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Protein

Lon protease

Gene

lon

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei767 – 7671UniRule annotation
Active sitei810 – 8101UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi440 – 4478ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:TP_0524
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Lon proteasePRO_0000076146Add
BLAST

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0524.

Structurei

3D structure databases

ProteinModelPortaliO83536.
SMRiO83536. Positions 681-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 285192Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini679 – 861183Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.
OMAiVGAYKGE.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNTDIEHD AHEPAGHGDV RESAVENPSA SAVSDGEERA TFAPEVAPQT
60 70 80 90 100
DTESAQGAAQ ESEPEVQRAG EAEKGVPEKA KAVVPLDELL PQKVHLIPLT
110 120 130 140 150
GRPIYPGIFT PLLISDEDDV RSVESAYSDS GFIGLCLVKT DTQNPTISDL
160 170 180 190 200
YEVGSVARIV KKINLPDGGL NVFISTQKRF RIRKHVHHSK PIVAAVQYLS
210 220 230 240 250
DLIEGDPLEI KALVRGLIGE MKELSENNPL FSEEMRLNMI NIDHPGKIAD
260 270 280 290 300
FIASILNISK EEQQRTLEIL DVRKRMEEVF VYIKKEKDLL EIQRKIQNDL
310 320 330 340 350
NSRVEKNQRE YFLREELRSI KEELGLTTDP KERDQRKFRA LIDSFHFEGE
360 370 380 390 400
VKEAVESELE KLSLTDPNSP EYSVGRTYLE TVLSLPWHAP EKEEYDLKKA
410 420 430 440 450
QKLLDEDHYG LENVKERIVE YLAVRKLRAD TKGSIILLVG PPGVGKTSVG
460 470 480 490 500
KSIARAIHKP FFRFSVGGIS DEAEIKGHRR TYIGALPGKV LQGLKIVKTK
510 520 530 540 550
APVFMIDEVD KIGSGARGDP AGALLEVLDP EQNTTFRDHY LDLPFDLSHI
560 570 580 590 600
VFVLTANSTD PIPRPLLDRA EIIRLSGYID TEKVEIAKRH LVPKTLEKNG
610 620 630 640 650
LKRACVSYRK EVLLHLVHSY ARESGVRGLE KSLDKLHRKL ATEIVLGKRS
660 670 680 690 700
FDDKCLMDEA LIGTFLGKPV FRDDMLKDAN KVGTAVGLAW TGMGGDTLLV
710 720 730 740 750
EAITIPGKAS FKLTGQMGAV MKESASIALS WLRRYSAQQR IASPNWFEKR
760 770 780 790 800
AIHLHIPEGA TPKDGPSAGI TMTTTLFSLL TQQKVKPRLA MTGELSLTGQ
810 820 830 840 850
VLPIGGLKEK TIAARRGGIK EIIMPKANVR DLDEIPEHVK KGMVFHLVES
860 870 880
MEEVLSLAFP KGKRVRAGTA AQSASPETLT G
Length:881
Mass (Da):97,728
Last modified:November 1, 1998 - v1
Checksum:i7D1905CD4920B504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65510.1.
PIRiB71316.
RefSeqiWP_010881972.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65510; AAC65510; TP_0524.
GeneIDi2610752.
KEGGitpa:TP_0524.
PATRICi20531087. VBITrePal57110_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65510.1.
PIRiB71316.
RefSeqiWP_010881972.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83536.
SMRiO83536. Positions 681-861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65510; AAC65510; TP_0524.
GeneIDi2610752.
KEGGitpa:TP_0524.
PATRICi20531087. VBITrePal57110_0558.

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.
OMAiVGAYKGE.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-556-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLON_TREPA
AccessioniPrimary (citable) accession number: O83536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.