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Protein

ATP-dependent Clp protease proteolytic subunit 1

Gene

clpP1

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103NucleophileUniRule annotation1
Active sitei128UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 1UniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 1UniRule annotation
Gene namesi
Name:clpP1UniRule annotation
Synonyms:clpP-1
Ordered Locus Names:TP_0507
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001797041 – 203ATP-dependent Clp protease proteolytic subunit 1Add BLAST203

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

IntActiO83520. 7 interactors.
STRINGi243276.TP0507.

Structurei

3D structure databases

ProteinModelPortaliO83520.
SMRiO83520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ. Bacteria.
COG0740. LUCA.
KOiK01358.
OMAiLFLQSEN.

Family and domain databases

CDDicd07017. S14_ClpP_2. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiView protein in InterPro
IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiView protein in Pfam
PF00574. CLP_protease. 1 hit.
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

O83520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRERMHNLVP YVIEQSGGGE RSYDIFSRLL KDRIIFVDGE ITDAVADLVV
60 70 80 90 100
AQLLFLESQN PDKDISLYIN SPGGAVTAGL AVYDTMQHIC PEVQTICLGQ
110 120 130 140 150
ASSMAAVLLA GGAPGKRFAL PSSRVMIHQP WGGVQGQASD VCIQAQEILR
160 170 180 190 200
LKTLTIAYFA LHTGQSEEQV REDMERDFFL SAEQACSYGI VDTVMKRRKH

AQV
Length:203
Mass (Da):22,346
Last modified:November 1, 1998 - v1
Checksum:i52692B1AAB45ADB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65495.1.
PIRiB71314.
RefSeqiWP_010881956.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65495; AAC65495; TP_0507.
GeneIDi2611746.
KEGGitpa:TP_0507.

Similar proteinsi

Entry informationi

Entry nameiCLPP1_TREPA
AccessioniPrimary (citable) accession number: O83520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families