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O83549 (PGK_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:TP_0538
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146030

Regions

Nucleotide binding376 – 3794ATP By similarity
Region21 – 233Substrate binding By similarity
Region60 – 634Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1371Substrate By similarity
Binding site1741Substrate By similarity
Binding site2251ATP By similarity
Binding site3161ATP; via carbonyl oxygen By similarity
Binding site3471ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O83549 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7A8C5CACA906342D

FASTA41944,944
        10         20         30         40         50         60 
MMLRTCKDVT MRGERVVVRV DFNVPMRDGM VQDDTRVTAA VPTLRYIIEQ GPRHVVLISH 

        70         80         90        100        110        120 
LGDPTRDADK AEGNAKKDGC PFDRHAFING KHRLKPVADC LAKKLGVPVH FAPSCVGQRE 

       130        140        150        160        170        180 
FIEGLPDGSV VLLENVRFHP EETSGDAKVQ EQFARELAQY GDIFVNDAFG TAHREHASTV 

       190        200        210        220        230        240 
VLPRLMRRRV AGLLIEREVR YLEPMVCNPK VPMVAVVGGA KVSSKIAVLE SLLRTSTALI 

       250        260        270        280        290        300 
IGGGMAYTFL KAQGVGVGTS LVEDDFIDTA RMLLQKAQSG GVSVVLPVDH VCASTFCADA 

       310        320        330        340        350        360 
QPVAVDDVHI PMHLMGMDVG PRTLEQYRAH LKGVSSVLWN GPVGVFEFDA FAHGTRVLAQ 

       370        380        390        400        410 
LIAEATDAGA TSVVGGGDSI AAVSKFGLAS RMSHVSTGGG ASLKLFEGKV LPGISCLET 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65523.1.
PIRG71311.
RefSeqNP_218977.1. NC_000919.1.
YP_008091380.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83549. 1 interaction.
STRING243276.TP0538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65523; AAC65523; TP_0538.
GeneID15851827.
2611673.
KEGGtpa:TP0538.
tpw:TPANIC_0538.
PATRIC20531123. VBITrePal57110_0576.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMADMIFDIG.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-570-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_TREPA
AccessionPrimary (citable) accession number: O83549
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways