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O83536 (LON_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lon protease
EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La
Gene names
Name:lon
Ordered Locus Names:TP_0524
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length881 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.

Catalytic activity

Hydrolysis of proteins in presence of ATP.

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm By similarity.

Induction

By heat shock By similarity.

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 881881Lon protease
PRO_0000076146

Regions

Domain94 – 285192Lon
Nucleotide binding440 – 4478ATP By similarity

Sites

Active site7671 By similarity
Active site8101 By similarity

Sequences

Sequence LengthMass (Da)Tools
O83536 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7D1905CD4920B504

FASTA88197,728
        10         20         30         40         50         60 
MAKNTDIEHD AHEPAGHGDV RESAVENPSA SAVSDGEERA TFAPEVAPQT DTESAQGAAQ 

        70         80         90        100        110        120 
ESEPEVQRAG EAEKGVPEKA KAVVPLDELL PQKVHLIPLT GRPIYPGIFT PLLISDEDDV 

       130        140        150        160        170        180 
RSVESAYSDS GFIGLCLVKT DTQNPTISDL YEVGSVARIV KKINLPDGGL NVFISTQKRF 

       190        200        210        220        230        240 
RIRKHVHHSK PIVAAVQYLS DLIEGDPLEI KALVRGLIGE MKELSENNPL FSEEMRLNMI 

       250        260        270        280        290        300 
NIDHPGKIAD FIASILNISK EEQQRTLEIL DVRKRMEEVF VYIKKEKDLL EIQRKIQNDL 

       310        320        330        340        350        360 
NSRVEKNQRE YFLREELRSI KEELGLTTDP KERDQRKFRA LIDSFHFEGE VKEAVESELE 

       370        380        390        400        410        420 
KLSLTDPNSP EYSVGRTYLE TVLSLPWHAP EKEEYDLKKA QKLLDEDHYG LENVKERIVE 

       430        440        450        460        470        480 
YLAVRKLRAD TKGSIILLVG PPGVGKTSVG KSIARAIHKP FFRFSVGGIS DEAEIKGHRR 

       490        500        510        520        530        540 
TYIGALPGKV LQGLKIVKTK APVFMIDEVD KIGSGARGDP AGALLEVLDP EQNTTFRDHY 

       550        560        570        580        590        600 
LDLPFDLSHI VFVLTANSTD PIPRPLLDRA EIIRLSGYID TEKVEIAKRH LVPKTLEKNG 

       610        620        630        640        650        660 
LKRACVSYRK EVLLHLVHSY ARESGVRGLE KSLDKLHRKL ATEIVLGKRS FDDKCLMDEA 

       670        680        690        700        710        720 
LIGTFLGKPV FRDDMLKDAN KVGTAVGLAW TGMGGDTLLV EAITIPGKAS FKLTGQMGAV 

       730        740        750        760        770        780 
MKESASIALS WLRRYSAQQR IASPNWFEKR AIHLHIPEGA TPKDGPSAGI TMTTTLFSLL 

       790        800        810        820        830        840 
TQQKVKPRLA MTGELSLTGQ VLPIGGLKEK TIAARRGGIK EIIMPKANVR DLDEIPEHVK 

       850        860        870        880 
KGMVFHLVES MEEVLSLAFP KGKRVRAGTA AQSASPETLT G

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000520 Genomic DNA. Translation: AAC65510.1.
PIRB71316.
RefSeqNP_218964.1. NC_000919.1.

3D structure databases

ProteinModelPortalO83536.
SMRO83536. Positions 681-861.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2610752.
GenomeReviewsGene locus TP_0524 in contig AE000520_GR.
KEGGtpa:TP0524.
NMPDRfig|243276.1.peg.523.
PATRIC20531087. VBITrePal57110_0558.
TIGRTP_0524.

Phylogenomic databases

HOGENOMHBG566281.
OMANIKNGIN.
ProtClustDBCLSK2459990.

Enzyme and pathway databases

BioCycTPAL243276:TP_0524-MONOMER.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR008269. Pept_S16_C.
IPR004815. Pept_S16_lon.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
KOK01338.
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF88697. PUA-like. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00763. Lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_TREPA
AccessionPrimary (citable) accession number: O83536
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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