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O83491

- G6PD_TREPA

UniProt

O83491 - G6PD_TREPA

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531NADPUniRule annotation
    Binding sitei160 – 1601NADPUniRule annotation
    Binding sitei190 – 1901SubstrateUniRule annotation
    Binding sitei194 – 1941SubstrateUniRule annotation
    Binding sitei228 – 2281SubstrateUniRule annotation
    Binding sitei247 – 2471SubstrateUniRule annotation
    Active sitei252 – 2521Proton acceptorUniRule annotation
    Binding sitei352 – 3521SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-505-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:TP_0478
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Glucose-6-phosphate 1-dehydrogenasePRO_0000068137Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiO83491. 1 interaction.
    STRINGi243276.TP0478.

    Structurei

    3D structure databases

    ProteinModelPortaliO83491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiVVVMYVA.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83491-1 [UniParc]FASTAAdd to Basket

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    MGKISGSGTV APHILVIFGA SGDLAARKLI PSLWDLFEQE LLPRTFGILG    50
    AGRTALSTES FRARLAEAVT KHAVRTPHDP ARLTEFLQKI HYFSFDPTDS 100
    VAFADFATYV RTLDQSLHTE GNFIFYLATP PSLYETIPTQ LAMHHLNREQ 150
    GNFRRVVIEK PFGYNLETAQ HLNASLRAHF QENQTYRIDH YLGKETVQNI 200
    LVTRFANPLF EPTWNRTHID YVEITASESL GVENRGGYYD QSGALRDMIQ 250
    NHLLLLLGII AMEAPAVVSS SRLRDEIVKV FDCLRPMGER DVMQHTVRAQ 300
    YVAGKIRGVA VPGYLEESGV DPRSCTETFA ALKCYIDNWR WMDVPFYLRT 350
    GKRLPTGVTE VIVHYRTLPI ALFEHIERPC AREGNALVIR IQPDEGIQLK 400
    IDLKEPGAGF KTIPVSVDFQ YSALTYSHLP SAYERLLLDC MNGDNTLYHR 450
    DDAVESAWRF IDPILAAWKS NKSPLLTYPA GSWGPKAADD LIKGSAPRWH 500
    HPSSTLLSDD FACRL 515
    Length:515
    Mass (Da):58,032
    Last modified:November 1, 1998 - v1
    Checksum:i22936A1609EBD798
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65465.1.
    PIRiD71319.
    RefSeqiNP_218919.1. NC_000919.1.
    YP_008091325.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65465; AAC65465; TP_0478.
    GeneIDi15851765.
    2611128.
    KEGGitpa:TP0478.
    tpw:TPANIC_0478.
    PATRICi20530981. VBITrePal57110_0510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65465.1 .
    PIRi D71319.
    RefSeqi NP_218919.1. NC_000919.1.
    YP_008091325.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O83491. 1 interaction.
    STRINGi 243276.TP0478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65465 ; AAC65465 ; TP_0478 .
    GeneIDi 15851765.
    2611128.
    KEGGi tpa:TP0478.
    tpw:TPANIC_0478.
    PATRICi 20530981. VBITrePal57110_0510.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi VVVMYVA.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci TPAL243276:GC1H-505-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiG6PD_TREPA
    AccessioniPrimary (citable) accession number: O83491
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3