Reviewed, UniProtKB/Swiss-Prot O83491 (G6PD_TREPA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	TP_0478

Organism

Treponema pallidum [Complete proteome] [HAMAP]

Taxonomic identifier

160 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068137
Sites
	Active site	252	1	Proton acceptor By similarity
	Binding site	21	1	NADP By similarity
	Binding site	53	1	NADP By similarity
	Binding site	190	1	Substrate By similarity
	Binding site	194	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83491-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 22936A1609EBD798	FASTA	515	58,032
	10 20 30 40 50 60 MGKISGSGTV APHILVIFGA SGDLAARKLI PSLWDLFEQE LLPRTFGILG AGRTALSTES 70 80 90 100 110 120 FRARLAEAVT KHAVRTPHDP ARLTEFLQKI HYFSFDPTDS VAFADFATYV RTLDQSLHTE 130 140 150 160 170 180 GNFIFYLATP PSLYETIPTQ LAMHHLNREQ GNFRRVVIEK PFGYNLETAQ HLNASLRAHF 190 200 210 220 230 240 QENQTYRIDH YLGKETVQNI LVTRFANPLF EPTWNRTHID YVEITASESL GVENRGGYYD 250 260 270 280 290 300 QSGALRDMIQ NHLLLLLGII AMEAPAVVSS SRLRDEIVKV FDCLRPMGER DVMQHTVRAQ 310 320 330 340 350 360 YVAGKIRGVA VPGYLEESGV DPRSCTETFA ALKCYIDNWR WMDVPFYLRT GKRLPTGVTE 370 380 390 400 410 420 VIVHYRTLPI ALFEHIERPC AREGNALVIR IQPDEGIQLK IDLKEPGAGF KTIPVSVDFQ 430 440 450 460 470 480 YSALTYSHLP SAYERLLLDC MNGDNTLYHR DDAVESAWRF IDPILAAWKS NKSPLLTYPA 490 500 510 GSWGPKAADD LIKGSAPRWH HPSSTLLSDD FACRL

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000520 Genomic DNA. Translation: AAC65465.1.
PIR	D71319.
RefSeq	NP_218919.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Protein-protein interaction databases
IntAct	O83491.
Genome annotation databases
GeneID	2611128.
GenomeReviews	Gene locus TP_0478 in contig AE000520_GR.
KEGG	tpa:TP0478.
NMPDR	fig|243276.1.peg.478.
TIGR	TP_0478.
Phylogenomic databases
HOGENOM	O83491.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0478-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_TREPA

Accession

Primary (citable) accession number: O83491

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1998
Last modified:	November 25, 2008
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)