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Protein

Acetate kinase

Gene

ackA

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA), Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei148Proton donor/acceptorUniRule annotation1
Sitei180Transition state stabilizerUniRule annotation1
Sitei241Transition state stabilizerUniRule annotation1
Metal bindingi388MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 212ATPUniRule annotation5
Nucleotide bindingi283 – 285ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Synonyms:ack
Ordered Locus Names:TP_0476
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001076341 – 448Acetate kinaseAdd BLAST448

Proteomic databases

PRIDEiO83489

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0476

Structurei

3D structure databases

ProteinModelPortaliO83489
SMRiO83489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
KOiK00925
OMAiWKALTGT

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O83489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILTLNCGS SSVKYQVYNW TERAVIAVGV VERVTQAGSV ITHEVHGREN
60 70 80 90 100
HVRESPCPTH TEAVQLIIST LTDAHVGVIS DMSLIKAVGH RVLHAADRFV
110 120 130 140 150
KSVVVTPDVL ETFRSVQDLG PLHNPANIRG IEAAQAVIPS VPHCAIMDTA
160 170 180 190 200
WHQTMPEASF MYAVPRQWYE EYAVRRYGFH GTSFLYTAKR ASVILKKRAE
210 220 230 240 250
DTNIIIAHIG NGASMCCVKN GVSFDTSMGI TPLEGLIMGT RCGDCDPALA
260 270 280 290 300
FYIMRKTGMS VSDIDTTLNK QSGLLGITGK YVDRRDVCAA MKNGDALARL
310 320 330 340 350
AFDMEVHRIR KYFGAYVAAL GKQPDALVFT AGVGEMCCDV RAAACAGLEH
360 370 380 390 400
LGIRLDARKN ELARTRNAET EISTDDSPVR ILVIPTDEEL VMTEDTYALM
410 420 430 440
QGTYDVHTRF TYSFQDPTYV NKARAAGLKR DLEKNPALAT IVVPRLDT
Length:448
Mass (Da):49,195
Last modified:November 1, 1998 - v1
Checksum:i7F4891EFE16F7500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA Translation: AAC65463.1
PIRiB71319
RefSeqiWP_010881925.1, NC_021490.2

Genome annotation databases

EnsemblBacteriaiAAC65463; AAC65463; TP_0476
GeneIDi34332388
KEGGitpa:TP_0476

Similar proteinsi

Entry informationi

Entry nameiACKA_TREPA
AccessioniPrimary (citable) accession number: O83489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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