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O83491 (G6PD_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:TP_0478
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068137

Sites

Active site2521Proton acceptor By similarity
Binding site531NADP By similarity
Binding site1601NADP By similarity
Binding site1901Substrate By similarity
Binding site1941Substrate By similarity
Binding site2281Substrate By similarity
Binding site2471Substrate By similarity
Binding site3521Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O83491 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 22936A1609EBD798

FASTA51558,032
        10         20         30         40         50         60 
MGKISGSGTV APHILVIFGA SGDLAARKLI PSLWDLFEQE LLPRTFGILG AGRTALSTES 

        70         80         90        100        110        120 
FRARLAEAVT KHAVRTPHDP ARLTEFLQKI HYFSFDPTDS VAFADFATYV RTLDQSLHTE 

       130        140        150        160        170        180 
GNFIFYLATP PSLYETIPTQ LAMHHLNREQ GNFRRVVIEK PFGYNLETAQ HLNASLRAHF 

       190        200        210        220        230        240 
QENQTYRIDH YLGKETVQNI LVTRFANPLF EPTWNRTHID YVEITASESL GVENRGGYYD 

       250        260        270        280        290        300 
QSGALRDMIQ NHLLLLLGII AMEAPAVVSS SRLRDEIVKV FDCLRPMGER DVMQHTVRAQ 

       310        320        330        340        350        360 
YVAGKIRGVA VPGYLEESGV DPRSCTETFA ALKCYIDNWR WMDVPFYLRT GKRLPTGVTE 

       370        380        390        400        410        420 
VIVHYRTLPI ALFEHIERPC AREGNALVIR IQPDEGIQLK IDLKEPGAGF KTIPVSVDFQ 

       430        440        450        460        470        480 
YSALTYSHLP SAYERLLLDC MNGDNTLYHR DDAVESAWRF IDPILAAWKS NKSPLLTYPA 

       490        500        510 
GSWGPKAADD LIKGSAPRWH HPSSTLLSDD FACRL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65465.1.
PIRD71319.
RefSeqNP_218919.1. NC_000919.1.
YP_008091325.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83491. 1 interaction.
STRING243276.TP0478.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65465; AAC65465; TP_0478.
GeneID15851765.
2611128.
KEGGtpa:TP0478.
tpw:TPANIC_0478.
PATRIC20530981. VBITrePal57110_0510.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
KOK00036.
OMAVVVMYVA.
OrthoDBEOG61308Z.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-505-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_TREPA
AccessionPrimary (citable) accession number: O83491
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways