ID   O83498_TREPA            Unreviewed;       614 AA.
AC   O83498;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 124.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:AAC65466.1};
GN   OrderedLocusNames=TP_0485 {ECO:0000313|EMBL:AAC65466.1};
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65466.1, ECO:0000313|Proteomes:UP000000811};
RN   [1] {ECO:0000313|EMBL:AAC65466.1, ECO:0000313|Proteomes:UP000000811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols {ECO:0000313|EMBL:AAC65466.1,
RC   ECO:0000313|Proteomes:UP000000811};
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA   Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA   Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA   Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA   Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA   Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; AE000520; AAC65466.1; -; Genomic_DNA.
DR   PIR; C71320; C71320.
DR   RefSeq; WP_010881934.1; NC_021490.2.
DR   AlphaFoldDB; O83498; -.
DR   IntAct; O83498; 7.
DR   STRING; 243276.TP_0485; -.
DR   EnsemblBacteria; AAC65466; AAC65466; TP_0485.
DR   GeneID; 57879005; -.
DR   KEGG; tpa:TP_0485; -.
DR   PATRIC; fig|243276.9.peg.482; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_016487_0_0_12; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        281..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          309..361
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          393..528
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   614 AA;  67030 MW;  DB30561FE1071BC5 CRC64;
     MSRKNANQKI VWPLTTKLIG IISTVVVLAT IAVTAMASWF FASSLHSNAE LNNLAAAENF
     AAQIKGEFEA IATSAKSFVS LGLRSGARMH SRSALSKDFF SFYPRIGYIG VGGVAELWNG
     DFFKKNQLRV ADARRFLADN AQVISTLQTA PATLNAAPWF KAQIIAIVAP FEVDGATRNV
     VVIFSADVVQ HLLESGASSG TMYAVTWAGN SLYHPEYSLN YSNINLQDSP VVRDLRESTQ
     LTKQISFIGT DNKRYFGAFA KQTFGKFAIV LETPMSVVYQ AVYYAIILDG ILTGMVLLAS
     ILLVWFIAQS ITRPILTLVG ATHAISSGQF LLDIKPSSKD EIGLLTETFV SMGRGLAERE
     RMKEAFGKFV NRDIAEKAMK GELALGGERK TATIFFSDVR SFTEMSEKLP PEDVVEFLNE
     YMSCMVDCIE QTGGVVDKFI GDAIMAIWGA PVSLGSARLD ALQSMKAVFL MRESLIQLNE
     KRVACSKPRI GIGCGVNTGS CVAGQIGSSK RMEYTVIGDA VNTASRIEAL NKPFGTDFLI
     SENTYELVKD MLIVEKMPPI TVKGKREPLN VYAAINLKGH DGPQTLDELR ALLSIEKPGL
     SADPDFEEKK CEVI
//