O83544 (VATI2_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase subunit I 2

Alternative name(s):
V-ATPase subunit I 2

Gene names

Name:	atpI2
Ordered Locus Names:	TP_0533

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the V-ATPase 116 kDa subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting two-sector ATPase complex, proton-transporting domain Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	V-type ATP synthase subunit I 2		PRO_0000119243
Regions
	Transmembrane	254 – 274	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Transmembrane	351 – 371	21	Helical; Potential
	Transmembrane	424 – 444	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O83544 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E96C1E95A9C1BD33	FASTA	454	50,847
	10 20 30 40 50 60 MFRSQRMKFL ELVVLERDVD RVLEYLGKTA LVHLRLSAAA RGSSSHCAQS KEYVGRLEEA 70 80 90 100 110 120 CKYLGVSGEC AFSPGDSLPT EEDYTLAQQI LAEVDALHAR EREGDAPSVP RGKSSVAHDS 130 140 150 160 170 180 ANEEQFQGEK CALGSMRGPA LCALLRRFAL QERVHRTRDA LESTRHTYRI AGWLPAHEAK 190 200 210 220 230 240 DLVAGLDNVT TGRMAVRLFE PQELSFIRDG SEHVPVCYQH GRFVRSYERM VSSYGCPPYG 250 260 270 280 290 300 LVDPTPFVAF SYALLFGIMF GDLGQGLLFF VLGLLLRTRR VRALNRWAHL DYVFLSVGFS 310 320 330 340 350 360 SMVMGFLTGE FFAHGTLLAP LIRSVTALCG GVPRDHILHL MPSHGSLHTL MAFFGFTLFL 370 380 390 400 410 420 GFVINSLGLI INIVNQVRLR HALQQCVQKR ECADSSFFGT WLPLQCAYHF LEFHSGSLMR 430 440 450 LQWACLSWVF FVKSFWSVCA SVCVRGFLKV LACI

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000520 Genomic DNA. Translation: AAC65519.1.
PIR	F71313.
RefSeq	NP_218972.1. NC_000919.1.
3D structure databases
ProteinModelPortal	O83544.
ModBase	Search...
Protein-protein interaction databases
IntAct	O83544. 3 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2610824.
GenomeReviews	Gene locus TP_0533 in contig AE000520_GR.
KEGG	tpa:TP0533.
NMPDR	fig|243276.1.peg.531.
PATRIC	20531109. VBITrePal57110_0569.
TIGR	TP_0533.
Phylogenomic databases
HOGENOM	HBG250989.
ProtClustDB	CLSK2300238.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0533-MONOMER.
Family and domain databases
InterPro	IPR002490. ATPase_V0/A0-cplx_116kDa_su. [Graphical view]
KO	K02123.
Pfam	PF01496. V_ATPase_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATI2_TREPA

Accession

Primary (citable) accession number: O83544

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program