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Protein
Submitted name:

Adenylate cyclase

Gene

TP_0485

Organism
Treponema pallidum (strain Nichols)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-512-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclaseImported
Submitted name:
Putative adenylate cyclaseImported (EC:4.6.1.1Imported)
Gene namesi
Ordered Locus Names:TP_0485Imported
ORF Names:TPANIC_0485Imported
OrganismiTreponema pallidum (strain Nichols)Imported
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811 Componenti: Chromosome UP000014259 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0485.

Family & Domainsi

Phylogenomic databases

KOiK01768.
OMAiRIGCGIN.
OrthoDBiEOG6VQPPK.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR003660. HAMP_linker_domain.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
SM00304. HAMP. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKNANQKI VWPLTTKLIG IISTVVVLAT IAVTAMASWF FASSLHSNAE
60 70 80 90 100
LNNLAAAENF AAQIKGEFEA IATSAKSFVS LGLRSGARMH SRSALSKDFF
110 120 130 140 150
SFYPRIGYIG VGGVAELWNG DFFKKNQLRV ADARRFLADN AQVISTLQTA
160 170 180 190 200
PATLNAAPWF KAQIIAIVAP FEVDGATRNV VVIFSADVVQ HLLESGASSG
210 220 230 240 250
TMYAVTWAGN SLYHPEYSLN YSNINLQDSP VVRDLRESTQ LTKQISFIGT
260 270 280 290 300
DNKRYFGAFA KQTFGKFAIV LETPMSVVYQ AVYYAIILDG ILTGMVLLAS
310 320 330 340 350
ILLVWFIAQS ITRPILTLVG ATHAISSGQF LLDIKPSSKD EIGLLTETFV
360 370 380 390 400
SMGRGLAERE RMKEAFGKFV NRDIAEKAMK GELALGGERK TATIFFSDVR
410 420 430 440 450
SFTEMSEKLP PEDVVEFLNE YMSCMVDCIE QTGGVVDKFI GDAIMAIWGA
460 470 480 490 500
PVSLGSARLD ALQSMKAVFL MRESLIQLNE KRVACSKPRI GIGCGVNTGS
510 520 530 540 550
CVAGQIGSSK RMEYTVIGDA VNTASRIEAL NKPFGTDFLI SENTYELVKD
560 570 580 590 600
MLIVEKMPPI TVKGKREPLN VYAAINLKGH DGPQTLDELR ALLSIEKPGL
610
SADPDFEEKK CEVI
Length:614
Mass (Da):67,030
Last modified:November 1, 1998 - v1
Checksum:iDB30561FE1071BC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65466.1.
CP004010 Genomic DNA. Translation: AGN75676.1.
PIRiC71320.
RefSeqiWP_010881934.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65466; AAC65466; TP_0485.
AGN75676; AGN75676; TPANIC_0485.
GeneIDi2611345.
KEGGitpa:TP0485.
tpw:TPANIC_0485.
PATRICi20530995. VBITrePal57110_0517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65466.1.
CP004010 Genomic DNA. Translation: AGN75676.1.
PIRiC71320.
RefSeqiWP_010881934.1. NC_021490.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65466; AAC65466; TP_0485.
AGN75676; AGN75676; TPANIC_0485.
GeneIDi2611345.
KEGGitpa:TP0485.
tpw:TPANIC_0485.
PATRICi20530995. VBITrePal57110_0517.

Phylogenomic databases

KOiK01768.
OMAiRIGCGIN.
OrthoDBiEOG6VQPPK.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-512-MONOMER.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR003660. HAMP_linker_domain.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF00672. HAMP. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
SM00304. HAMP. 1 hit.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NicholsImported.
  2. "Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters."
    Petrosova H., Pospisilova P., Strouhal M., Cejkova D., Zobanikova M., Mikalova L., Sodergren E., Weinstock G.M., Smajs D.
    PLoS ONE 8:E74319-E74319(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NicholsImported.

Entry informationi

Entry nameiO83498_TREPA
AccessioniPrimary (citable) accession number: O83498
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.