Reviewed, UniProtKB/Swiss-Prot O83536 (LON_TREPA)

Names and origin

Protein names

Recommended name:
    ATP-dependent protease La
    EC=3.4.21.53

Gene names

Name:	lon
Ordered Locus Names:	TP_0524

Organism

Treponema pallidum [Complete proteome] [HAMAP]

Taxonomic identifier

160 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	881 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Degrades short-lived regulatory and abnormal proteins in presence of ATP. Hydrolyzes two ATPs for each peptide bond cleaved in the protein substrate By similarity.
Catalytic activity	Hydrolysis of proteins in presence of ATP.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S16 family. Contains 1 Lon domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 881	881	ATP-dependent protease La		PRO_0000076146
Regions
	Domain	93 – 285	193	Lon
	Nucleotide binding	440 – 447	8	ATP Potential
Sites
	Active site	767	1	By similarity
	Active site	810	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83536-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 7D1905CD4920B504	FASTA	881	97,728
	10 20 30 40 50 60 MAKNTDIEHD AHEPAGHGDV RESAVENPSA SAVSDGEERA TFAPEVAPQT DTESAQGAAQ 70 80 90 100 110 120 ESEPEVQRAG EAEKGVPEKA KAVVPLDELL PQKVHLIPLT GRPIYPGIFT PLLISDEDDV 130 140 150 160 170 180 RSVESAYSDS GFIGLCLVKT DTQNPTISDL YEVGSVARIV KKINLPDGGL NVFISTQKRF 190 200 210 220 230 240 RIRKHVHHSK PIVAAVQYLS DLIEGDPLEI KALVRGLIGE MKELSENNPL FSEEMRLNMI 250 260 270 280 290 300 NIDHPGKIAD FIASILNISK EEQQRTLEIL DVRKRMEEVF VYIKKEKDLL EIQRKIQNDL 310 320 330 340 350 360 NSRVEKNQRE YFLREELRSI KEELGLTTDP KERDQRKFRA LIDSFHFEGE VKEAVESELE 370 380 390 400 410 420 KLSLTDPNSP EYSVGRTYLE TVLSLPWHAP EKEEYDLKKA QKLLDEDHYG LENVKERIVE 430 440 450 460 470 480 YLAVRKLRAD TKGSIILLVG PPGVGKTSVG KSIARAIHKP FFRFSVGGIS DEAEIKGHRR 490 500 510 520 530 540 TYIGALPGKV LQGLKIVKTK APVFMIDEVD KIGSGARGDP AGALLEVLDP EQNTTFRDHY 550 560 570 580 590 600 LDLPFDLSHI VFVLTANSTD PIPRPLLDRA EIIRLSGYID TEKVEIAKRH LVPKTLEKNG 610 620 630 640 650 660 LKRACVSYRK EVLLHLVHSY ARESGVRGLE KSLDKLHRKL ATEIVLGKRS FDDKCLMDEA 670 680 690 700 710 720 LIGTFLGKPV FRDDMLKDAN KVGTAVGLAW TGMGGDTLLV EAITIPGKAS FKLTGQMGAV 730 740 750 760 770 780 MKESASIALS WLRRYSAQQR IASPNWFEKR AIHLHIPEGA TPKDGPSAGI TMTTTLFSLL 790 800 810 820 830 840 TQQKVKPRLA MTGELSLTGQ VLPIGGLKEK TIAARRGGIK EIIMPKANVR DLDEIPEHVK 850 860 870 880 KGMVFHLVES MEEVLSLAFP KGKRVRAGTA AQSASPETLT G

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000520 Genomic DNA. Translation: AAC65510.1.
PIR	B71316.
RefSeq	NP_218964.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2610752.
GenomeReviews	Gene locus TP_0524 in contig AE000520_GR.
KEGG	tpa:TP0524.
NMPDR	fig|243276.1.peg.523.
TIGR	TP_0524.
Phylogenomic databases
HOGENOM	O83536.
OMA	O83536. VRNYLEL.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0524-MON.
BRENDA	3.4.21.53. 142600.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR001984. Peptidase_S16_C. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view]
PRINTS	PR00830. ENDOLAPTASE.
SMART	SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view]
TIGRFAMs	TIGR00763. lon. 1 hit.
PROSITE	PS01046. LON_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LON_TREPA

Accession

Primary (citable) accession number: O83536

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)