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Protein
Submitted name:

Hexokinase

Gene

TP_0505

Organism
Treponema pallidum (strain Nichols)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. hexokinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-534-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
HexokinaseImported (EC:2.7.1.1Imported)
Submitted name:
Hexokinase (Hxk)Imported
Gene namesi
Ordered Locus Names:TP_0505Imported
ORF Names:TPANIC_0505Imported
OrganismiTreponema pallidum (strain Nichols)Imported
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

IntActiO83518. 2 interactions.
STRINGi243276.TP0505.

Structurei

3D structure databases

ProteinModelPortaliO83518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

KOiK00844.
OMAiFIAECLS.
OrthoDBiEOG6TJ7TW.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

O83518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQHTRTRDL VSAFFGRFHF DVQGPSVRTV VDVLRADMVR GLEEEAQLPP
60 70 80 90 100
RMGSALAMIP TWVAPPRVSP CNRRVIVIDA GGTNFRSCLV RFGDSGTPHI
110 120 130 140 150
ENLEKRPMPG TTREYSRTEF FGEIADNLAR LKGAADCIGF CFSYPIRIRP
160 170 180 190 200
DGDGEVIQFA KEIKAAEVIG TCVGAGLTEA LSARNWPELR SLKMLNDATS
210 220 230 240 250
ALLAGFFAAP EGCSFSSYVG FILGTGMNSA YLEPDPIPKI PAHHTPQVVV
260 270 280 290 300
CESGKSNKVP RSVFDELFTQ TTAEPDIAHL EKMSSGTYLG PLASVVVRLA
310 320 330 340 350
AQEGLFSHAV HAALSTVSFT LVDMDRFLFA PSVSTTTLGA LLAPGTDTDR
360 370 380 390 400
EILFLLLDAV VARAARIAAG VIAASVLKSG AGYDPLRPVC VLAEGTTFQR
410 420 430 440
TYRLRTRVTS HLQAFLTEER GVYFDIISLE NAVTLGSALG GLSS
Length:444
Mass (Da):47,845
Last modified:October 31, 1998 - v1
Checksum:i5ACC3E1100D4B07E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65489.1.
CP004010 Genomic DNA. Translation: AGN75694.1.
PIRiE71317.
RefSeqiNP_218946.1. NC_000919.1.
YP_008091349.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65489; AAC65489; TP_0505.
AGN75694; AGN75694; TPANIC_0505.
KEGGitpa:TP0505.
tpw:TPANIC_0505.
PATRICi20531041. VBITrePal57110_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65489.1.
CP004010 Genomic DNA. Translation: AGN75694.1.
PIRiE71317.
RefSeqiNP_218946.1. NC_000919.1.
YP_008091349.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO83518. 2 interactions.
STRINGi243276.TP0505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65489; AAC65489; TP_0505.
AGN75694; AGN75694; TPANIC_0505.
KEGGitpa:TP0505.
tpw:TPANIC_0505.
PATRICi20531041. VBITrePal57110_0538.

Phylogenomic databases

KOiK00844.
OMAiFIAECLS.
OrthoDBiEOG6TJ7TW.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-534-MONOMER.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NicholsImported.
  2. "Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: Correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters."
    Petrosova H., Pospisilova P., Strouhal M., Cejkova D., Zobanikova M., Mikalova L., Sodergren E., Weinstock G.M., Smajs D.
    PLoS ONE 8:E74319-E74319(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NicholsImported.

Entry informationi

Entry nameiO83518_TREPA
AccessioniPrimary (citable) accession number: O83518
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 1998
Last sequence update: October 31, 1998
Last modified: March 31, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.