase
    2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name:
    KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
    Gene namesi
    Name:eda
    Ordered Locus Names:TP_0568
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Putative KHG/KDPG aldolasePRO_0000201043Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi243276.TP0568.

    Structurei

    3D structure databases

    ProteinModelPortaliO83578.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KHG/KDPG aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG0800.
    KOiK01625.
    OMAiWIANGEW.
    OrthoDBiEOG67DPKT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view]
    PfamiPF01081. Aldolase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01182. eda. 1 hit.
    PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83578-1 [UniParc]FASTAAdd to Basket

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    MITIFEALER VRVIPVVTLE RVEDAVPLAR ALITGGIRCM EVTFRTLVAA    50
    EAIAAIRQEC ADVLLGAGTV LTVEQAQQAQ AAGAQFVVSP GFNPRVVAHC 100
    LGHGVPIIPG IASATEIERA LEFGISVVKF FPAELLGGTA MMSALARPYT 150
    AVRFVPTGGI HLNNLAEYVA HPRVLACGGS WMVPAQSIAA GDFSQVTALS 200
    QQTLQIVGVM 210
    Length:210
    Mass (Da):22,074
    Last modified:November 1, 1998 - v1
    Checksum:i7DC3408B01C244E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65542.1.
    PIRiF71308.
    RefSeqiNP_219007.1. NC_000919.1.
    YP_008091410.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65542; AAC65542; TP_0568.
    GeneIDi15851859.
    2611476.
    KEGGitpa:TP0568.
    tpw:TPANIC_0568.
    PATRICi20531189. VBITrePal57110_0607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65542.1 .
    PIRi F71308.
    RefSeqi NP_219007.1. NC_000919.1.
    YP_008091410.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83578.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243276.TP0568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65542 ; AAC65542 ; TP_0568 .
    GeneIDi 15851859.
    2611476.
    KEGGi tpa:TP0568.
    tpw:TPANIC_0568.
    PATRICi 20531189. VBITrePal57110_0607.

    Phylogenomic databases

    eggNOGi COG0800.
    KOi K01625.
    OMAi WIANGEW.
    OrthoDBi EOG67DPKT.

    Enzyme and pathway databases

    UniPathwayi UPA00227 .
    UPA00856 ; UER00829 .
    BioCyci TPAL243276:GC1H-602-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view ]
    Pfami PF01081. Aldolase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01182. eda. 1 hit.
    PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiALKH_TREPA
    AccessioniPrimary (citable) accession number: O83578
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3