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O83549

- PGK_TREPA

UniProt

O83549 - PGK_TREPA

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei174 – 1741SubstrateBy similarity
Binding sitei225 – 2251ATPBy similarity
Binding sitei316 – 3161ATP; via carbonyl oxygenBy similarity
Binding sitei347 – 3471ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi376 – 3794ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-570-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:TP_0538
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Phosphoglycerate kinasePRO_0000146030Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiO83549. 1 interaction.
STRINGi243276.TP0538.

Structurei

3D structure databases

ProteinModelPortaliO83549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni60 – 634Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiVWNISAQ.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83549-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLRTCKDVT MRGERVVVRV DFNVPMRDGM VQDDTRVTAA VPTLRYIIEQ
60 70 80 90 100
GPRHVVLISH LGDPTRDADK AEGNAKKDGC PFDRHAFING KHRLKPVADC
110 120 130 140 150
LAKKLGVPVH FAPSCVGQRE FIEGLPDGSV VLLENVRFHP EETSGDAKVQ
160 170 180 190 200
EQFARELAQY GDIFVNDAFG TAHREHASTV VLPRLMRRRV AGLLIEREVR
210 220 230 240 250
YLEPMVCNPK VPMVAVVGGA KVSSKIAVLE SLLRTSTALI IGGGMAYTFL
260 270 280 290 300
KAQGVGVGTS LVEDDFIDTA RMLLQKAQSG GVSVVLPVDH VCASTFCADA
310 320 330 340 350
QPVAVDDVHI PMHLMGMDVG PRTLEQYRAH LKGVSSVLWN GPVGVFEFDA
360 370 380 390 400
FAHGTRVLAQ LIAEATDAGA TSVVGGGDSI AAVSKFGLAS RMSHVSTGGG
410
ASLKLFEGKV LPGISCLET
Length:419
Mass (Da):44,944
Last modified:November 1, 1998 - v1
Checksum:i7A8C5CACA906342D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65523.1.
PIRiG71311.
RefSeqiNP_218977.1. NC_000919.1.
YP_008091380.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65523; AAC65523; TP_0538.
GeneIDi15851827.
2611673.
KEGGitpa:TP0538.
tpw:TPANIC_0538.
PATRICi20531123. VBITrePal57110_0576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65523.1 .
PIRi G71311.
RefSeqi NP_218977.1. NC_000919.1.
YP_008091380.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83549. 1 interaction.
STRINGi 243276.TP0538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65523 ; AAC65523 ; TP_0538 .
GeneIDi 15851827.
2611673.
KEGGi tpa:TP0538.
tpw:TPANIC_0538.
PATRICi 20531123. VBITrePal57110_0576.

Phylogenomic databases

eggNOGi COG0126.
KOi K00927.
OMAi VWNISAQ.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci TPAL243276:GC1H-570-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiPGK_TREPA
AccessioniPrimary (citable) accession number: O83549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3