Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-504-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:TP_0477
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412416-phosphogluconolactonasePRO_0000090109Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0477.

Structurei

3D structure databases

ProteinModelPortaliO83490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
KOiK01057.
OMAiDACAADY.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

O83490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHIFEDAR AIAAFLVSVF DSRLKTQEIL WLALSGGSTP REIFRTWAHE
60 70 80 90 100
FRHHLDWKRL RFFWSDERCV PPTDAQSNFN MTHSALLEPL EINPDAVFRV
110 120 130 140 150
RGEDAPESAC AAYSQEIEAR LPRQRGVPCF DIILLGMGAD GHTASIFPHE
160 170 180 190 200
IELWDHSGCC VVATHPDTGQ KRVSFTGHLI NNAHEIYVVV TGREKQDMLA
210 220 230 240
SVASDPHASV PLHAWTLPKR SGCWIPLLRG LYPRKQCKPT V
Length:241
Mass (Da):27,272
Last modified:November 1, 1998 - v1
Checksum:i148FBDA12324FEF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65464.1.
PIRiC71319.
RefSeqiNP_218918.1. NC_000919.1.
WP_010881926.1. NC_000919.1.

Genome annotation databases

EnsemblBacteriaiAAC65464; AAC65464; TP_0477.
GeneIDi2611121.
KEGGitpa:TP0477.
PATRICi20530979. VBITrePal57110_0509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65464.1.
PIRiC71319.
RefSeqiNP_218918.1. NC_000919.1.
WP_010881926.1. NC_000919.1.

3D structure databases

ProteinModelPortaliO83490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65464; AAC65464; TP_0477.
GeneIDi2611121.
KEGGitpa:TP0477.
PATRICi20530979. VBITrePal57110_0509.

Phylogenomic databases

eggNOGiCOG0363.
KOiK01057.
OMAiDACAADY.
OrthoDBiEOG63FW46.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciTPAL243276:GC1H-504-MONOMER.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry namei6PGL_TREPA
AccessioniPrimary (citable) accession number: O83490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 29, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.