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O83491

- G6PD_TREPA

UniProt

O83491 - G6PD_TREPA

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADPUniRule annotation
Binding sitei160 – 1601NADPUniRule annotation
Binding sitei190 – 1901SubstrateUniRule annotation
Binding sitei194 – 1941SubstrateUniRule annotation
Binding sitei228 – 2281SubstrateUniRule annotation
Binding sitei247 – 2471SubstrateUniRule annotation
Active sitei252 – 2521Proton acceptorUniRule annotation
Binding sitei352 – 3521SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-505-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:TP_0478
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Glucose-6-phosphate 1-dehydrogenasePRO_0000068137Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiO83491. 1 interaction.
STRINGi243276.TP0478.

Structurei

3D structure databases

ProteinModelPortaliO83491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiVVVMYVA.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83491-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKISGSGTV APHILVIFGA SGDLAARKLI PSLWDLFEQE LLPRTFGILG
60 70 80 90 100
AGRTALSTES FRARLAEAVT KHAVRTPHDP ARLTEFLQKI HYFSFDPTDS
110 120 130 140 150
VAFADFATYV RTLDQSLHTE GNFIFYLATP PSLYETIPTQ LAMHHLNREQ
160 170 180 190 200
GNFRRVVIEK PFGYNLETAQ HLNASLRAHF QENQTYRIDH YLGKETVQNI
210 220 230 240 250
LVTRFANPLF EPTWNRTHID YVEITASESL GVENRGGYYD QSGALRDMIQ
260 270 280 290 300
NHLLLLLGII AMEAPAVVSS SRLRDEIVKV FDCLRPMGER DVMQHTVRAQ
310 320 330 340 350
YVAGKIRGVA VPGYLEESGV DPRSCTETFA ALKCYIDNWR WMDVPFYLRT
360 370 380 390 400
GKRLPTGVTE VIVHYRTLPI ALFEHIERPC AREGNALVIR IQPDEGIQLK
410 420 430 440 450
IDLKEPGAGF KTIPVSVDFQ YSALTYSHLP SAYERLLLDC MNGDNTLYHR
460 470 480 490 500
DDAVESAWRF IDPILAAWKS NKSPLLTYPA GSWGPKAADD LIKGSAPRWH
510
HPSSTLLSDD FACRL
Length:515
Mass (Da):58,032
Last modified:November 1, 1998 - v1
Checksum:i22936A1609EBD798
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65465.1.
PIRiD71319.
RefSeqiNP_218919.1. NC_000919.1.
YP_008091325.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65465; AAC65465; TP_0478.
GeneIDi15851765.
2611128.
KEGGitpa:TP0478.
tpw:TPANIC_0478.
PATRICi20530981. VBITrePal57110_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65465.1 .
PIRi D71319.
RefSeqi NP_218919.1. NC_000919.1.
YP_008091325.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83491. 1 interaction.
STRINGi 243276.TP0478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65465 ; AAC65465 ; TP_0478 .
GeneIDi 15851765.
2611128.
KEGGi tpa:TP0478.
tpw:TPANIC_0478.
PATRICi 20530981. VBITrePal57110_0510.

Phylogenomic databases

eggNOGi COG0364.
KOi K00036.
OMAi VVVMYVA.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci TPAL243276:GC1H-505-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiG6PD_TREPA
AccessioniPrimary (citable) accession number: O83491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3