Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O83530

- RUVC_TREPA

UniProt

O83530 - RUVC_TREPA

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231MagnesiumBy similarity
    Metal bindingi83 – 831MagnesiumBy similarity
    Metal bindingi156 – 1561MagnesiumBy similarity
    Metal bindingi159 – 1591MagnesiumBy similarity

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-549-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
    Alternative name(s):
    Holliday junction nuclease RuvC
    Holliday junction resolvase RuvC
    Gene namesi
    Name:ruvC
    Ordered Locus Names:TP_0517
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Crossover junction endodeoxyribonuclease RuvCPRO_0000183141Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiO83530. 21 interactions.
    STRINGi243276.TP0517.

    Structurei

    3D structure databases

    ProteinModelPortaliO83530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.Curated

    Phylogenomic databases

    eggNOGiCOG0817.
    KOiK01159.
    OMAiYHPDEMA.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.
    TIGRFAMsiTIGR00228. ruvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O83530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHAQNVDIAP GSTSTVSIIV GIDPGLESTG YGVIEAGGGS LRCLTYGVIV    50
    TQSNQPSAAR LRHIFDTLQQ VISIYQPQYC AVETIYFAKN VTSALCVAQA 100
    RGVVLLAMAQ QHISVAEYAP NAIKKAITGI AQAEKRQVQH LVKILLNLKD 150
    IPHPDHAADA LAVAVTHVHC CMSSNYAVGS TRSRGAYVTL YKKGKR 196
    Length:196
    Mass (Da):20,942
    Last modified:November 1, 1998 - v1
    Checksum:iBD704CF266A5C714
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65505.1.
    PIRiD71315.
    RefSeqiNP_218958.1. NC_000919.1.
    YP_008091361.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65505; AAC65505; TP_0517.
    GeneIDi15851806.
    2611279.
    KEGGitpa:TP0517.
    tpw:TPANIC_0517.
    PATRICi20531071. VBITrePal57110_0550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65505.1 .
    PIRi D71315.
    RefSeqi NP_218958.1. NC_000919.1.
    YP_008091361.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O83530. 21 interactions.
    STRINGi 243276.TP0517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65505 ; AAC65505 ; TP_0517 .
    GeneIDi 15851806.
    2611279.
    KEGGi tpa:TP0517.
    tpw:TPANIC_0517.
    PATRICi 20531071. VBITrePal57110_0550.

    Phylogenomic databases

    eggNOGi COG0817.
    KOi K01159.
    OMAi YHPDEMA.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci TPAL243276:GC1H-549-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    TIGRFAMsi TIGR00228. ruvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiRUVC_TREPA
    AccessioniPrimary (citable) accession number: O83530
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3