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O83530

- RUVC_TREPA

UniProt

O83530 - RUVC_TREPA

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene
ruvC, TP_0517
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Magnesium By similarity
Metal bindingi83 – 831Magnesium By similarity
Metal bindingi156 – 1561Magnesium By similarity
Metal bindingi159 – 1591Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-549-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:TP_0517
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Crossover junction endodeoxyribonuclease RuvCUniRule annotationPRO_0000183141Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiO83530. 21 interactions.
STRINGi243276.TP0517.

Structurei

3D structure databases

ProteinModelPortaliO83530.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
KOiK01159.
OMAiYHPDEMA.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.

Sequencei

Sequence statusi: Complete.

O83530-1 [UniParc]FASTAAdd to Basket

« Hide

MHAQNVDIAP GSTSTVSIIV GIDPGLESTG YGVIEAGGGS LRCLTYGVIV    50
TQSNQPSAAR LRHIFDTLQQ VISIYQPQYC AVETIYFAKN VTSALCVAQA 100
RGVVLLAMAQ QHISVAEYAP NAIKKAITGI AQAEKRQVQH LVKILLNLKD 150
IPHPDHAADA LAVAVTHVHC CMSSNYAVGS TRSRGAYVTL YKKGKR 196
Length:196
Mass (Da):20,942
Last modified:November 1, 1998 - v1
Checksum:iBD704CF266A5C714
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65505.1.
PIRiD71315.
RefSeqiNP_218958.1. NC_000919.1.
YP_008091361.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65505; AAC65505; TP_0517.
GeneIDi15851806.
2611279.
KEGGitpa:TP0517.
tpw:TPANIC_0517.
PATRICi20531071. VBITrePal57110_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65505.1 .
PIRi D71315.
RefSeqi NP_218958.1. NC_000919.1.
YP_008091361.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83530.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83530. 21 interactions.
STRINGi 243276.TP0517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65505 ; AAC65505 ; TP_0517 .
GeneIDi 15851806.
2611279.
KEGGi tpa:TP0517.
tpw:TPANIC_0517.
PATRICi 20531071. VBITrePal57110_0550.

Phylogenomic databases

eggNOGi COG0817.
KOi K01159.
OMAi YHPDEMA.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-549-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiRUVC_TREPA
AccessioniPrimary (citable) accession number: O83530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi